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Hypotheses

2,362 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-f19b8ac8Complement-Mediated Synaptic Protection0.580.40C1QAdebated2026-04-04SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-45d23b07Multi-Biomarker Composite Index Surpassing Amyloid PET for Treatment Response Pr0.580.45COMPOSITE_BIOMARKERpromoted2026-04-17SDA-BIOMNI-BIOMARKE-34ec007c
h-6880f29bIGFBPL1-Mediated Microglial Reprogramming0.580.40IGFBPL1debated2026-04-04SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-var-fe8899ff37TREM2-Astrocyte Communication in Microglial Dysfunction0.580.53TREM2promoted2026-04-21SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-0bdc3803Spatial Transcriptome-Guided Precision Cell Therapy0.580.55SOX10 and DLX1/2proposed2026-04-04SDA-2026-04-03-gap-seaad-v2-20260402032945
h-8e3748fe5cChronic mTORC1-ULK1 signaling blocks autophagy initiation in irradiated pericyte0.580.49MTORproposed2026-04-26SDA-2026-04-26-gap-pubmed-20260410-193006-9525a13b-debate
h-fbc439901eNAD+/SARM1 Axis Provides Metabolic Feedback Coupling Mitophagy to ER-Phagy0.580.52SARM1 (SARM1), PARP1, SIRT1, SIRT3proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7
h-73e29e3aSynaptic Vesicle Tau Capture Inhibition0.580.34SNAP25archived2026-04-02SDA-2026-04-04-gap-tau-prop-20260402003221
h-665d562cbfAstrocyte reactivity subtypes in neurodegeneration — Rich Analysis Notebook shou0.580.52Astrocyteproposed2026-04-28SDA-2026-04-27-gap-methodol-20260427-035148-9ab1842d
h-50249eb28dMitochondrial transfer between neurons and glia — Rich Analysis Notebook should 0.580.52Mitochondrialproposed2026-04-28SDA-2026-04-27-gap-methodol-20260427-035148-7b3b3df4
h-bfcbb20cffTREM2 should remain under review until replicated0.580.52tauproposed2026-04-28AD-MASTER-PLAN-TREM2-20260428030753
h-f12d206863APOE should remain under review until replicated0.580.52tauproposed2026-04-28AD-MASTER-PLAN-APOE-20260428030754
h-1cfdb2339dBDNF should remain under review until replicated0.580.52tauproposed2026-04-28AD-MASTER-PLAN-BDNF-20260428030755
h-d6c8b66717GFAP should remain under review until replicated0.580.52tauproposed2026-04-28AD-MASTER-PLAN-GFAP-20260428030756
h-c092c61024LRP1 should remain under review until replicated0.580.52tauproposed2026-04-28AD-MASTER-PLAN-LRP1-20260428030757
h-9a9ad9ae54microglial priming across neurodegenerative diseases should remain under review 0.580.52C1QAproposed2026-04-28SDA-2026-04-28-microglial-priming-causal-nd
h-0452017800SciDEX debate-engine causal discovery benchmark should remain under review until0.580.52calibrationproposed2026-04-28SDA-causal-benchmark-20260428-035713
h-7204d85a33Mitochondrial transfer between neurons and glia — Rich Analysis Notebook should 0.580.52Mitochondrialproposed2026-04-28SDA-2026-04-28-gap-methodol-20260427-035148-7b3b3df4
h-d773e0bf21H4: Age-Related Hsp70 Chaperone Decline Blocks Granule Reversibility0.580.58HSPA1A/HSPA1B, DNAJB6, DNAJB8proposed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041428-4c4414ad
h-4c10f3df93TBK1 Phosphorylation State Creates Phospho-Regulated Peripheral Retention Thresh0.580.50TBK1proposed2026-04-21SDA-2026-04-08-gap-pubmed-20260406-041423-9c2c2ee3
h-var-0dd032612fDynamic Microglial Phenotype Switching Biomarker Panel for Neuroinflammatory Tre0.580.42TREM2promoted2026-04-20SDA-2026-04-16-gap-pubmed-20260410-192526-f2bbb9ab
h-7c80747eHepcidin-Iron Set Point Hypothesis0.580.55proposed2026-04-14SDA-2026-04-13-gap-pubmed-20260410-155308-2c6815fb
h-b6167641TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gamma Oscillations0.580.55TARDBP (TDP-43) / cryptic splice sites in GABAergic transcripromoted2026-04-13SDA-2026-04-13-gap-20260410-172514
h-dc505f6346TREM2 Promoter Silencing via DNA Hypermethylation0.580.68TREM2proposed2026-04-21SDA-2026-04-07-gap-debate-20260406-062045-56983337
h-d7849fd300Closed-Loop Hippocampal TFUS for Gamma Network Target Engagement0.580.45CCK (cholecystokinin), TREK-1 (KCNK2), TRPV4proposed2026-04-28SRB-2026-04-28-h-var-a4975bdd96
h-375c093a3fAPOE4 dual function: beneficial astrocyte anti-inflammatory signaling vs. pathog0.570.68APOEproposed2026-04-27SDA-2026-04-12-gap-pubmed-20260410-184126-b2c3e2e8
h-241752cdCD38 Inhibition for NAD+ Restoration and Microglial Senescence Prevention0.570.55CD38proposed2026-04-26SDA-2026-04-17-gap-microglial-subtypes-pharmaco-202604170000
h-d27b354cSequential TRPML1 Activation Following Autophagy Priming0.570.60MCOLN1 (TRPML1), ATG7promoted2026-04-16SDA-2026-04-16-gap-debate-20260410-113045-27c7b314
h-0f00fd75HSP90-Tau Disaggregation Complex Enhancement0.570.53HSP90AA1archived2026-04-02SDA-2026-04-04-gap-tau-prop-20260402003221
h-var-a4ec87f152TREM2-Senescence Cascade in Astrocyte-Microglia Communication Breakdown0.570.53TREM2promoted2026-04-21SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-analogy-90a0279aAstrocyte-targeted LNP-APOE4 silencing to restore lipid homeostasis and suppress0.570.45APOEactive2026-04-28
h-var-58e76ac310Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to resto0.570.81PVALBpromoted2026-04-12SDA-2026-04-03-26abc5e5f9f2
h-ea3274ffTREM2-P2RY12 Balance Restoration Therapy0.570.30TREM2debated2026-04-04SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-298d27a24fDisease-Associated Microglia (DAM) Program Drives IBA1 Downregulation0.570.50TREM2/TYROBPproposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041439-306c2cdb
h-35d17c0074VPS34 Complex I Subunit Heterogeneity Dictates Organelle-Specific vs. Bulk Autop0.570.55PIK3C3/VPS34, ATG14L, UVRAG, NRBF2proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7
h-var-b9a3903f4cPINK1/PARK2-Mediated Mitophagy Enhancement for Neuroinflammation Control0.570.41PINK1promoted2026-04-20SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402
h-b7ab85b6Neuronal Subtype-Specific Alpha-Synuclein Expression Normalization0.570.40SNCAproposed2026-04-04SDA-BIOMNI-BINDER_D-0657a9ed
h-cee6b095REST Complex Dysregulation as Master Epigenetic Switch0.570.60RESTproposed2026-04-26SDA-2026-04-19-gap-epigenetic-comparative-ad-pd-als
h-7b7218698dBlocking Exosomal Tau Uptake at Neuronal LRP1 Receptors Disrupts Interneuronal P0.570.60LRP1proposed2026-04-22SDA-2026-04-04-gap-20260404-052358
h-fd8eb2a065Blocking Astrocyte-Mediated Tau Re-Spreading via Cx43 Hemichannel Inhibition0.570.52GJA1 (Connexin-43)proposed2026-04-22SDA-2026-04-04-gap-tau-prion-spreading
h-514ab2e42bHsp70-based therapy to prevent lysosomal membrane permeabilization and cathepsin0.570.55HSPA1Aproposed2026-04-22SDA-2026-04-04-gap-lysosomal-cathepsin-ad
h-eaee030e68CX3CR1-Negative Trem2-High Microglial Subset Mediates Female Resilience via Estr0.570.62ESR1proposed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041439-ec89b1e4
h-e047388d70LRP1-mediated synaptic uptake drives early entorhinal-hippocampal tau propagatio0.570.62LRP1proposed2026-04-21SDA-2026-04-07-gap-debate-20260406-062052-946439a8
h-0eec787493Direct NF-κB Transcriptional Regulation of C1q Genes in Microglia0.570.58RELA; C1QA/C1QB/C1QCproposed2026-04-21SDA-2026-04-08-gap-pubmed-20260406-062128-afe67892
h-5c618b582cBrain-Ester Prodrug Strategy for CNS-Selective HDAC6 Inhibition0.570.65HDAC6 (class IIb histone deacetylase)proposed2026-04-21SDA-2026-04-08-gap-debate-20260406-062039-47e9c8cf
h-var-2041072461TREM2-Dependent Microglial Surveillance Controls AQP4-Mediated Tau Clearance Thr0.570.71TREM2proposed2026-04-12SDA-2026-04-03-26abc5e5f9f2
h-var-1906e102cfDual-Circuit Tau Vulnerability Cascade with Glial-Mediated Amplification0.570.65MAPTproposed2026-04-07SDA-2026-04-03-26abc5e5f9f2
h-06d5f49673Conserved G-Quadruplex Forming Potential in HOTAIR Defines Therapeutic Window0.570.52HOTAIRproposed2026-04-21SDA-2026-04-10-gap-debate-20260410-075007-232fbf62
h-e12109e3Tau-Independent Microtubule Stabilization via MAP6 Enhancement0.570.60MAP6debated2026-04-02sda-2026-04-01-gap-004
h-4107efb8eaVascular and Perivascular Cell Type Vulnerability: BBB Integrity Disruption0.570.71CLDN5proposed2026-04-22SDA-2026-04-02-gap-seaad-debate-v4
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