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Hypotheses

2,369 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-be723cd406Selectively Inhibit Maladaptive AQP4-Driven Astrocyte-Microglia Inflammatory Sig0.500.45AQP4, NFKB1, IL1B, TNFproposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041445-7e1dc0b2
h-c92fabed93Shift AQP4 Isoform/OAP Assembly Toward Clearance-Competent Autoantibody-Less-Clu0.500.48AQP4-M1, AQP4-M23proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041445-7e1dc0b2
h-4898d2a838Autophagy-Lysosomal Flux Impairment Preventing Pathological TDP-43 Clearance0.500.48TFEB, LAMP1, LAMP2, GABARAPL1, CTSDproposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062202-c8c5a9a1
h-0cc354f674Nuclear Pore and Nucleocytoplasmic Transport Machinery as Gatekeepers0.500.48NXF1, NXT1, XPO1, KPNA, RANproposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041428-53b81741
h-a74317ce69LRP1 Loss-of-Function Derepresses P2RY12 Expression0.500.50LRP1proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041434-a4d6154a
h-b2fd6e79d1Nucleolar p21-rRNA Co-Aggregation as Irreversible Senescence Gate0.500.48NCL, FBL, AMBRA1, CDKN1Aproposed2026-04-21SDA-2026-04-07-gap-debate-20260406-062101-724971bc
h-92a91b35a0NETosis Amplification by C1Q in Plaque Neutrophils0.500.45C1QA/C1QCproposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062122-b65f8ebc
h-f5d32997SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression Re-enables SPM Precur0.500.50MFSD2A / SIRT1 (deacetylase activator axis)proposed2026-04-13SDA-2026-04-12-gap-debate-20260410-113110-2059f65f
h-d9c5a529Alectinib-C1q Complex Hijacks TREM2's Synaptic Protective Binding Interface0.500.45C1QA/C1QB/C1QC, TREM2proposed2026-04-17SDA-2026-04-16-gap-pubmed-20260410-095709-4e97c09e
h-1e2405e1Cholinergic Attention Modulation Hypothesis0.500.40CHRNA7archived2026-04-12SDA-2026-04-04-gap-debate-20260403-222510-20260402
h-var-7b5e9a60ebTREM2-Mediated Microglial Dysfunction Drives Tau-Induced Blood-Brain Barrier Bre0.500.67TREM2proposed2026-04-21SDA-2026-04-03-26abc5e5f9f2
h-var-be69d8af79TBK1 Loss Drives Microglial Senescence-SASP to Generate MMP-9-Mediated TDP-43 C-0.500.34TBK1proposed2026-04-27SDA-2026-04-26-gap-20260425215446
h-var-75cc30ad27Astrocytic Complement Regulator Secretion Modulates Synaptic Vulnerability (CD550.500.33CD55 (DAF), CD46 (MCP)proposed2026-04-27SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9
h-var-244d3d8d08LDLR-Targeted Anti-Inflammatory Antibody Delivery for Neuroinflammation Suppress0.500.53LDLRproposed2026-04-27SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-c86acecdaaNeurogranulin Predicts p-tau217 Reliability by Identifying Patients with Intact 0.500.42NRGNproposed2026-04-25
h-df4e435ebfRNA-binding proteins stabilize or gate the lncRNA-0021:mmu-miR-6361 duplex0.500.39TARDBP/FUS/HNRNPA2B1proposed2026-04-26SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate
h-var-3d720b9066Aggregation-prone sequences trigger HSP90-dependent conformational triage throug0.500.35HSP90AA1, HSP90AB1, CDC37, AKT1proposed2026-04-27SDA-2026-04-10-gap-debate-20260410-075012-32bac138
h-a11f71b5Conditional CRISPR Kill Switches for Aberrant Protein Clearance0.500.30UBE3A, PARK2, PINK1archived2026-04-04SDA-2026-04-03-gap-crispr-neurodegeneration-20260402
h-130ad9483eTREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through0.500.48SPP1proposed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-062118-5e49e14f
h-ed41a306c5VDAC1 Hyper-Oligomerization via Direct TDP-43 Binding0.500.45VDAC1, VDAC2proposed2026-04-21SDA-2026-04-08-gap-pubmed-20260406-062141-739c7f1c
h-var-80a3b3dd52Temporal NLRP3 Inhibition via SPP1-Mediated Mitophagy Enhancement During Critica0.500.39NLRP3promoted2026-04-21SDA-2026-04-15-gap-pubmed-20260406-062118-e3613755
h-var-f19f044a9aTREM2-Mediated Microglial Metabolic Reprogramming Accelerates Tau Pathological S0.490.67TREM2proposed2026-04-21SDA-2026-04-03-26abc5e5f9f2
h-b97e6bb5f1Lamin B1 Degradation as Irreversibility Gate0.490.52LMNB1, LMNB2, NCOA4, SQSTM1proposed2026-04-21SDA-2026-04-07-gap-debate-20260406-062101-724971bc
h-f11788656bYAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1 Transcription in Pe0.490.42SPP1proposed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-062118-5e49e14f
h-var-bee1a6239cGluN2B-Regulated Microglial Phagocytosis of Tau Aggregates via CX3CR1 Signaling0.490.67GRIN2Bproposed2026-04-21SDA-2026-04-03-26abc5e5f9f2
h-6b489d1deeAutophagy Enhancement via mTOR Inhibition for C9orf72 Dipeptide Repeat Pathology0.490.55MTOR/C9orf72proposed2026-04-29SDA-2026-04-28-gap-test-20260425-224949
h-f9e4985929Tumor-derived extracellular vesicles as TREM2 ligands0.490.45TREM2 ligands on tumor EVsproposed2026-04-26SDA-2026-04-26-gap-pubmed-20260410-150544-e3a2eab9-debate
h-a0bd8d4f4cReactive astrocyte glutamate-handling failure sustains dendritic tau-associated 0.490.47SLC1A2,GRIN2B,MAPTproposed2026-04-25SDA-2026-04-25-gapdebate-98a600b3ed
h-588406cca9G3BP1-TDP-43 Cross-Seeding Drives Co-Aggregation That Prion-Spreads Across Neura0.490.52TARDBPproposed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041428-e14e6524
h-6be018d35aTestosterone-Derived DHT Amplifies Microglial Androgen Receptor Signaling Drivin0.490.52ARproposed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041439-ec89b1e4
h-373fac84b5P2RY12/P2RY13 Purinergic Receptor Metabolic Rewiring0.490.48P2RY12, P2RY13, CTNNB1 (β-catenin), GSK3βproposed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-062118-e3613755
h-c40be3e018OPA1-Mediated Cristae Architecture Vulnerability0.490.48OPA1, MFN1/2, DRP1 (DNM1L), mitochondrial protease cleavage proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062141-611cf046
h-23cba4e15dTargeting AQP4 Sumoylation to Enhance Glymphatic Clearance as Therapeutic Strate0.490.44AQP4; SENP1; SENP2; UBC9proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041445-ce0abc1e
h-45b0992fc4Mitochondrial Proteostasis Hijacking0.490.52TOMM40proposed2026-04-21SDA-2026-04-08-gap-pubmed-20260406-062202-5c32c50a
h-6f6f920e83Sulfated glycans and metal-binding CSF proteins brace alpha-synuclein fibril pol0.490.42SNCAproposed2026-04-26SDA-2026-04-26-gap-pubmed-20260411-081644-1d2624b8-debate
h-a976bf02b0Structured Intronic Scaffold Regions in Enhancer-dilncRNAs Enable Cell-Type Sele0.490.42ECEPs (PAX6-AS1, KCNC2-AS1)proposed2026-04-21SDA-2026-04-10-gap-debate-20260410-075007-232fbf62
h-var-3993e74fb3C1q-Mediated Delivery of miR-33 Antisense Oligonucleotides for Enhanced APOE4 Li0.490.36miR-33a/miR-33bpromoted2026-04-20SDA-2026-04-16-gap-debate-20260410-113104-a13caf2e
h-var-8c9cecfc00SREBP-2 Direct Inhibition Hyper-Lipidation Strategy0.490.36SREBF2/ABCA1promoted2026-04-20SDA-2026-04-16-gap-debate-20260410-113104-a13caf2e
h-4b91b4b2d5Hyperphosphorylated TDP-43 Traps TRIM21 Into Inactive Complexes0.490.48TARDBP, TRIM21proposed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041423-3a6aa4ab
h-92a69aa3USP14 Inhibition to Accelerate Proteasomal Degradation of Synaptic Substrates0.490.46USP14 (ubiquitin-specific peptidase 14)proposed2026-04-26SDA-2026-04-16-frontier-proteomics-1c3dba72
h-3a0c21057eKinesin-Dependent Peripheral Microtubule Transport Maintains Receptor Exclusion 0.490.42KIF5B/KIF5Cproposed2026-04-21SDA-2026-04-08-gap-pubmed-20260406-041423-9c2c2ee3
h-var-73142bada1APOE4 Structural Remodeling via HSP70 Chaperone Enhancement Strategy0.490.37HSP70/APOE4promoted2026-04-21SDA-2026-04-16-gap-debate-20260410-113104-a13caf2e
h-2a1a95c1Oligodendrocyte Progenitor Cell Metabolic Reprogramming0.490.40PDK1, PFKFB3, LDHAarchived2026-04-04SDA-2026-04-03-gap-debate-20260403-222543-20260402
h-SDA-2026-04-26-gapSoluble LRP1 Fragments Serve as Blood-Based Indicators of Impaired Aβ Efflux and0.490.30LRP1proposed2026-04-26SDA-2026-04-26-gap-20260426-001521
h-SDA-2026-04-26-gapPlasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables L0.490.30NEFLproposed2026-04-26SDA-2026-04-26-gap-20260426-001521
h-a3f785dfSonic hedgehog pathway compartmentalization as quantitative biomarker for neuron0.490.45ADCY3 (adenylate cyclase), ARL13B (ciliary targeting), GNAI1proposed2026-04-26SDA-2026-04-10-gap-debate-20260410-075000-7396040a
h-var-71a27b2aa2TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inflammasome Regulation0.480.40TFEBpromoted2026-04-21SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402
h-var-fe9c7bfb0cGluN2B-Mediated Perivascular Pericyte Control of Glymphatic Tau Clearance0.480.67GRIN2Bproposed2026-04-21SDA-2026-04-03-26abc5e5f9f2
h-var-45ec9caaa4PINK1/PARK2-LC3 Mitophagy Enhancement0.480.40PINK1promoted2026-04-21SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402
h-f86127b5HDAC6 Inhibition for Dual Restoration of Microtubule Stability and Autophagic Ta0.480.52HDAC6proposed2026-04-13SDA-2026-04-13-gap-debate-20260412-094612-a2e3bd09
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