| h-15b0ade220 | HIF1A stabilization lowers the activation threshold of circadian-disrupted micro | 0.57 | 0.71 | HIF1A | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062033-839c3e2a |
| h-1982f2d8bb | NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumulation | 0.57 | 0.71 | NLRP3 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-fcbc4065 | NLRP3 Inflammasome Blockade as Upstream Intervention to Prevent SASP Amplificati | 0.57 | 0.71 | NLRP3 | proposed | 2026-04-16 | SDA-2026-04-12-gap-debate-20260410-145418-c1527e7b |
| h-e7f5985c | ER Stress Reduction as Adjunctive Therapy to Support Autophagy | 0.57 | 0.68 | HFE (H63D variant) | promoted | 2026-04-16 | SDA-2026-04-15-gap-pubmed-20260411-092119-691e1977 |
| h-6cfb4671 | Vascular-Glial Interface Restoration | 0.57 | 0.71 | CLDN5 | proposed | 2026-04-14 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-13ef5927 | CX43 hemichannel engineering enables size-selective mitochondrial transfer | 0.57 | 0.55 | GJA1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-89432b95 |
| h-3a901ec3 | Astroglial Gap Junction Coordination via Connexin-43 Phosphorylation Modulation | 0.57 | 0.72 | GJA1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-ee5a5023 |
| h-04ec45fe92 | Synergistic enhancement of autophagy and lysosomal biogenesis by combined mTOR i | 0.57 | 0.52 | MTOR, TPCN2, TFEB | proposed | 2026-04-22 | SDA-2026-04-04-gap-lysosomal-cathepsin-ad |
| h-828b3729 | Temporal Gating of Microglial Responses | 0.57 | 0.20 | CLOCK, ARNTL | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-56ed2f6e37 | Astrocyte-PV Interneuron Metabolic Coupling as a Mediator of Aβ Vulnerability | 0.57 | 0.55 | MCT4/SLC16A4 | proposed | 2026-04-28 | SRB-2026-04-28-h-var-e95d2d1d86 |
| h-SDA-2026-04-26-gap | Circulating Endothelial Microparticles Expressing Activated LRP1 and CD31 Identi | 0.57 | 0.37 | PECAM1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-001521 |
| h-SDA-2026-04-26-gap | CSF p-tau217 Normalization Occurs Earlier Than Amyloid PET Negativity, Enabling | 0.57 | 0.35 | N/A (biomarker kinetics) | proposed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260417-033134-20519caa |
| h-c1f19a34 | A genetically encoded reporter for axonal mitochondrial protein import fidelity | 0.57 | 0.55 | TOM20, TOM40 (translocase complex); CHOP/DDIT3 (stress respo | proposed | 2026-04-26 | SDA-2026-04-10-gap-debate-20260410-075000-7396040a |
| h-b2706086 | Purine Salvage Pathway Flux as Neuroprotection Efficacy Marker | 0.57 | 0.35 | HPRT1 | proposed | 2026-04-17 | SDA-2026-04-04-gap-debate-20260403-222618-c698b06a |
| h-96795760 | H3K9me3 Heterochromatin Loss at Pericentromeric Repeats | 0.56 | 0.60 | H3K9me3 Heterochromatin | proposed | 2026-04-26 | SDA-2026-04-19-gap-epigenetic-comparative-ad-pd-als |
| h-var-3f7e16389b | GluN2B-Mediated Microglial Activation and Tau Propagation | 0.56 | 0.71 | GRIN2B | proposed | 2026-04-20 | SDA-2026-04-03-26abc5e5f9f2 |
| h-9ec34d6f | Circulating hs-CRP as Disease-Modifying Target via Microglial IL-1β Amplificatio | 0.56 | 0.50 | CRP → IL-1β → TLR4/MyD88 axis | proposed | 2026-04-26 | SDA-2026-04-16-frontier-immunomics-e6f97b29 |
| h-var-37b006000c | Ketone-Primed Thalamocortical Enhancement of Glymphatic Tau Clearance | 0.56 | 0.71 | GRIN2B | proposed | 2026-04-20 | SDA-2026-04-03-26abc5e5f9f2 |
| h-0ad03dd59c | TDP-43 Co-pathology Subtype Identified Through Motor Neuron Transcriptomics | 0.56 | 0.52 | TARDBP | proposed | 2026-04-28 | SDA-2026-04-28-gap-methodol-20260427-041425-9e73b245 |
| h-var-6e963ed4e6 | Closed-loop tACS targeting EC-II somatostatin interneurons to restore dendritic | 0.56 | 0.82 | SST | promoted | 2026-04-20 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-abcd9e77ce | Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons | 0.56 | 0.82 | PVALB | promoted | 2026-04-20 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-a496e5e122 | Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla | 0.56 | 0.82 | SST | superseded | 2026-04-20 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-dce97ca507 | Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla | 0.56 | 0.82 | AQP4 | promoted | 2026-04-17 | SDA-2026-04-03-26abc5e5f9f2 |
| h-4c3210de | Ancestry-Adapted Mitochondrial Rescue Therapy | 0.56 | 0.55 | PPARGC1A, NRF1, TFAM | proposed | 2026-04-12 | SDA-2026-04-04-gap-debate-20260403-222549-20260402 |
| h-e14a97bf | Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senescent Microglia to Pre | 0.56 | 0.72 | CDKN2A (p16^Ink4a), CDKN1A (p21^Cip1/Waf1) | promoted | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-075425-2feffb0c |
| h-763d9c478e | P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming | 0.56 | 0.45 | P2RX7/NLRP3 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062039-3b945972 |
| h-ba3a948a | Fractalkine Axis Amplification via CX3CR1 Positive Allosteric Modulators | 0.56 | 0.60 | CX3CR1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-691b42f1 |
| h-b3e97952 | C9orf72-SMCR8-WDR41 Complex Dysfunction in C9-ALS Rescued by PIKFYVE Inhibition | 0.56 | 0.50 | C9orf72/SMCR8/RAB7A/PIKFYVE | proposed | 2026-04-14 | SDA-2026-04-13-gap-pubmed-20260410-143119-8ae42941 |
| h-9ea3d9ea8c | TFEB-Mediated Lysosomal Biogenesis Restoration for GRN Haploinsufficiency FTD | 0.56 | 0.68 | TFEB/GRN | proposed | 2026-04-29 | SDA-2026-04-28-gap-test-20260425-224949 |
| h-7befe3ab58 | SIRT1 Activation Suppresses C9orf72-Mediated Neurodegeneration | 0.56 | 0.58 | SIRT1 | proposed | 2026-04-28 | SDA-TEST-PREREG-003 |
| h-36d21444fd | G2019S Amplifies Lysosomal Volume-Sensing Through Membrane Microdomain Partition | 0.56 | 0.45 | LRRK2,PI4P | proposed | 2026-04-26 | SDA-2026-04-23-gap-debate-20260417-033119-54941818 |
| h-fa11c9bd1e | HBOT (2.0 ATA, 60 min) activates TFEB-mediated autophagy-lysosome pathway to acc | 0.56 | 0.58 | TFEB (TFE2) | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-181340-8acb24dc-debate |
| h-5186801ea0 | SIRT3 loss creates a mitochondrial acetylation-stress loop that weakens antioxid | 0.56 | 0.58 | SIRT3; SOD2; IDH2; PPIF | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-181140-0af1a353-debate |
| h-2416d8f8d2 | Synaptic protection via microglial/complement normalization | 0.56 | 0.55 | TREM2/complement cascade | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-150544-e3a2eab9-debate |
| h-0f37721539 | BBB leak induces secondary pericyte senescence through TGF-beta-dominant stress | 0.56 | 0.42 | TGFB1, TGFBR2, SMAD2, SMAD3 | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-de5dfc4391 |
| h-71cd255f48 | Direct neuronal HDAC inhibition is unlikely to mediate therapeutic alpha-synucle | 0.56 | 0.71 | HDAC1/HDAC2 | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-18cce7b525 |
| h-a25bd0a027 | H3: Reelin Signaling Deficiency Uncouples Layer II Neurons from Grid Cell Coupli | 0.56 | 0.52 | RELN, LRP8, GSK3B | proposed | 2026-04-22 | SDA-2026-04-02-gap-ec-layer2-vulnerability |
| h-37ead784be | TFEB Activation Clears Tau-Loaded Endolysosomal Compartments, Preventing Release | 0.56 | 0.58 | TFEB | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-052358 |
| h-567197b279 | Persistent γH2AX+53BP1 Foci with DREAM Complex Activation Defines Irreversibly A | 0.56 | 0.65 | H2AFX (γH2AX), TP53BP1, DREAM complex (LIN9, LIN37, RBL2, E2 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-6af4ba5f |
| h-ff5951ff09 | Post-Translational Modification Codes Determine Interaction Specificity | 0.56 | 0.55 | G3BP1, PRMT1, PRMT5, ATM, ATR | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041428-53b81741 |
| h-e5f17434c3 | AQP4 Autoantibodies in NMOSD Cause Bystander Oligodendrocyte Injury via Metaboli | 0.56 | 0.52 | AQP4; SLC16A1 (MCT1); SLC16A3 (MCT4) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-ce0abc1e |
| h-cfcf4d4c0d | Temporal cGAS-STING Activation Stage-Specific Therapeutic Targeting | 0.56 | 0.48 | STING (TMEM173) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-fc60e018 |
| h-9f5ce0a588 | MOG-IgG induces spinal cord demyelination through Fcγ receptor-dependent macroph | 0.56 | 0.58 | MOG, FCGR1A, FCGR3A, FCGR2A, SYK, IRAK4 | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062111-e3e328bf |
| h-dd53a5c2 | GCH1/BH4 Axis Stabilization for Dual Ferroptosis and Mitochondrial Protection | 0.56 | 0.56 | GCH1, BH4 | proposed | 2026-04-17 | SDA-2026-04-16-gap-ferroptosis-als-d2fb6bf796ed |
| h-6be901fb | TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosomal Biogenesis | 0.56 | 0.58 | MCOLN1, PINK1, PARK2, TFEB, LRRK2 | promoted | 2026-04-16 | SDA-2026-04-16-gap-debate-20260410-113045-27c7b314 |
| h-b5723774 | Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuro | 0.56 | 0.65 | C1QA | promoted | 2026-04-15 | SDA-2026-04-14-gap-pubmed-20260410-191046-15921012 |
| h-var-1a318725cd | Real-time closed-loop transcranial focused ultrasound targeting PVALB interneuro | 0.56 | 0.71 | PVALB | promoted | 2026-04-21 | SDA-2026-04-03-26abc5e5f9f2 |
| h-e9b162c4 | AMPK Activation to Restore Autophagy and Clear α-Synuclein Aggregates | 0.56 | 0.40 | | proposed | 2026-04-18 | SDA-2026-04-17-gap-pubmed-20260410-145520-5692b02e |
| h-0343d1825e | Astrocyte Reactivity Subtype Targeting GABA Synthesis | 0.56 | 0.55 | GAD1 | proposed | 2026-04-28 | SDA-2026-04-28-gap-methodol-20260427-041425-9e73b245 |
| h-83efeed6 | Circadian-Gated Maresin Biosynthesis Amplification | 0.56 | 0.40 | ALOX12 | debated | 2026-04-02 | sda-2026-04-01-gap-014 |