| h-aging-opc-elf2 | ELF2-Mediated OPC Epigenetic Drift Drives Region-Dependent Myelin Dysfunction | 0.51 | 0.55 | ELF2 | active | 2026-04-24 | aging-mouse-brain-2026-04-02 |
| h-2f032e79df | Circulating IBA1 Protein Absorption/Interference with Detection | 0.51 | 0.42 | AIF1/IBA1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041439-306c2cdb |
| h-4b6e8204bf | Epigenetic Dysregulation of APOE Microglial Expression | 0.51 | 0.55 | APOE | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-6ca2dbc5f0 | REST-like neuronal silencing programs suppress MAPT in severe proteostatic stres | 0.51 | 0.43 | REST | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260411-083749-7d0cea3d-debate |
| h-98ddffb4cd | PKM2 nuclear translocation bridges metabolism and inflammatory transcription in | 0.51 | 0.44 | PKM2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062033-839c3e2a |
| h-ecfaa2cbb2 | Parthenolide perturbs adenosine transport or metabolism upstream of ADORA2A | 0.51 | 0.46 | ADORA2A | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-193037-1dc5e03a-debate |
| h-315367de | TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Function by Suppressing IL- | 0.51 | 0.42 | TYRO3 | proposed | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-174607-708e8d91 |
| h-ea51415536 | TFUS-Gamma Entrainment Synergizes with Anti-Amyloid Immunotherapy | 0.51 | 0.42 | P2X7 (P2RX7), FcγRIIB (FCGR2B), TREM2, mGluR5 (GRM5) | proposed | 2026-04-28 | SRB-2026-04-28-h-var-a4975bdd96 |
| h-495454ef | Synthetic Biology Approach: Designer Mitochondrial Export Systems | 0.51 | 0.20 | Synthetic fusion proteins | proposed | 2026-04-02 | SDA-2026-04-01-gap-20260401231108 |
| h-var-a7d6fbbb00 | TREM2-Mediated Spatial Redistribution of Complement Regulators Controls Synaptic | 0.50 | 0.33 | TREM2 | proposed | 2026-04-26 | SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9 |
| h-28d5b559 | Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neuroprotection | 0.50 | 0.50 | TFAM, MT-CO1 | proposed | 2026-04-12 | SDA-2026-04-04-SDA-2026-04-04-gap-debate-20260403-222618-c69 |
| SDA-2026-04-02-gap-t | Trans-Synaptic Adhesion Molecule Modulation | 0.50 | 0.33 | NLGN1 | archived | 2026-04-16 | SDA-2026-04-04-gap-tau-prop-20260402003221 |
| h-3b463f9c27 | Stage-Dependent Biphasic SPP1 Targeting: Early Enhancement Followed by Late Inhi | 0.50 | 0.45 | SPP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062118-2cdbb0dd |
| h-177d9cb05108 | Disease-Elevated CHI3L1/CHIT1 Chitinases Are Biomarkers and Partial Compensators | 0.50 | 0.73 | CHI3L1 (YKL-40), CHIT1, CHI3L2 / MMP-2 / TREM2 / MerTK | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260425215446 |
| h-3294f3a8 | CCR2+ Monocyte Depletion as Restoration of CNS Immune Privilege | 0.50 | 0.45 | CCL2/CCR2 axis; specifically CCR2+ monocytes | proposed | 2026-04-25 | SDA-2026-04-16-frontier-immunomics-e6f97b29 |
| h-bc10d5f3fd | Downstream Pathway Selective Modulation: ITGAX (αXβ2) Integrin Blockade | 0.50 | 0.50 | ITGAX (CD11c) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062118-2cdbb0dd |
| h-ebf3cb4d54 | Glial-Specific Ferroptosis Resistance via GPX4 Enhancement Protects Motor Neuron | 0.50 | 0.45 | GPX4 | proposed | 2026-05-10 | SDA-2026-05-10-gap-test-20260425-224949 |
| h-4978202a55 | TDP-43 Phase Separation Destabilization Drives Cytoplasmic Aggregation | 0.50 | 0.58 | TDP-43 (TARDBP), PRMT5 | proposed | 2026-05-03 | SDA-2026-05-03-gap-test-20260425-224949 |
| cff6d01d-d3d4-4a09-9 | Test hypothesis 1 | 0.50 | 0.32 | | proposed | 2026-04-27 | |
| e27e9fa0-7915-4b55-a | Test hypothesis 1 | 0.50 | 0.32 | | proposed | 2026-04-27 | |
| f2cde881-ad97-4c0c-8 | Test hypothesis 1 | 0.50 | 0.32 | | proposed | 2026-04-27 | |
| 489b30cf-2825-4058-a | Test hypothesis 1 | 0.50 | 0.32 | | proposed | 2026-04-27 | |
| h-var-95b0f9a6bc-pro | Glymphatic-Mediated Tau Clearance Dysfunction (Proteomics DE) | 0.50 | 0.52 | MAPT | proposed | 2026-04-26 | |
| h-11ba42d0-cel | APOE4-Specific Lipidation Enhancement Therapy (Cell-Cell Communication) | 0.50 | 0.39 | APOE | proposed | 2026-04-26 | SDA-BIOMNI-CELL_CEL-a7eed9c5 |
| h-89f2d5ab82 | Mitochondrial-Targeted PINK1/Parkin Pathway Activation for Neuroprotection | 0.50 | 0.68 | PINK1/PRKN | proposed | 2026-04-26 | test-hypothesis-fixtures-v1 |
| h-f3eff15058ab | MAP6-mediated microtubule stabilization as therapeutic target | 0.50 | 0.50 | MAP6 | proposed | 2026-04-25 | |
| h-0ad79cf81a | Astrocyte-Neuron Lactate Shuttle (H6): Metabolic Coupling Restoration | 0.50 | 0.52 | SLC16A1 (MCT1 monocarboxylate transporter 1) | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-180918-962b1ada-debate |
| h-cf07e38ecd | Synergistic reduction of amyloid-tau interaction through secondary effects | 0.50 | 0.65 | BACE1/GSK3β | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-150544-e3a2eab9-debate |
| h-c573394de8 | APOE4 astrocytes fail to supply sufficient cholesterol to parvalbumin interneuro | 0.50 | 0.48 | LDLR, LRP8 (ApoER2), APOE | proposed | 2026-04-22 | SDA-2026-04-04-gap-apoe4-lipid-metabolism |
| h-1487c2bad4 | Early Postnatal TGF-beta Signaling Establishes Lifelong Regional Vulnerability T | 0.50 | 0.55 | TGFBR1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-ec89b1e4 |
| h-929aef3ac1 | Modulation of G3BP1 Intrinsically Disordered Region Solvation Free Energy | 0.50 | 0.52 | G3BP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041423-2d1db50c |
| h-be723cd406 | Selectively Inhibit Maladaptive AQP4-Driven Astrocyte-Microglia Inflammatory Sig | 0.50 | 0.45 | AQP4, NFKB1, IL1B, TNF | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-7e1dc0b2 |
| h-c92fabed93 | Shift AQP4 Isoform/OAP Assembly Toward Clearance-Competent Autoantibody-Less-Clu | 0.50 | 0.48 | AQP4-M1, AQP4-M23 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-7e1dc0b2 |
| h-4898d2a838 | Autophagy-Lysosomal Flux Impairment Preventing Pathological TDP-43 Clearance | 0.50 | 0.48 | TFEB, LAMP1, LAMP2, GABARAPL1, CTSD | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062202-c8c5a9a1 |
| h-0cc354f674 | Nuclear Pore and Nucleocytoplasmic Transport Machinery as Gatekeepers | 0.50 | 0.48 | NXF1, NXT1, XPO1, KPNA, RAN | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041428-53b81741 |
| h-a74317ce69 | LRP1 Loss-of-Function Derepresses P2RY12 Expression | 0.50 | 0.50 | LRP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041434-a4d6154a |
| h-b2fd6e79d1 | Nucleolar p21-rRNA Co-Aggregation as Irreversible Senescence Gate | 0.50 | 0.48 | NCL, FBL, AMBRA1, CDKN1A | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062101-724971bc |
| h-92a91b35a0 | NETosis Amplification by C1Q in Plaque Neutrophils | 0.50 | 0.45 | C1QA/C1QC | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062122-b65f8ebc |
| h-f5d32997 | SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression Re-enables SPM Precur | 0.50 | 0.50 | MFSD2A / SIRT1 (deacetylase activator axis) | proposed | 2026-04-13 | SDA-2026-04-12-gap-debate-20260410-113110-2059f65f |
| h-d9c5a529 | Alectinib-C1q Complex Hijacks TREM2's Synaptic Protective Binding Interface | 0.50 | 0.45 | C1QA/C1QB/C1QC, TREM2 | proposed | 2026-04-16 | SDA-2026-04-16-gap-pubmed-20260410-095709-4e97c09e |
| h-1e2405e1 | Cholinergic Attention Modulation Hypothesis | 0.50 | 0.40 | CHRNA7 | archived | 2026-04-12 | SDA-2026-04-04-gap-debate-20260403-222510-20260402 |
| h-var-7b5e9a60eb | TREM2-Mediated Microglial Dysfunction Drives Tau-Induced Blood-Brain Barrier Bre | 0.50 | 0.67 | TREM2 | proposed | 2026-04-21 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-be69d8af79 | TBK1 Loss Drives Microglial Senescence-SASP to Generate MMP-9-Mediated TDP-43 C- | 0.50 | 0.34 | TBK1 | proposed | 2026-04-27 | SDA-2026-04-26-gap-20260425215446 |
| h-var-75cc30ad27 | Astrocytic Complement Regulator Secretion Modulates Synaptic Vulnerability (CD55 | 0.50 | 0.33 | CD55 (DAF), CD46 (MCP) | proposed | 2026-04-26 | SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9 |
| h-var-244d3d8d08 | LDLR-Targeted Anti-Inflammatory Antibody Delivery for Neuroinflammation Suppress | 0.50 | 0.53 | LDLR | proposed | 2026-04-26 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-c86acecdaa | Neurogranulin Predicts p-tau217 Reliability by Identifying Patients with Intact | 0.50 | 0.42 | NRGN | proposed | 2026-04-25 | |
| h-df4e435ebf | RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-miR-6361 duplex | 0.50 | 0.39 | TARDBP/FUS/HNRNPA2B1 | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| h-var-3d720b9066 | Aggregation-prone sequences trigger HSP90-dependent conformational triage throug | 0.50 | 0.35 | HSP90AA1, HSP90AB1, CDC37, AKT1 | proposed | 2026-04-26 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| h-a11f71b5 | Conditional CRISPR Kill Switches for Aberrant Protein Clearance | 0.50 | 0.30 | UBE3A, PARK2, PINK1 | archived | 2026-04-04 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-130ad9483e | TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through | 0.50 | 0.48 | SPP1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-062118-5e49e14f |