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Debates

915 items
IdQuestionQuality ScoreNum Hypotheses GeneratedNum RoundsStatusCreated AtAnalysis Id
sess_SDA-2026-04-06-The study establishes G3BP1's role as a tunable switch for stress granule assemb0.6974completed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041428-e14e6524
target_debate_targetShould SDC1 (Syndecan-1) be prioritized as a therapeutic target for neurodegener0.5004completed2026-04-22
target_debate_targetShould RAB27A (Ras-related protein Rab-27A) be prioritized as a therapeutic targ0.5004completed2026-04-22
sess_SDA-2026-04-06-While single-cell sequencing reveals microglial heterogeneity across regions, ag0.7374completed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041439-ec89b1e4
target_debate_targetShould MCOLN1 (Mucolipin-1) be prioritized as a therapeutic target for neurodege0.5004completed2026-04-22
sess_SDA-2026-04-06-The debate highlighted IGFBPL1's potential as a microglial master regulator but 0.6974completed2026-04-22SDA-2026-04-06-gap-debate-20260406-062045-6addd0cf
target_debate_targetShould HK2 (Hexokinase 2) be prioritized as a therapeutic target for neurodegene0.5004completed2026-04-22
sess_SDA-2026-04-06-The debate highlighted that most promising targets (VAMP2, ESCRT, fascin-1) are 0.7554completed2026-04-22SDA-2026-04-06-gap-debate-20260406-062052-7bcf4b6c
target_debate_targetShould LRP1 (LDL receptor related protein 1) be prioritized as a therapeutic tar0.5004completed2026-04-22
target_debate_targetShould AQP1 (Aquaporin-1) be prioritized as a therapeutic target for neurodegene0.5004completed2026-04-22
target_debate_targetShould TGFB1 (Transforming growth factor beta-1) be prioritized as a therapeutic0.5004completed2026-04-22
sess_SDA-2026-04-06-The debate revealed that microglial senescence markers are poorly defined compar0.7274completed2026-04-22SDA-2026-04-06-gap-debate-20260406-062101-6af4ba5f
sess_SDA-2026-04-06-The study shows SPP1 from perivascular cells drives microglial synaptic engulfme0.7074completed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-062118-e3613755
sess_SDA-2026-04-06-The debate focused on therapeutic targets but did not address how to identify pa0.7574completed2026-04-22SDA-2026-04-06-gap-debate-20260406-062039-3b945972
sess_SDA-2026-04-06-The study shows TRIM21 and autophagy receptors can eliminate both physiological 0.7574completed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041423-3a6aa4ab
sess_SDA-2026-04-06-The study shows stress granules are dynamic and reversible assemblies, but in ne0.8474completed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041428-4c4414ad
sess_SDA-2026-04-06-The abstract identifies dystrophic microglia as senescent cells in aged brains b0.7974completed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e
sess_SDA-2026-04-06-Multiple hypotheses assumed microglia could be restored to homeostatic states, b0.6374completed2026-04-22SDA-2026-04-06-gap-debate-20260406-062045-7a6cf14e
sess_SDA-2026-04-06-While DNAJB1 enhancement showed promise, the debate raised concerns about whethe0.7374completed2026-04-22SDA-2026-04-06-gap-debate-20260406-062052-28cbc764
sess_SDA-2026-04-06-The debate identified APOE4 astrocytes as potential senescence drivers but did n0.7674completed2026-04-22SDA-2026-04-06-gap-debate-20260406-062101-5d7b9dc0
sess_SDA-2026-04-06-The abstract indicates SPP1 upregulation occurs in perivascular macrophages and 0.6774completed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-062118-5e49e14f
target_debate_targetShould ANXA1 (Annexin A1) be prioritized as a therapeutic target for neurodegene0.5004completed2026-04-21
target_debate_targetShould FOXO3 (Forkhead box protein O3) be prioritized as a therapeutic target fo0.5004completed2026-04-21
target_debate_targetShould ABCA1 (ATP-binding cassette transporter A1) be prioritized as a therapeut0.5004completed2026-04-21
target_debate_targetShould ANGPT1 (Angiopoietin-1) be prioritized as a therapeutic target for neurod0.5004completed2026-04-21
target_debate_targetShould HDAC3 (Histone Deacetylase 3) be prioritized as a therapeutic target for 0.5004completed2026-04-21
target_debate_targetShould SRPK1 (SRSF protein kinase 1) be prioritized as a therapeutic target for 0.5004completed2026-04-21
target_debate_targetShould EPHB4 (Ephrin type-B receptor 4) be prioritized as a therapeutic target f0.5004completed2026-04-21
target_debate_targetShould ALOX5 (5-lipoxygenase) be prioritized as a therapeutic target for neurode0.5004completed2026-04-21
target_debate_targetShould GPX4 (Glutathione peroxidase 4) be prioritized as a therapeutic target fo0.5004completed2026-04-21
target_debate_targetShould GPR37 (G-protein coupled receptor 37) be prioritized as a therapeutic tar0.5004completed2026-04-21
target_debate_targetShould DNMT1 (DNA methyltransferase 1) be prioritized as a therapeutic target fo0.5004completed2026-04-21
target_debate_targetShould BACE1 (Beta-secretase 1) be prioritized as a therapeutic target for neuro0.5004completed2026-04-21
target_debate_targetShould STING1 (Stimulator of interferon genes protein 1) be prioritized as a the0.5004completed2026-04-21
target_debate_targetShould PPARGC1A (Peroxisome proliferator-activated receptor gamma coactivator 1-0.5004completed2026-04-21
target_debate_targetShould CASP1 (Caspase-1) be prioritized as a therapeutic target for neurodegener0.5004completed2026-04-21
target_debate_targetShould MMP2 (Matrix metalloproteinase-2) be prioritized as a therapeutic target 0.5004completed2026-04-21
target_debate_targetShould HCN1 (Hyperpolarization-activated cyclic nucleotide-gated potassium chann0.5004completed2026-04-21
target_debate_targetShould PRMT1 (Protein arginine methyltransferase 1) be prioritized as a therapeu0.5004completed2026-04-21
target_debate_targetShould SOAT1 (Sterol O-acyltransferase 1) be prioritized as a therapeutic target0.5004completed2026-04-21
target_debate_targetShould MIRO1 (Mitochondrial Rho GTPase 1) be prioritized as a therapeutic target0.5004completed2026-04-21
target_debate_targetShould TFAM (Transcription factor A, mitochondrial) be prioritized as a therapeu0.5004completed2026-04-21
target_debate_targetShould TNFA (Tumor necrosis factor alpha) be prioritized as a therapeutic target0.5004completed2026-04-21
target_debate_targetShould GJA1 (Gap junction alpha-1 protein (Connexin 43)) be prioritized as a the0.5004completed2026-04-21
target_debate_targetShould FOXO1 (Forkhead box protein O1) be prioritized as a therapeutic target fo0.5004completed2026-04-21
target_debate_targetShould TFRC (Transferrin receptor protein 1) be prioritized as a therapeutic tar0.5004completed2026-04-21
target_debate_targetShould TLR4 (Toll-like receptor 4) be prioritized as a therapeutic target for ne0.5004completed2026-04-21
target_debate_targetShould STX17 (Syntaxin-17) be prioritized as a therapeutic target for neurodegen0.5004completed2026-04-21
target_debate_targetShould TUBB3 (Tubulin beta-3 chain) be prioritized as a therapeutic target for n0.5004completed2026-04-21
target_debate_targetShould TET2 (Tet methylcytosine dioxygenase 2) be prioritized as a therapeutic t0.5004completed2026-04-21
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