| sess_SDA-BIOMNI-SPAT | How does spatial gene expression in the hippocampus and entorhinal cortex distin | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-SPATIAL_-c2b61633 |
| sess_SDA-BIOMNI-GENE | What co-expression modules are shared and unique across brain regions in AD, and | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-GENE_COE-55fc5237 |
| sess_SDA-BIOMNI-CELL | Which ligand-receptor interactions between glial and neuronal populations are di | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-CELL_CEL-a7eed9c5 |
| sess_SDA-BIOMNI-CAS1 | Can optimized Cas13 guide RNAs selectively silence pathogenic MAPT splice varian | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-CAS13_PR-d6f415f0 |
| sess_SDA-BIOMNI-PROT | Which proteins are differentially expressed in AD CSF and brain tissue, and do t | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-PROTEOMI-c4a33049 |
| sess_SDA-BIOMNI-BIOM | Can a multi-modal biomarker panel combining plasma proteins, neuroimaging featur | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-BIOMARKE-34ec007c |
| sess_SDA-BIOMNI-CLIN | What is the current clinical trial landscape for AD therapeutics, and which mech | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-CLINICAL-b7a71edd |
| sess_SDA-BIOMNI-BIND | Can computational de novo protein binder design produce stable binders that bloc | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-BINDER_D-0657a9ed |
| sess_SDA-BIOMNI-SURV | Which clinical, genetic, and biomarker features are independent prognostic marke | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-SURVIVAL-3e217f4d |
| sess_SDA-BIOMNI-POLY | How well do current AD polygenic risk scores predict disease onset in independen | 0.70 | 7 | 4 | completed | 2026-04-21 | SDA-BIOMNI-POLYGENI-b3028c7a |
| sess_SDA-BIOMNI-VARI | Which non-coding variants at AD GWAS loci have functional evidence for gene regu | 0.70 | 7 | 4 | completed | 2026-04-21 | SDA-BIOMNI-VARIANT_-b5b8e32f |
| sess_SDA-BIOMNI-FINE | Can Bayesian fine-mapping of the top 25 AD GWAS loci identify credible sets of c | 0.70 | 7 | 4 | completed | 2026-04-21 | SDA-BIOMNI-FINE_MAP-215bc2c6 |
| sess_SDA-BIOMNI-GENE | Which transcription factors drive the gene regulatory networks that distinguish | 0.70 | 7 | 4 | completed | 2026-04-21 | SDA-BIOMNI-GENE_REG-785b71fe |
| sess_SDA-BIOMNI-SCRN | Can standardized scRNA-seq processing and automated annotation identify novel ce | 0.70 | 7 | 4 | completed | 2026-04-21 | SDA-BIOMNI-SCRNA_AN-248caecc |
| sess_SDA-BIOMNI-MICR | How does the gut microbiome composition differ between PD patients and healthy c | 0.70 | 7 | 4 | completed | 2026-04-21 | SDA-BIOMNI-MICROBIO-337ee37a |
| sess_SDA-2026-04-21- | The fundamental premise remains unvalidated despite extensive mechanistic specul | 0.50 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-21-gap-debate-20260417-033037-c43d12c2 |
| sess_SDA-2026-04-16- | The debate revealed conflicting evidence about whether TRPML1 activation rescues | 0.72 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-16-gap-debate-20260410-113045-27c7b314 |
| sess_SDA-2026-04-10- | The abstract claims Cdk5 activation is the primary cause of AD, contradicting th | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-pubmed-20260410-185251-10f6a211 |
| sess_SDA-2026-04-11- | The debate highlighted a fundamental uncertainty about whether transgenerational | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-105844-45a775a2 |
| sess_SDA-2026-04-11- | The debate highlighted focused ultrasound as most feasible but didn't resolve cr | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-110223-e27ddf73 |
| sess_SDA-2026-04-11- | The debate assumed that correcting APOE4's aberrant domain interactions would re | 0.43 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-110241-04eef441 |
| sess_SDA-2026-04-11- | The debate highlighted that speech timing and sleep changes could reflect circad | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-110253-5fa88b6d |
| sess_SDA-2026-04-11- | Multiple participants noted the conflation of cellular dysfunction with senescen | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-110715-ae1eeb19 |
| sess_SDA-2026-04-11- | The debate highlighted that while SCFAs can cross the blood-brain barrier, the a | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-110745-72201cc8 |
| sess_SDA-2026-04-11- | The debate identified systemic toxicity as a major concern for glucosylceramide | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111106-df334a52 |
| sess_SDA-2026-04-11- | The debate highlighted that RNA granules serve essential physiological functions | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111130-9967ed0e |
| sess_SDA-2026-04-11- | The debate revealed a fundamental gap: whether disease-specific C1q conformation | 0.51 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111529-85a3197f |
| sess_SDA-2026-04-11- | The debate highlighted that mitochondrial transfer could be therapeutic, but rai | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111536-ebde9783 |
| sess_SDA-2026-04-11- | The stage-dependent strategy assumes sequential drug switching is feasible, but | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111928-22fc607c |
| sess_SDA-2026-04-11- | The debate revealed a critical gap: while PINK1/PARKIN deficiency correlates wit | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111936-47b73d88 |
| sess_SDA-2026-04-11- | All participants agreed that transcriptomic vulnerability signatures don't estab | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111936-9a9b8c46 |
| sess_SDA-2026-04-11- | The debate revealed a critical gap: while excitatory neurons show mitochondrial | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111943-688d4ed6 |
| sess_SDA-2026-04-10- | While genetic evidence links autophagy dysfunction to neurodegeneration, the deb | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-113045-6fcb3f6c |
| sess_SDA-2026-04-10- | The core causation versus correlation debate remains unresolved despite being ce | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-112348-a10cb6b4 |
| sess_SDA-2026-04-10- | All participants identified BBB penetration as a critical bottleneck, but no exi | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-112625-6c2ceffa |
| sess_SDA-2026-04-19- | Investigate shared DNA methylation age acceleration and histone modification pat | 1.00 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-19-gap-epigenetic-comparative-ad-pd-als |
| sess_SDA-2026-04-11- | The debate generated therapeutic hypotheses targeting different cell types but n | 1.00 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-112336-ccdef571 |
| sess_SDA-2026-04-11- | The debate identified that ketone levels >2.0 mM may disrupt astrocyte-neuron me | 1.00 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-112343-6340ce52 |
| sess_SDA-2026-04-11- | The debate proposed temporal TFEB modulation but identified no validated biomark | 1.00 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-112348-d9e9b948 |
| sess_SDA-2026-04-11- | The debate highlighted major safety concerns about blocking CXCL10, particularly | 1.00 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-112406-461e1f01 |
| sess_SDA-2026-04-11- | The debate raised conflicting views on whether myelin restoration would be benef | 1.00 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-112430-676f2b59 |
| sess_SDA-2026-04-11- | The debate highlighted P2RX7's dual role in both harmful exosome secretion and b | 1.00 | 7 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-112451-1ee4bcc4 |
| sess_SDA-2026-04-11- | The debate highlighted fundamental disagreement about tau's role - whether aggre | 1.00 | 7 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-112457-6c066349 |
| sess_SDA-2026-04-11- | The debate revealed conflicting therapeutic approaches - enhancing DNA repair ve | 1.00 | 7 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-112503-d3625e8c |
| sess_SDA-2026-04-18- | Investigate shared DNA methylation age acceleration and histone modification pat | 1.00 | 7 | 4 | completed | 2026-04-20 | SDA-2026-04-18-gap-epigenetic-comparative-ad-pd-als |
| sess_SDA-2026-04-16- | Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma | 0.50 | 7 | 4 | completed | 2026-04-20 | SDA-2026-04-16-gap-20260416-220243 |
| sess_SDA-2026-04-02- | What are the mechanisms by which tau pathology spreads through connected brain r | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-02-gap-tau-propagation-20260402 |
| wrap_SDA-2026-04-17- | The fundamental premise remains unvalidated despite extensive mechanistic specul | 1.00 | 7 | 4 | completed | 2026-04-19 | SDA-2026-04-17-gap-debate-20260417-033037-c43d12c2 |
| sess_SDA-2026-04-16- | How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what | 0.50 | 3 | 4 | completed | 2026-04-18 | |
| sess_SDA-2026-04-11- | The debate proposed P16INK4A-guided targeting but the Skeptic noted microglia ex | 0.50 | 0 | 4 | completed | 2026-04-18 | SDA-2026-04-11-gap-debate-20260410-112619-9c3c13d2 |