| h-SDA-2026-04-26-gap | Residual Vascular Amyloid Prevents Complete CSF p-tau217 Normalization, Requirin | 0.59 | 0.36 | APOE, CLU | proposed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260417-033134-20519caa |
| h-e3a48208 | Mitochondrial-Lysosomal Coupling Enhancer | 0.59 | 0.50 | LAMTOR1 | proposed | 2026-04-04 | SDA-2026-04-03-gap-debate-20260403-222617-8eb5bdbc |
| h-89be8460d0 | Mitophagy Induction as Neuroprotective Strategy in Sporadic Parkinson's Disease | 0.58 | 0.65 | USP30 | proposed | 2026-04-26 | legacy-pre-pipeline-import-v1 |
| h-29d142abaa | ALS-Associated G3BP1/2 Mutations Disrupt TRIM21 Binding Interfaces | 0.58 | 0.60 | G3BP1, G3BP2 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041423-3a6aa4ab |
| h-50d04444e4 | P2RY12-driven autophagy impairment in cerebral VSMCs mediates BBB breakdown and | 0.58 | 0.62 | P2RY12 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041434-d7920f3b |
| h-9d16afa0 | FcRn Transport Bypass Strategy | 0.58 | 0.75 | LDLR | proposed | 2026-04-12 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-var-4d43a26612 | Optogenetic restoration of hippocampal gamma oscillations via selective SST inte | 0.58 | 0.65 | SST | proposed | 2026-04-07 | SDA-2026-04-03-26abc5e5f9f2 |
| h-9025d807 | PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5)P2→TRPML1→Calcineur | 0.58 | 0.55 | PIKFYVE/MCOLN1/PPP3CB/TFEB | promoted | 2026-04-14 | SDA-2026-04-13-gap-pubmed-20260410-143119-8ae42941 |
| h-9a721223 | NOMO1-Mediated Neuronal Resilience Enhancement | 0.58 | 0.45 | NOMO1 | proposed | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-85173a30c8 | APOE4 Creates Accelerated, Compressed Reversibility Window | 0.58 | 0.52 | APOE/TREM2 axis, APOE-TREM2 physical interaction | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062045-7a6cf14e |
| h-3460f820 | TREM2-Mediated Selective Aggregate Clearance Pathway | 0.58 | 0.50 | TREM2 | proposed | 2026-04-03 | SDA-2026-04-01-gap-9137255b |
| h-4e823a876a | Upstream restoration of glial lipid efflux and apoE lipidation will outperform d | 0.58 | 0.52 | LXR | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-f4c8357045 |
| h-d4ff5555 | IGFBPL1-Mediated Homeostatic Restoration | 0.58 | 0.80 | IGFBPL1 | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-analogy-8485c6fb | TREM2-mediated PV interneuron stabilization to restore gamma coherence in protei | 0.58 | 0.45 | PVALB / TREM2 | active | 2026-04-28 | |
| h-c0c52aec62 | Multivalent Scaffold Theory: Rif1 SAF Domain Array as High-Valency Condensate Co | 0.58 | 0.68 | RIF1 | proposed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075026-23501c3c |
| h-5240d15b04 | Pharmacological P2RY12 inhibition (ticagrelor/clopidogrel) as repurposing probe | 0.58 | 0.58 | P2RY12 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041434-d7920f3b |
| h-b35f2ff8 | Gamma Entrainment Synergy: HBOT-Enhanced Cerebral Perfusion Amplifies SST Intern | 0.58 | 0.52 | | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-181340-8acb24dc |
| h-ec79168b | GPC4/HSPGs Collaborate with ApoE Isoforms to Dictate Tau Conformational Strain U | 0.58 | 0.58 | GPC4/APOE | promoted | 2026-04-16 | SDA-2026-04-15-gap-debate-20260410-112730-24052bbe |
| h-d5dc9661b1 | SCFA Deficiency Disrupts Microglial Homeostasis and Promotes Neurodegeneration | 0.58 | 0.55 | HDAC3/GPR43 (FFAR2)/IL10/TREM2/OCLN | proposed | 2026-04-26 | SDA-2026-04-26-gut-brain-pd-ffdff6f4 |
| h-55ef81c5 | Extracellular Vesicle Biogenesis Modulation | 0.58 | 0.34 | CHMP4B | archived | 2026-04-02 | SDA-2026-04-04-gap-tau-prop-20260402003221 |
| h-56af4a2b91 | Ganglioside-rich extracellular vesicles preserve alpha-synuclein fibril conforma | 0.58 | 0.54 | SNCB | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260411-081644-1d2624b8-debate |
| h-b0defed1 | ITGAM/CD11b direct binding explains microglial phagocytosis blockade | 0.58 | 0.62 | ITGAM | proposed | 2026-04-21 | SDA-2026-04-21-gap-debate-20260417-033037-c43d12c2 |
| h-3685e352 | CSF1R Inhibition-Mediated Microglial Replacement as a State Transition Reset | 0.58 | 0.70 | CSF1R | promoted | 2026-04-17 | SDA-2026-04-16-gap-debate-20260410-112642-fffdca96 |
| h-762a78d0af | RNA Metabolism and Nucleocytoplasmic Transport Defects | 0.58 | 0.62 | RanGAP1, NUP205, C9orf72, FUS | proposed | 2026-04-28 | SDA-2026-04-28-cross-disease-synthesis |
| h-85bc154b49 | TFEB Nuclear Translocation Clears α-Synuclein via Autophagy-Lysosome Pathway | 0.58 | 0.62 | TFEB (MLST8) | proposed | 2026-04-28 | SDA-TEST-PREREG-003 |
| h-cf3596a8f7 | Selective c-Abl Inhibition Promotes α-Synuclein Clearance via Autophagy | 0.58 | 0.68 | ABL1/c-Abl | proposed | 2026-04-26 | test-hypothesis-fixtures-v1 |
| h-1431a507bf | Gut Bacterial Metabolite-AhR Dysregulation Converts SCFA-Deficiency into IDO1-Dr | 0.58 | 0.65 | AHR, IDO1, KYNU, HAAO, GRIN2A, STAT3 | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260425-225305 |
| h-f7db2634ee | LXR Agonism (H4): Microglial Lipid Efflux Promotion | 0.58 | 0.62 | NR1H3 (LXRα/NR1H3) | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-180918-962b1ada-debate |
| h-5559a65b3f | Liproxstatin-1 as Mechanism-Validation Tool for Ferroptosis Inhibition | 0.58 | 0.65 | ALOX12/15 (12/15-lipoxygenase) / HDAC4 axis | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-174000-6451afef-debate |
| h-c42d677719 | A lower trazodone dose of 50-100 mg nightly may be sufficient only in dementia p | 0.58 | 0.45 | HTR2A; HRH1; AQP4 | proposed | 2026-04-26 | |
| h-ba57f3d3ed | LYTL and JIP4-dependent lysosomal remodeling may show mutant-selective amplifica | 0.58 | 0.61 | JIP4,LRRK2,RAB10,RAB35 | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-9180363b7c |
| h-16818f9bf1 | APOE4 Structural Correction by Small Molecule Correctors | 0.58 | 0.55 | APOE4 | proposed | 2026-04-22 | SDA-2026-04-02-gap-apoe4-targeting |
| h-d0099a1106 | Structure-interacting small molecules that stabilize the APOE4 molten globule do | 0.58 | 0.55 | APOE (protein structure stabilizer) | proposed | 2026-04-22 | SDA-2026-04-04-gap-apoe4-lipid-metabolism |
| h-a1f87d1fd6 | APOE4 drives astrocyte metabolic reprogramming toward glycolysis via PGC-1α supp | 0.58 | 0.58 | PPARGC1A (PGC-1α), SIRT1, SREBF1 (SREBP1c) | proposed | 2026-04-22 | SDA-2026-04-04-gap-apoe4-lipid-metabolism |
| h-e744d98ee1 | LAMP-2 replacement therapy prevents lysosomal membrane permeabilization and down | 0.58 | 0.55 | LAMP2 (LGMN) | proposed | 2026-04-22 | SDA-2026-04-04-gap-lysosomal-cathepsin-ad |
| h-684a2fffb5 | Dysregulated G3BP1 Signaling Impairs Local Translation in Neuronal Processes, Co | 0.58 | 0.55 | G3BP1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041428-e14e6524 |
| h-d3a2216a86 | Female Microglia Exhibit Reduced P2Y12 Expression Conferring Neuroprotection Thr | 0.58 | 0.58 | P2RY12 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-ec89b1e4 |
| h-6358a464ac | αvβ3 Integrin-FAK-SYK-CARD9/NF-κB Pathway | 0.58 | 0.68 | ITGAV/ITGB3 (αvβ3 heterodimer), PTK2 (FAK), SYK, CARD9 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-062118-e3613755 |
| h-0fcf8ff993 | H5: Complement Dysregulation Drives Synapse Loss via Senescent APOE4 Astrocytes | 0.58 | 0.55 | C3; C3AR1; C5AR1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-5d7b9dc0 |
| h-81bb99f5b9 | H7: Dual-Target Strategy (Senolytics + APOE4→3 Conversion) | 0.58 | 0.58 | APOE; CDKN2A | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-5d7b9dc0 |
| h-3cdc8defe3 | Limited Calcium Release Without Sufficient Cathepsin Efflux | 0.58 | 0.55 | TRPML1/MCOLN1, Calcineurin/NFAT | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062150-a6cc7467 |
| h-494ad6afe0 | Nuclear Export Deficits Increase Cytosolic TDP-43 Burden | 0.58 | 0.55 | XPO1/CRM1, ALYREF, THOC1/THOC2, TDP-43 NLS | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-611cf046 |
| h-c1828e7264 | Neuroinflammation-Driven TDP-43 Mislocalization via Microglial APOE4 Signaling | 0.58 | 0.52 | NLRP3, LRP1, IL1B, TNF | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062202-c8c5a9a1 |
| h-6f274df61e | Disrupted AQP4-Mediated K+ Spatial Buffering Causes Neuronal Hyperexcitability a | 0.58 | 0.58 | AQP4; KCNJ10 (Kir4.1); ATP1A2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-ce0abc1e |
| h-47e3c2965c | AQP4 Missorting in Reactive Astrocytes Drives Glymphatic Failure in Chronic Neur | 0.58 | 0.55 | AQP4; STAT3; MMP9 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-ce0abc1e |
| h-9f504f5d4d | Astrocyte cGAS/STING Activation Converts Protective into Destructive Neuroinflam | 0.58 | 0.55 | STING (TMEM173) in astrocytes (GFAP+ cells) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-fc60e018 |
| h-b6af8aa071 | Microglial Priming via NF-κB-Dependent DAM Phenotype and Complement Biosynthesis | 0.58 | 0.55 | NFKB1; IKBKB; C1QA; C3 | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062128-afe67892 |
| h-6a4c716402 | TREM2-Driven Phagocytic Receptor Cascades Determine Mitochondrial Antigen Presen | 0.58 | 0.48 | TREM2 | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062132-5d93ddb2 |
| h-07691d28 | Oxygen Pressure-Dependent BDNF Cascade: DHHC2/PSD95 Stabilization for Synaptic R | 0.58 | 0.64 | | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-181340-8acb24dc |
| h-d645402b | ALOX15 Inhibition Combined with Selenium Augmentation for Synergistic Ferroptosi | 0.58 | 0.58 | ALOX15, SELENOP | proposed | 2026-04-17 | SDA-2026-04-16-gap-ferroptosis-als-d2fb6bf796ed |