| h-d7849fd300 | Closed-Loop Hippocampal TFUS for Gamma Network Target Engagement | 0.58 | 0.45 | CCK (cholecystokinin), TREK-1 (KCNK2), TRPV4 | proposed | 2026-04-28 | SRB-2026-04-28-h-var-a4975bdd96 |
| h-375c093a3f | APOE4 dual function: beneficial astrocyte anti-inflammatory signaling vs. pathog | 0.57 | 0.68 | APOE | proposed | 2026-04-27 | SDA-2026-04-12-gap-pubmed-20260410-184126-b2c3e2e8 |
| h-241752cd | CD38 Inhibition for NAD+ Restoration and Microglial Senescence Prevention | 0.57 | 0.55 | CD38 | proposed | 2026-04-25 | SDA-2026-04-17-gap-microglial-subtypes-pharmaco-202604170000 |
| h-d27b354c | Sequential TRPML1 Activation Following Autophagy Priming | 0.57 | 0.60 | MCOLN1 (TRPML1), ATG7 | promoted | 2026-04-16 | SDA-2026-04-16-gap-debate-20260410-113045-27c7b314 |
| h-0f00fd75 | HSP90-Tau Disaggregation Complex Enhancement | 0.57 | 0.53 | HSP90AA1 | archived | 2026-04-02 | SDA-2026-04-04-gap-tau-prop-20260402003221 |
| h-var-a4ec87f152 | TREM2-Senescence Cascade in Astrocyte-Microglia Communication Breakdown | 0.57 | 0.53 | TREM2 | promoted | 2026-04-21 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-analogy-90a0279a | Astrocyte-targeted LNP-APOE4 silencing to restore lipid homeostasis and suppress | 0.57 | 0.45 | APOE | active | 2026-04-28 | |
| h-var-58e76ac310 | Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to resto | 0.57 | 0.81 | PVALB | promoted | 2026-04-12 | SDA-2026-04-03-26abc5e5f9f2 |
| h-ea3274ff | TREM2-P2RY12 Balance Restoration Therapy | 0.57 | 0.30 | TREM2 | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-298d27a24f | Disease-Associated Microglia (DAM) Program Drives IBA1 Downregulation | 0.57 | 0.50 | TREM2/TYROBP | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041439-306c2cdb |
| h-35d17c0074 | VPS34 Complex I Subunit Heterogeneity Dictates Organelle-Specific vs. Bulk Autop | 0.57 | 0.55 | PIK3C3/VPS34, ATG14L, UVRAG, NRBF2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7 |
| h-var-b9a3903f4c | PINK1/PARK2-Mediated Mitophagy Enhancement for Neuroinflammation Control | 0.57 | 0.41 | PINK1 | promoted | 2026-04-20 | SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402 |
| h-b7ab85b6 | Neuronal Subtype-Specific Alpha-Synuclein Expression Normalization | 0.57 | 0.40 | SNCA | proposed | 2026-04-04 | SDA-BIOMNI-BINDER_D-0657a9ed |
| h-cee6b095 | REST Complex Dysregulation as Master Epigenetic Switch | 0.57 | 0.60 | REST | proposed | 2026-04-25 | SDA-2026-04-19-gap-epigenetic-comparative-ad-pd-als |
| h-7b7218698d | Blocking Exosomal Tau Uptake at Neuronal LRP1 Receptors Disrupts Interneuronal P | 0.57 | 0.60 | LRP1 | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-052358 |
| h-fd8eb2a065 | Blocking Astrocyte-Mediated Tau Re-Spreading via Cx43 Hemichannel Inhibition | 0.57 | 0.52 | GJA1 (Connexin-43) | proposed | 2026-04-22 | SDA-2026-04-04-gap-tau-prion-spreading |
| h-514ab2e42b | Hsp70-based therapy to prevent lysosomal membrane permeabilization and cathepsin | 0.57 | 0.55 | HSPA1A | proposed | 2026-04-22 | SDA-2026-04-04-gap-lysosomal-cathepsin-ad |
| h-eaee030e68 | CX3CR1-Negative Trem2-High Microglial Subset Mediates Female Resilience via Estr | 0.57 | 0.62 | ESR1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-ec89b1e4 |
| h-e047388d70 | LRP1-mediated synaptic uptake drives early entorhinal-hippocampal tau propagatio | 0.57 | 0.62 | LRP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062052-946439a8 |
| h-0eec787493 | Direct NF-κB Transcriptional Regulation of C1q Genes in Microglia | 0.57 | 0.58 | RELA; C1QA/C1QB/C1QC | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062128-afe67892 |
| h-5c618b582c | Brain-Ester Prodrug Strategy for CNS-Selective HDAC6 Inhibition | 0.57 | 0.65 | HDAC6 (class IIb histone deacetylase) | proposed | 2026-04-21 | SDA-2026-04-08-gap-debate-20260406-062039-47e9c8cf |
| h-var-2041072461 | TREM2-Dependent Microglial Surveillance Controls AQP4-Mediated Tau Clearance Thr | 0.57 | 0.71 | TREM2 | proposed | 2026-04-12 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-1906e102cf | Dual-Circuit Tau Vulnerability Cascade with Glial-Mediated Amplification | 0.57 | 0.65 | MAPT | proposed | 2026-04-07 | SDA-2026-04-03-26abc5e5f9f2 |
| h-06d5f49673 | Conserved G-Quadruplex Forming Potential in HOTAIR Defines Therapeutic Window | 0.57 | 0.52 | HOTAIR | proposed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075007-232fbf62 |
| h-e12109e3 | Tau-Independent Microtubule Stabilization via MAP6 Enhancement | 0.57 | 0.60 | MAP6 | debated | 2026-04-02 | sda-2026-04-01-gap-004 |
| h-4107efb8ea | Vascular and Perivascular Cell Type Vulnerability: BBB Integrity Disruption | 0.57 | 0.71 | CLDN5 | proposed | 2026-04-22 | SDA-2026-04-02-gap-seaad-debate-v4 |
| h-15b0ade220 | HIF1A stabilization lowers the activation threshold of circadian-disrupted micro | 0.57 | 0.71 | HIF1A | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062033-839c3e2a |
| h-1982f2d8bb | NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumulation | 0.57 | 0.71 | NLRP3 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-fcbc4065 | NLRP3 Inflammasome Blockade as Upstream Intervention to Prevent SASP Amplificati | 0.57 | 0.71 | NLRP3 | proposed | 2026-04-16 | SDA-2026-04-12-gap-debate-20260410-145418-c1527e7b |
| h-e7f5985c | ER Stress Reduction as Adjunctive Therapy to Support Autophagy | 0.57 | 0.68 | HFE (H63D variant) | promoted | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-092119-691e1977 |
| h-6cfb4671 | Vascular-Glial Interface Restoration | 0.57 | 0.71 | CLDN5 | proposed | 2026-04-13 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-13ef5927 | CX43 hemichannel engineering enables size-selective mitochondrial transfer | 0.57 | 0.55 | GJA1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-89432b95 |
| h-3a901ec3 | Astroglial Gap Junction Coordination via Connexin-43 Phosphorylation Modulation | 0.57 | 0.72 | GJA1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-ee5a5023 |
| h-04ec45fe92 | Synergistic enhancement of autophagy and lysosomal biogenesis by combined mTOR i | 0.57 | 0.52 | MTOR, TPCN2, TFEB | proposed | 2026-04-22 | SDA-2026-04-04-gap-lysosomal-cathepsin-ad |
| h-828b3729 | Temporal Gating of Microglial Responses | 0.57 | 0.20 | CLOCK, ARNTL | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-56ed2f6e37 | Astrocyte-PV Interneuron Metabolic Coupling as a Mediator of Aβ Vulnerability | 0.57 | 0.55 | MCT4/SLC16A4 | proposed | 2026-04-28 | SRB-2026-04-28-h-var-e95d2d1d86 |
| h-SDA-2026-04-26-gap | Circulating Endothelial Microparticles Expressing Activated LRP1 and CD31 Identi | 0.57 | 0.37 | PECAM1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-001521 |
| h-SDA-2026-04-26-gap | CSF p-tau217 Normalization Occurs Earlier Than Amyloid PET Negativity, Enabling | 0.57 | 0.35 | N/A (biomarker kinetics) | proposed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260417-033134-20519caa |
| h-c1f19a34 | A genetically encoded reporter for axonal mitochondrial protein import fidelity | 0.57 | 0.55 | TOM20, TOM40 (translocase complex); CHOP/DDIT3 (stress respo | proposed | 2026-04-26 | SDA-2026-04-10-gap-debate-20260410-075000-7396040a |
| h-b2706086 | Purine Salvage Pathway Flux as Neuroprotection Efficacy Marker | 0.57 | 0.35 | HPRT1 | proposed | 2026-04-16 | SDA-2026-04-04-gap-debate-20260403-222618-c698b06a |
| h-f801d7a726 | Small-Molecule Modulation of TDP-43 Liquid-Liquid Phase Separation for ALS/FTD | 0.56 | 0.50 | TARDBP | proposed | 2026-05-10 | SDA-2026-05-10-gap-test-20260425-224949 |
| h-96795760 | H3K9me3 Heterochromatin Loss at Pericentromeric Repeats | 0.56 | 0.60 | H3K9me3 Heterochromatin | proposed | 2026-04-25 | SDA-2026-04-19-gap-epigenetic-comparative-ad-pd-als |
| h-var-3f7e16389b | GluN2B-Mediated Microglial Activation and Tau Propagation | 0.56 | 0.71 | GRIN2B | proposed | 2026-04-20 | SDA-2026-04-03-26abc5e5f9f2 |
| h-9ec34d6f | Circulating hs-CRP as Disease-Modifying Target via Microglial IL-1β Amplificatio | 0.56 | 0.50 | CRP → IL-1β → TLR4/MyD88 axis | proposed | 2026-04-25 | SDA-2026-04-16-frontier-immunomics-e6f97b29 |
| h-var-37b006000c | Ketone-Primed Thalamocortical Enhancement of Glymphatic Tau Clearance | 0.56 | 0.71 | GRIN2B | proposed | 2026-04-20 | SDA-2026-04-03-26abc5e5f9f2 |
| h-0ad03dd59c | TDP-43 Co-pathology Subtype Identified Through Motor Neuron Transcriptomics | 0.56 | 0.52 | TARDBP | proposed | 2026-04-28 | SDA-2026-04-28-gap-methodol-20260427-041425-9e73b245 |
| h-var-6e963ed4e6 | Closed-loop tACS targeting EC-II somatostatin interneurons to restore dendritic | 0.56 | 0.82 | SST | promoted | 2026-04-20 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-abcd9e77ce | Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons | 0.56 | 0.82 | PVALB | promoted | 2026-04-20 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-a496e5e122 | Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla | 0.56 | 0.82 | SST | superseded | 2026-04-20 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-dce97ca507 | Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla | 0.56 | 0.82 | AQP4 | promoted | 2026-04-17 | SDA-2026-04-03-26abc5e5f9f2 |