| h-869b5707e8 | TREM2 Microglial Agonism for Enhanced Phagocytosis | 0.59 | 0.58 | TREM2 | proposed | 2026-05-04 | SDA-2026-05-04-gap-test-20260425-224949 |
| h-338bb5c155 | Baseline Elevation from ER Stress Is Epiphenomenon, Not Lysosomal Signal Amplifi | 0.59 | 0.52 | PERK,LRRK2 | proposed | 2026-04-26 | SDA-2026-04-23-gap-debate-20260417-033119-54941818 |
| h-412e5c37d3 | Intermittent HBOT (2.0 ATA, 60 min, 3x/week) suppresses NLRP3 inflammasome and s | 0.59 | 0.60 | NLRP3 | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-181340-8acb24dc-debate |
| h-a4fca7bb87 | Peri-plaque tau seeding restraint via TREM2-competent microglia | 0.59 | 0.60 | TREM2 | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-150544-e3a2eab9-debate |
| h-78a93db210 | Direct ISR target engagement likely requires trazodone doses around 150-200 mg/d | 0.59 | 0.68 | EIF2AK3; EIF2S1; ATF4; DDIT3 | proposed | 2026-04-25 | |
| h-0a073f51c0 | A post-trigger CDK5-dominant kinase feedback loop maintains dendritic phospho-ta | 0.59 | 0.63 | MAPT,CDK5,CAPN1,GSK3B | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-98a600b3ed |
| h-663b2136a8 | APOE isoform modifies the C1q binding landscape, biasing C1q toward inflammatory | 0.59 | 0.55 | APOE,C1QA,C1QB,C1QC,TREM2,APP | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-afba1a80bd |
| h-b4b09dedb2 | G3BP1 Haploinsufficiency Reveals a Therapeutic Window for SG-Targeting Intervent | 0.59 | 0.50 | G3BP1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041428-e14e6524 |
| h-175225ed30 | Competition with G3BP1-Caprin1/FMRP Scaffold Formation | 0.59 | 0.62 | G3BP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041423-2d1db50c |
| h-8ffdaff434 | CHIP-mediated ubiquitination selectively targets oligomeric pathologic conformer | 0.59 | 0.58 | STUB1 (CHIP), HSPA8, VCP, PSMD4 | proposed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| h-47ab2be5 | Multiplexed Base Editing for Simultaneous Neuroprotective Gene Activation | 0.59 | 0.55 | SOD1, TARDBP, BDNF, GDNF, IGF-1 | proposed | 2026-04-04 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-12cb145d57 | Microglial Replacement and Ontogeny Shift | 0.59 | 0.60 | CCR2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-d4d93da2 | M1 Muscarinic Receptor Agonism as Pharmacological Exercise Substitute | 0.59 | 0.72 | CHRM1 | promoted | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-191046-15921012 |
| h-var-5aec85b987 | TREM2-Mediated Microglial Dysfunction Disrupts Oligodendrocyte Tau Clearance Net | 0.59 | 0.71 | TREM2 | proposed | 2026-04-12 | SDA-2026-04-03-26abc5e5f9f2 |
| h-cae1ad2e | Astrocyte-Derived EV miR-146a-5p Mimics as Erasers of Trained Microglial NF-κB M | 0.59 | 0.58 | miR-146a-5p → IRAK1, TRAF6, NOTCH1, HDAC1 | proposed | 2026-04-26 | SDA-2026-04-08-gap-debate-20260406-062033-ad87c3fb |
| h-4639c944 | AP1S1-Mediated Vesicular Transport Restoration | 0.59 | 0.60 | AP1S1 | proposed | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-cc1076c1 | Cardiovascular-Neuroinflammation Crosstalk Interruption | 0.59 | 0.50 | IL1B, TNFA, NLRP3 | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-var-3891c45d35 | TREM2-Mediated Oligodendrocyte-Microglia Signaling in White Matter Neurodegenera | 0.59 | 0.53 | TREM2 | proposed | 2026-04-21 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-678435d0 | TNFRSF25-Mediated Aging Exosome Pathway Inhibition | 0.59 | 0.45 | TNFRSF25 | proposed | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-9c857387 | TREM2 Signaling Bifurcation with Independent TYROBP-Independent Homeostatic Main | 0.59 | 0.40 | TREM2 | promoted | 2026-04-15 | SDA-2026-04-14-gap-pubmed-20260411-072446-a32fa49c |
| h-6e2ad5b857 | CSF p-tau217 Normalization Reflects Amyloid-Driven Tau Pathology Resolution (Mec | 0.59 | 0.55 | NA - Mechanistic hypothesis | proposed | 2026-04-25 | |
| h-894b633a | REDD1-mTOR Axis as the Master Regulator — Preservation Over Chelation | 0.59 | 0.62 | DDIT4 (REDD1), MTOR | promoted | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-092119-691e1977 |
| h-08a79bc5 | Senescence-Tau Decoupling Therapy | 0.59 | 0.40 | CDKN2A | proposed | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-bce00cb086 | Neuropeptide Y (NPY) Co-release from PV Interneurons Modulates Aβ Toxicity | 0.59 | 0.58 | NPY/NPY1R | proposed | 2026-04-28 | SRB-2026-04-28-h-var-e95d2d1d86 |
| h-9119128b99 | Closed-Loop Phase-Specific Targeting of PV-to-Pyramidal Synapses Corrects Aβ-Ind | 0.59 | 0.60 | GRIN2B/PV | proposed | 2026-04-28 | SRB-2026-04-28-h-var-e95d2d1d86 |
| h-SDA-2026-04-26-gap | Circadian-Phase Anchored Low-Dose Melatonin for Prevention | 0.59 | 0.43 | MT1/MT2 melatonin receptors; CLOCK/BMAL1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260411-090734-1be1b913 |
| h-SDA-2026-04-26-gap | Residual Vascular Amyloid Prevents Complete CSF p-tau217 Normalization, Requirin | 0.59 | 0.36 | APOE, CLU | proposed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260417-033134-20519caa |
| h-e3a48208 | Mitochondrial-Lysosomal Coupling Enhancer | 0.59 | 0.50 | LAMTOR1 | proposed | 2026-04-04 | SDA-2026-04-03-gap-debate-20260403-222617-8eb5bdbc |
| h-89be8460d0 | Mitophagy Induction as Neuroprotective Strategy in Sporadic Parkinson's Disease | 0.58 | 0.65 | USP30 | proposed | 2026-04-26 | legacy-pre-pipeline-import-v1 |
| h-29d142abaa | ALS-Associated G3BP1/2 Mutations Disrupt TRIM21 Binding Interfaces | 0.58 | 0.60 | G3BP1, G3BP2 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041423-3a6aa4ab |
| h-50d04444e4 | P2RY12-driven autophagy impairment in cerebral VSMCs mediates BBB breakdown and | 0.58 | 0.62 | P2RY12 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041434-d7920f3b |
| h-9d16afa0 | FcRn Transport Bypass Strategy | 0.58 | 0.75 | LDLR | proposed | 2026-04-12 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-var-4d43a26612 | Optogenetic restoration of hippocampal gamma oscillations via selective SST inte | 0.58 | 0.65 | SST | proposed | 2026-04-07 | SDA-2026-04-03-26abc5e5f9f2 |
| h-9025d807 | PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5)P2→TRPML1→Calcineur | 0.58 | 0.55 | PIKFYVE/MCOLN1/PPP3CB/TFEB | promoted | 2026-04-13 | SDA-2026-04-13-gap-pubmed-20260410-143119-8ae42941 |
| h-9a721223 | NOMO1-Mediated Neuronal Resilience Enhancement | 0.58 | 0.45 | NOMO1 | proposed | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-85173a30c8 | APOE4 Creates Accelerated, Compressed Reversibility Window | 0.58 | 0.52 | APOE/TREM2 axis, APOE-TREM2 physical interaction | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062045-7a6cf14e |
| h-3460f820 | TREM2-Mediated Selective Aggregate Clearance Pathway | 0.58 | 0.50 | TREM2 | proposed | 2026-04-02 | SDA-2026-04-01-gap-9137255b |
| h-4e823a876a | Upstream restoration of glial lipid efflux and apoE lipidation will outperform d | 0.58 | 0.52 | LXR | proposed | 2026-04-24 | SDA-2026-04-25-gapdebate-f4c8357045 |
| h-d4ff5555 | IGFBPL1-Mediated Homeostatic Restoration | 0.58 | 0.80 | IGFBPL1 | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-analogy-8485c6fb | TREM2-mediated PV interneuron stabilization to restore gamma coherence in protei | 0.58 | 0.45 | PVALB / TREM2 | active | 2026-04-28 | |
| h-c0c52aec62 | Multivalent Scaffold Theory: Rif1 SAF Domain Array as High-Valency Condensate Co | 0.58 | 0.68 | RIF1 | proposed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075026-23501c3c |
| h-5240d15b04 | Pharmacological P2RY12 inhibition (ticagrelor/clopidogrel) as repurposing probe | 0.58 | 0.58 | P2RY12 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041434-d7920f3b |
| h-b35f2ff8 | Gamma Entrainment Synergy: HBOT-Enhanced Cerebral Perfusion Amplifies SST Intern | 0.58 | 0.52 | | proposed | 2026-04-17 | SDA-2026-04-26-gap-pubmed-20260410-181340-8acb24dc-debate |
| h-ec79168b | GPC4/HSPGs Collaborate with ApoE Isoforms to Dictate Tau Conformational Strain U | 0.58 | 0.58 | GPC4/APOE | promoted | 2026-04-16 | SDA-2026-04-15-gap-debate-20260410-112730-24052bbe |
| h-d5dc9661b1 | SCFA Deficiency Disrupts Microglial Homeostasis and Promotes Neurodegeneration | 0.58 | 0.55 | HDAC3/GPR43 (FFAR2)/IL10/TREM2/OCLN | proposed | 2026-04-26 | SDA-2026-04-26-gut-brain-pd-ffdff6f4 |
| h-55ef81c5 | Extracellular Vesicle Biogenesis Modulation | 0.58 | 0.34 | CHMP4B | archived | 2026-04-02 | SDA-2026-04-04-gap-tau-prop-20260402003221 |
| h-56af4a2b91 | Ganglioside-rich extracellular vesicles preserve alpha-synuclein fibril conforma | 0.58 | 0.54 | SNCB | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260411-081644-1d2624b8-debate |
| h-b0defed1 | ITGAM/CD11b direct binding explains microglial phagocytosis blockade | 0.58 | 0.62 | ITGAM | proposed | 2026-04-21 | SDA-2026-04-21-gap-debate-20260417-033037-c43d12c2 |
| h-3685e352 | CSF1R Inhibition-Mediated Microglial Replacement as a State Transition Reset | 0.58 | 0.70 | CSF1R | promoted | 2026-04-16 | SDA-2026-04-16-gap-debate-20260410-112642-fffdca96 |
| h-762a78d0af | RNA Metabolism and Nucleocytoplasmic Transport Defects | 0.58 | 0.62 | RanGAP1, NUP205, C9orf72, FUS | proposed | 2026-04-28 | SDA-2026-04-28-cross-disease-synthesis |