| sess_SDA-2026-04-07- | The sequential therapy hypothesis depends on identifying when autophagy failure | 0.78 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062101-724971bc |
| target_debate_target | Should KCNK2 (Potassium two pore domain channel subfamily K member 2) be priorit | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | While the study establishes C1QA and C1QC as diagnostic biomarkers and confirms | 0.71 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062122-b65f8ebc |
| target_debate_target | Should PRKAA1 (AMP-activated protein kinase catalytic subunit alpha-1) be priori | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should RAB7A (Ras-related protein Rab-7a) be prioritized as a therapeutic target | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | The study shows C1qa tags synapses for microglial elimination, but doesn't expla | 0.75 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9 |
| target_debate_target | Should MTNR1A (Melatonin receptor 1A) be prioritized as a therapeutic target for | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should BCL2L1 (BCL2 Like 1) be prioritized as a therapeutic target for neurodege | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | The abstract mentions multiple organelles synchronously present structural deran | 0.80 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7 |
| target_debate_target | Should P2RX7 (P2X purinoreceptor 7) be prioritized as a therapeutic target for n | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | The study identifies cGAS/STING activation as a consequence of TDP-43-mediated m | 0.73 | 6 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-fc60e018 |
| target_debate_target | Should IDH2 (Isocitrate Dehydrogenase 2) be prioritized as a therapeutic target | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should DRD2 (Dopamine receptor D2) be prioritized as a therapeutic target for ne | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should CACNA1G (Voltage-dependent T-type calcium channel subunit alpha-1G) be pr | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should LDLR (Low density lipoprotein receptor) be prioritized as a therapeutic t | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should GABRA1 (Gamma-aminobutyric acid receptor subunit alpha-1) be prioritized | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | While the study establishes that trehalose-induced lysosomal permeabilization ac | 0.73 | 4 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062150-387cb0ba |
| sess_SDA-2026-04-07- | TDP-43 inclusions occur in AD, ALS, and FTLD but the pathogenic mechanisms leadi | 0.70 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062202-094b44bf |
| sess_SDA-2026-04-07- | The abstract mentions that pathological seeds have different characteristics and | 0.65 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062207-e4ce5cf0 |
| sess_SDA-2026-04-07- | The abstract identifies that neurons show resistance to autophagy induction, but | 0.65 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062212-ca78691c |
| sess_SDA-2026-04-08- | SQSTM1 and CALCOCO2 specifically localize to SG periphery rather than throughout | 0.69 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-041423-9c2c2ee3 |
| sess_SDA-2026-04-08- | While the study demonstrates both NF-κB pathway activation and increased C1qa ex | 0.74 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062128-afe67892 |
| sess_SDA-2026-04-08- | While the study demonstrates TDP-43 triggers mPTP-mediated mtDNA release, the mo | 0.77 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062141-739c7f1c |
| sess_SDA-2026-04-08- | The finding that trehalase-resistant analogs and other disaccharides mimic treha | 0.60 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062150-5b7d1556 |
| sess_SDA-2026-04-08- | The astrocyte-mediated hypothesis proposes memory erasure but provides no molecu | 0.65 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-debate-20260406-062033-ad87c3fb |
| sess_SDA-2026-04-08- | Both theorist and domain expert acknowledged that existing epigenetic modulators | 0.72 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-debate-20260406-062039-47e9c8cf |
| sess_SDA-2026-04-08- | AD patients with TDP-43 pathology show worse cognitive impairment, but how TDP-4 | 0.73 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062202-5c32c50a |
| sess_SDA-2026-04-08- | While ALS-causing mutations impair autophagy factors, the neuron-specific effect | 0.81 | 4 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062212-6777e5dd |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons, including D | 0.50 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| sess_SDA-2026-04-08- | The abstract mentions that antibody discovery has improved understanding of myel | 0.66 | 2 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062111-e3e328bf |
| sess_SDA-2026-04-08- | The review covers various organelle-specific autophagy types but doesn't address | 0.66 | 2 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062132-5d93ddb2 |
| sess_SDA-2026-04-10- | The clinical trialist identified this as a 'fatal clinical flaw' - no validated | 0.65 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075000-7396040a |
| sess_SDA-2026-04-10- | The ASO therapeutic hypothesis assumes dilncRNAs have targetable conserved struc | 0.69 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075007-232fbf62 |
| sess_SDA-2026-04-10- | The debate revealed fundamental uncertainty about whether HSP70/HSP90 systems ca | 0.73 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| sess_SDA-2026-04-10- | The debate identified this as the core knowledge gap but provided no mechanistic | 0.71 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075026-23501c3c |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons | 0.42 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-090500 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons
[TARGET_ART | 0.50 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091107 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons | 0.56 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091107 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons, including D | 0.48 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons, including D | 0.51 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons, including D | 0.73 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons, including D | 0.52 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091509 |
| sess_SDA-2026-04-10- | Mechanistic validation of SEA-AD differential expression hypotheses: Complement | 0.66 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-093153 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons, including D | 0.58 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091509 |
| sess_SDA-2026-04-10- | Mechanistic validation of SEA-AD differential expression hypotheses: Complement | 0.64 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-093153 |
| sess_SDA-2026-04-10- | Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in | 0.30 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-094512 |
| sess_SDA-2026-04-10- | Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-095113 |
| sess_SDA-2026-04-10- | The debate proposed α7-containing heteromers (α7β2) might be enriched in stellat | 0.30 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-095546-8e85ab15 |
| sess_SDA-2026-04-10- | The core debate question remains unresolved - whether intrinsic tau conformation | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-095556-5310dbe1 |
| sess_SDA-2026-04-10- | The debate identified that TDP-43 undergoes both normal and pathological phase s | 0.43 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-095612-b00442be |