| DEBATE-BIOMNI-0aafda | Are AD polygenic risk scores ready for clinical use in risk stratification, or d | 0.70 | 2 | 4 | completed | 2026-04-16 | SDA-BIOMNI-POLYGENI-b3028c7a |
| DEBATE-BIOMNI-b0e2d2 | Is a 3-marker prognostic index clinically actionable for MCI patients, or does t | 0.70 | 2 | 4 | completed | 2026-04-16 | SDA-BIOMNI-SURVIVAL-3e217f4d |
| DEBATE-BIOMNI-18feeb | Is the amyloid concentration in AD clinical trials rational given lecanemab's ap | 0.70 | 2 | 4 | completed | 2026-04-16 | SDA-BIOMNI-CLINICAL-b7a71edd |
| DEBATE-BIOMNI-f2a534 | Is a 12-protein CSF panel superior to existing plasma p-tau217 for clinical AD p | 0.70 | 2 | 4 | completed | 2026-04-16 | SDA-BIOMNI-PROTEOMI-c4a33049 |
| DEBATE-BIOMNI-33e7c0 | Is Cas13-based 4R-tau silencing feasible given collateral cleavage risks in post | 0.70 | 2 | 4 | completed | 2026-04-16 | SDA-BIOMNI-CAS13_PR-d6f415f0 |
| DEBATE-BIOMNI-8a559d | Can computationally designed binders against alpha-synuclein realistically trans | 0.70 | 2 | 4 | completed | 2026-04-16 | SDA-BIOMNI-BINDER_D-0657a9ed |
| DEBATE-BIOMNI-cedbd5 | Should clinical practice adopt multi-modal biomarker panels now, or wait for sin | 0.70 | 2 | 4 | completed | 2026-04-16 | SDA-BIOMNI-BIOMARKE-34ec007c |
| DEBATE-BIOMNI-baf74a | Is the APOE-TREM2 communication axis a therapeutic target, or is disrupting it r | 0.70 | 2 | 4 | completed | 2026-04-16 | SDA-BIOMNI-CELL_CEL-a7eed9c5 |
| DEBATE-BIOMNI-5b49bd | Is TYROBP a genuine therapeutic target in AD, or is it a downstream marker of mi | 0.70 | 2 | 4 | completed | 2026-04-16 | SDA-BIOMNI-GENE_COE-55fc5237 |
| DEBATE-BIOMNI-aff2a8 | Do spatial transcriptomic neighborhoods provide sufficient discriminative power | 0.70 | 2 | 4 | completed | 2026-04-16 | SDA-BIOMNI-SPATIAL_-c2b61633 |
| sess_SDA-2026-04-16- | test | 0.65 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-16-gap-20260416-133111 |
| sess_SDA-2026-04-16- | The abstract explicitly questions whether AD's hallmark pathologies induce choli | 0.95 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-16-gap-pubmed-20260411-082446-2c1c9e2d |
| sess_SDA-2026-04-16- | The abstract reports that Alectinib binds C1q with high affinity, but this is me | 0.94 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-16-gap-pubmed-20260410-095709-4e97c09e |
| sess_SDA-2026-04-04- | Investigate the therapeutic potential of clearing senescent cells (senolytics) t | 0.75 | 3 | 4 | completed | 2026-04-16 | SDA-2026-04-04-gap-senescent-clearance-neuro |
| sess_SDA-2026-04-16- | The skeptic raised evidence that APOE4 carriers show enhanced cholesterol synthe | 0.71 | 3 | 4 | completed | 2026-04-16 | SDA-2026-04-16-gap-debate-20260410-113104-a13caf2e |
| sess_SDA-2026-04-16- | While the study establishes LRRK2 as a lysosomal swelling sensor and notes that | 0.85 | 3 | 4 | completed | 2026-04-16 | SDA-2026-04-16-gap-pubmed-20260410-170027-a1e5f867 |
| sess_SDA-2026-04-16- | While the study demonstrates dose-response relationships between amyloid levels | 0.76 | 3 | 4 | completed | 2026-04-16 | SDA-2026-04-16-gap-pubmed-20260410-192526-f2bbb9ab |
| sess_SDA-2026-04-16- | How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle | 0.84 | 3 | 4 | completed | 2026-04-16 | SDA-2026-04-16-gap-20260416-121711 |
| sess_SDA-2026-04-16- | The debate framework identified synaptic vesicle protein modifications as critic | 0.73 | 3 | 4 | completed | 2026-04-16 | SDA-2026-04-16-gap-debate-20260411-065018-92a34465 |
| sess_SDA-2026-04-16- | The abstract suggests that Aβ-tau synergy could explain negative results from an | 0.65 | 3 | 4 | completed | 2026-04-16 | SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974 |
| sess_SDA-2026-04-12- | The debate revealed conflicting evidence about C1q's role - some studies show it | 0.58 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-12-gap-debate-20260410-112848-7ba6c2e1 |
| sess_SDA-2026-04-12- | The debate revealed that stress granules can be both neuroprotective and patholo | 0.86 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-12-gap-debate-20260410-112915-df7f8ad0 |
| sess_SDA-2026-04-12- | The debate revealed that DNAJB6 evidence is limited to polyglutamine aggregation | 0.79 | 3 | 4 | completed | 2026-04-16 | SDA-2026-04-12-gap-debate-20260410-112945-6a9ce0a3 |
| sess_SDA-2026-04-12- | The debate revealed conflicting evidence about whether HCN1 downregulation drive | 0.93 | 6 | 4 | completed | 2026-04-16 | SDA-2026-04-12-gap-debate-20260410-112951-80857f4e |
| sess_SDA-2026-04-12- | The debate highlighted major uncertainty about whether rodent glymphatic finding | 0.95 | 6 | 4 | completed | 2026-04-16 | SDA-2026-04-12-gap-debate-20260410-113010-76c2ddfd |
| sess_SDA-2026-04-16- | The debate revealed conflicting evidence about whether TRPML1 activation rescues | 0.46 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-16-gap-debate-20260410-113045-27c7b314 |
| sess_SDA-2026-04-13- | The debate framework identified functional hyperconnectivity as potentially repr | 0.95 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-13-gap-debate-20260411-065001-076e4fa7 |
| sess_SDA-2026-04-13- | The P2X7 hypothesis relies on TRIM46-mediated actin polymerization in astrocytes | 0.95 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-13-gap-debate-20260412-094638-cd9ef05d |
| sess_SDA-2026-04-13- | The abstract shows that IDH mutations reduce protein enzymatic activity yet para | 0.95 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-13-gap-pubmed-20260410-105951-ce87670d |
| sess_SDA-2026-04-13- | The study demonstrates that high-neural glioblastoma cells form synapses with ne | 0.62 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-13-gap-pubmed-20260410-171918-9936a995 |
| sess_SDA-2026-04-13- | PGC-1α is known to enhance mitochondrial function and antioxidant responses, yet | 0.70 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-13-gap-pubmed-20260410-171850-e91bcc0d |
| sess_SDA-2026-04-13- | The study shows PSEN2 is essential in cortical and dopaminergic neurons and regu | 0.68 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-13-gap-pubmed-20260410-173032-9318ca0d |
| sess_SDA-2026-04-13- | The study identifies KCNJ2 as a therapeutic target through CRISPR screening but | 0.71 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-13-gap-pubmed-20260410-173045-28238f1f |
| sess_SDA-2026-04-13- | The finding that Mertk/Axl deficiency increases viral susceptibility contradicts | 0.74 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-13-gap-pubmed-20260410-174607-708e8d91 |
| sess_SDA-2026-04-14- | The study shows that OB microglia phagocytose LC axons before amyloid plaque for | 0.70 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-14-gap-pubmed-20260410-181258-df5eee45 |
| sess_SDA-2026-04-14- | The study demonstrates significant reduction in dementia risk (HR 0.63) with GLP | 0.95 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-14-gap-pubmed-20260410-191132-d67a1191 |
| sess_SDA-2026-04-14- | The abstract reports that pericyte senescence contributes to glioma growth and i | 0.95 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-14-gap-pubmed-20260410-193006-09757220 |
| sess_SDA-2026-04-14- | Both compounds similarly reduced aging hallmarks (AMPK, Nrf2, COX IV1) and infla | 0.68 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-14-gap-pubmed-20260411-065157-53c2c658 |
| sess_SDA-2026-04-15- | The abstract shows that Gal3 binding to pTau greatly enhances tau fibrillation, | 0.92 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-15-gap-pubmed-20260411-080155-ea072afc |
| sess_SDA-2026-04-14- | The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synap | 0.95 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-14-gap-pubmed-20260411-075338-35f913fb |
| sess_SDA-2026-04-15- | The abstract shows that damaged mitochondrial inner membranes appear early in PL | 0.95 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-15-gap-pubmed-20260411-082435-2ccbb742 |
| sess_SDA-2026-04-15- | While ACSL4-driven ferroptosis was strongly supported, the molecular triggers th | 0.80 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-15-gap-debate-20260410-112528-782f5aa2 |
| sess_SDA-2026-04-15- | The debate assumed static 5-hydroxymethylcytosine patterns in aging neurons are | 0.95 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-15-gap-debate-20260410-112539-31f47880 |
| sess_SDA-2026-04-15- | All participants identified brain delivery as a critical barrier, but no mechani | 0.50 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-15-gap-debate-20260410-112545-377c1d9e |
| sess_SDA-2026-04-15- | test debate
[TARGET_ARTIFACT type=experiment id=exp-123] | 0.95 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-15-gap-20260415-221737 |
| sess_SDA-2026-04-15- | Does APOE4 drive tau propagation
[TARGET_ARTIFACT type=hypothesis id=TEST-123] | 0.64 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-15-gap-20260415-222947 |
| sess_SDA-2026-04-16- | Blood-brain barrier tight junction disruption by neuroinflammatory cytokines | 0.87 | 7 | 7 | completed | 2026-04-16 | SDA-2026-04-16-gap-bbb-tjp-20260416041707 |
| sess_SDA-2026-04-16- | Does APOE4 drive tau propagation
[TARGET_ARTIFACT type=hypothesis id=TEST-123] | 0.68 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-16-gap-20260415-222947 |
| sess_SDA-2026-04-14- | The abstract explicitly states the critical need to identify genetic risk factor | 0.58 | 0 | 4 | completed | 2026-04-16 | SDA-2026-04-14-gap-pubmed-20260410-185318-186b0446 |
| sess_SDA-2026-04-14- | The observation that salsalate and diflunisal decrease both AD and TBI incidence | 0.95 | 7 | 4 | completed | 2026-04-16 | SDA-2026-04-14-gap-pubmed-20260410-184233-98bf553f |