| sess_SDA-2026-04-07- | While the study establishes that trehalose-induced lysosomal permeabilization ac | 0.73 | 4 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062150-387cb0ba |
| sess_SDA-2026-04-07- | TDP-43 inclusions occur in AD, ALS, and FTLD but the pathogenic mechanisms leadi | 0.70 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062202-094b44bf |
| sess_SDA-2026-04-07- | The abstract mentions that pathological seeds have different characteristics and | 0.65 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062207-e4ce5cf0 |
| sess_SDA-2026-04-07- | The abstract identifies that neurons show resistance to autophagy induction, but | 0.65 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062212-ca78691c |
| sess_SDA-2026-04-08- | SQSTM1 and CALCOCO2 specifically localize to SG periphery rather than throughout | 0.69 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-041423-9c2c2ee3 |
| sess_SDA-2026-04-08- | While the study demonstrates both NF-κB pathway activation and increased C1qa ex | 0.74 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062128-afe67892 |
| sess_SDA-2026-04-08- | While the study demonstrates TDP-43 triggers mPTP-mediated mtDNA release, the mo | 0.77 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062141-739c7f1c |
| sess_SDA-2026-04-08- | The finding that trehalase-resistant analogs and other disaccharides mimic treha | 0.60 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062150-5b7d1556 |
| sess_SDA-2026-04-08- | The astrocyte-mediated hypothesis proposes memory erasure but provides no molecu | 0.65 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-debate-20260406-062033-ad87c3fb |
| sess_SDA-2026-04-08- | Both theorist and domain expert acknowledged that existing epigenetic modulators | 0.72 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-debate-20260406-062039-47e9c8cf |
| sess_SDA-2026-04-08- | AD patients with TDP-43 pathology show worse cognitive impairment, but how TDP-4 | 0.73 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062202-5c32c50a |
| sess_SDA-2026-04-08- | While ALS-causing mutations impair autophagy factors, the neuron-specific effect | 0.81 | 4 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062212-6777e5dd |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons, including D | 0.50 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| sess_SDA-2026-04-08- | The abstract mentions that antibody discovery has improved understanding of myel | 0.66 | 2 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062111-e3e328bf |
| sess_SDA-2026-04-08- | The review covers various organelle-specific autophagy types but doesn't address | 0.66 | 2 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062132-5d93ddb2 |
| sess_SDA-2026-04-10- | The clinical trialist identified this as a 'fatal clinical flaw' - no validated | 0.65 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075000-7396040a |
| sess_SDA-2026-04-10- | The ASO therapeutic hypothesis assumes dilncRNAs have targetable conserved struc | 0.69 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075007-232fbf62 |
| sess_SDA-2026-04-10- | The debate revealed fundamental uncertainty about whether HSP70/HSP90 systems ca | 0.73 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| sess_SDA-2026-04-10- | The debate identified this as the core knowledge gap but provided no mechanistic | 0.71 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075026-23501c3c |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons | 0.42 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-090500 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons
[TARGET_ART | 0.50 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091107 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons | 0.56 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091107 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons, including D | 0.48 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons, including D | 0.51 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons, including D | 0.73 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons, including D | 0.52 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091509 |
| sess_SDA-2026-04-10- | Mechanistic validation of SEA-AD differential expression hypotheses: Complement | 0.66 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-093153 |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons, including D | 0.58 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091509 |
| sess_SDA-2026-04-10- | Mechanistic validation of SEA-AD differential expression hypotheses: Complement | 0.64 | 0 | 0 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-093153 |
| sess_SDA-2026-04-10- | Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in | 0.30 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-094512 |
| sess_SDA-2026-04-10- | Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-095113 |
| sess_SDA-2026-04-10- | The debate proposed α7-containing heteromers (α7β2) might be enriched in stellat | 0.30 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-095546-8e85ab15 |
| sess_SDA-2026-04-10- | The core debate question remains unresolved - whether intrinsic tau conformation | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-095556-5310dbe1 |
| sess_SDA-2026-04-10- | The debate identified that TDP-43 undergoes both normal and pathological phase s | 0.43 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-095612-b00442be |
| sess_SDA-2026-04-10- | The debate highlighted a critical cell-type specificity gap where no evidence ex | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-095945-976d542d |
| sess_SDA-2026-04-10- | The debate presented conflicting evidence for convergent vs. stimulus-specific c | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-095952-12fad421 |
| sess_SDA-2026-04-10- | The debate hinged on whether HSP90 adopts unique conformations when bound to tau | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-095958-ccbb9a80 |
| sess_SDA-2026-04-10- | This fundamental question underlies all therapeutic hypotheses but lacks experim | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-100007-6c187cfd |
| sess_SDA-2026-04-10- | The core research question was never addressed due to missing literature content | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-100352-6c86d947 |
| sess_SDA-2026-04-10- | The debate was structured around this question but no literature was provided to | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-100357-76f5b31e |
| sess_SDA-2026-04-10- | The debate identified a critical gap in understanding whether PS exposure is tau | 0.44 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-100359-5f096b45 |
| sess_SDA-2026-04-10- | The debate revealed a fundamental gap in understanding whether tau pathology dir | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-100403-c213d072 |
| sess_SDA-2026-04-11- | The debate proposed biphasic TREM2 modulation but couldn't define when to switch | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-100405-abac24bc |
| sess_SDA-2026-04-11- | The debate proposed temporal TREM2 modulation but couldn't define when to switch | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-100409-e0118210 |
| sess_SDA-2026-04-11- | The debate identified this as a critical mechanistic gap - TFEB may increase lys | 0.30 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-100423-78eecb9f |
| sess_SDA-2026-04-11- | While the debate proposes ADCY8-cAMP-PKA-CREB pathways, the exact molecular step | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-105819-f7d141d0 |
| sess_SDA-2026-04-11- | The debate identified glycolytic shifts and mTOR disruption but couldn't disting | 0.48 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-105826-6e561b44 |
| sess_SDA-2026-04-11- | The debate highlighted receptor desensitization as a critical concern for SPM re | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-110721-4df69d8e |
| sess_SDA-2026-04-04- | How do metabolomic alterations in glucose metabolism, mitochondrial function, an | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-04-frontier-metabolomics-f03b09d9 |
| sess_SDA-2026-04-11- | The debate revealed fundamental uncertainty about whether enhancing TYROBP-SYK s | 0.30 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111113-052488a8 |