| h-332083afc1 | Sleep-Stage TFUS to Restore SWR-Gamma Coupling and Memory Consolidation | 0.53 | 0.40 | CB1 (CNR1), HCN1, Kv3.1 (KCNC1) | proposed | 2026-04-28 | SRB-2026-04-28-h-var-a4975bdd96 |
| h-c7350d53bb | Gut-derived butyrate reprograms microglia for amyloid clearance via HDAC2 inhibi | 0.53 | 0.72 | HDAC2 | proposed | 2026-04-27 | sda-2026-04-01-003 |
| h-2b545285ee | Glucosylceramide accumulation nucleates alpha-synuclein aggregation via lipid ra | 0.53 | 0.72 | GBA | proposed | 2026-04-27 | sda-2026-04-01-002 |
| h-64e3588957 | TREM2 Epigenetic Window for Microglial Lipid Metabolism | 0.53 | 0.55 | TREM2/HDAC1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062039-7ef9980b |
| h-1e2b7f1c | VPS35 Retromer Restoration to Rescue Endosomal Protein Trafficking | 0.52 | 0.53 | VPS35 (VPS26/VPS29/VPS35 complex) | proposed | 2026-04-26 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-0aecd2de | Pharmacogenomic CNS Drug Optimization Platform | 0.52 | 0.80 | CYP450 enzymes, transporters, and drug targets | promoted | 2026-04-12 | SDA-2026-04-04-gap-debate-20260403-222549-20260402 |
| h-c32ed9ee29 | Microglial Reactivation Status Modifies Amyloid Clearance and p-tau217 Normaliza | 0.52 | 0.45 | TREM2 | proposed | 2026-04-25 | |
| h-50ee9ed1ea | Circadian Clock Epigenetic Desynchronization Window | 0.52 | 0.52 | BMAL1/HDAC3 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062039-7ef9980b |
| h-var-31dc5b3ecb | TREM2-Dependent Microglial Control of Thalamocortical-Glymphatic Tau Clearance | 0.52 | 0.67 | TREM2 | proposed | 2026-04-21 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-cf5d8c96cb | TFEB Activation to Restore Lysosomal Biogenesis in Alzheimer's Disease Neuronal | 0.52 | 0.26 | TFEB | proposed | 2026-04-27 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-23b49dc7d3 | Charge-Pattern Asymmetry Creates Electrostatic Recruitment Gates | 0.52 | 0.58 | 53BP1/TP53BP1 | proposed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075026-23501c3c |
| h-2ae232e9fa | C1q Binding to Specific Synaptic Proteomes via Neurexin/Neuroligin Complexes | 0.52 | 0.55 | NRXN1, NLGN1 (Neuroligin 1) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9 |
| h-985b8091 | TREM2 Agonism to Redirect Microglia from Synaptic Pruning to OPTN-Deficient Neur | 0.52 | 0.52 | TREM2 | proposed | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-183548-043c7918 |
| h-d0c592780a | Gamma/tFUS Entrainment as Biomarker Modulator of Neuroinflammation, Amyloid, and | 0.52 | 0.55 | APOE, TREM2 (exploratory only); NF-κB, TNF-α, IL-1β, IL-6 | proposed | 2026-04-28 | SRB-2026-04-28-h-var-b7e4505525 |
| h-metrep-62c3fd1de1b | SASP Transient Suppression vs. Senolytic Elimination: A Therapeutic Tradeoff Ana | 0.52 | 0.75 | IL6,IL6R,GP130,STAT3,JAK1,JAK2,TNF,IL1B,CCL2,BDNF,VEGFA | proposed | 2026-04-28 | |
| h-7193c13952 | Synaptic NMDAR Subtype Targeting Prevents Excitotoxicity | 0.52 | 0.55 | GRIN2A/GRIN2B | proposed | 2026-04-28 | SDA-TEST-PREREG-003 |
| h-04780f23 | Neuronal Hypersensitivity to Feedback Inhibition by p62/Sequestosome-1 Accumulat | 0.52 | 0.50 | SQSTM1 (p62), mTORC1, TRAF6 | proposed | 2026-04-26 | SDA-2026-04-07-gap-pubmed-20260406-062212-ca78691c |
| h-2d5e4bc423 | HBOT at 2.0 ATA for 60 minutes restores PGC-1α-mediated mitochondrial biogenesis | 0.52 | 0.55 | PPARGC1A (PGC-1α) | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-181340-8acb24dc-debate |
| h-b701c493b0 | Dysregulated microglial glycolysis via HIF1α activation shifts the balance from | 0.52 | 0.58 | HIF1A, LDHA, LDHB, PKM2, TREM2, AMPK/mTOR | proposed | 2026-04-22 | SDA-2026-04-02-gap-synaptic-pruning-microglia |
| h-8be48c7cc2 | Inhibitory Neuron Subtype Loss: Excitation/Inhibition Imbalance Hypothesis | 0.52 | 0.50 | GAD1/GAD2 | proposed | 2026-04-22 | SDA-2026-04-02-gap-seaad-debate-v4 |
| h-579343d94c | Restoring AQP4 Astrocyte Polarization Enhances Glymphatic Tau Clearance and Limi | 0.52 | 0.52 | AQP4 | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-052358 |
| h-d93e5da83c | AAV-PHP.eB-Medium OSK Expression Reverses Cortical Neuronal Epigenetic Age Witho | 0.52 | 0.58 | OCT4/SOX2/KLF4 (OSK)/Epigenetic clock | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-060512 |
| h-7385cc8798 | Therapeutic Window Exists Through Activity-Dependent Regulation of Synaptic Vesi | 0.52 | 0.52 | VAMP2, VAMP3, Complexin-1/2, Munc13-1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062052-7bcf4b6c |
| h-2ef151e6f1 | Severely Depleted mtDNA and Impaired OXPHOS Defines Senescent Microglia | 0.52 | 0.58 | MT-ND1, MT-CO1, TFAM, SIRT3 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-6af4ba5f |
| h-43213d5e0f | GATA4 Stabilization and NF-κB Co-activation Identifies Senescent Microglia | 0.52 | 0.55 | GATA4, SQSTM1/p62, NFKB subunits | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-6af4ba5f |
| h-ef5e4c21ff | Loss of Nuclear Lamin B1 Distinguishes Senescent Microglia from Inflammatory Act | 0.52 | 0.60 | LMNB1 (Lamin B1) | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-6af4ba5f |
| h-f70d50d17e | Mitochondrial DNA Damage and cGAS-STING Activation Induces Microglial Senescence | 0.52 | 0.55 | CGAS/STING1/TMEM173 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e |
| h-0c6d0bb791 | Telomere Attrition and DNA Damage Response Activation Induces Microglial Senesce | 0.52 | 0.58 | TP53/CDKN2A/CDKN1A/ATM/ATR | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e |
| h-17dddb7a6a | Basal cGAS Derepression as Stratification Biomarker | 0.52 | 0.52 | cGAS promoter (CGAS), DNMT1, H3K9me3/Polycomb complex | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-611cf046 |
| h-b08fbcfeb6 | miR-143/145 Cluster Dysregulation Derepresses P2RY12 Transcription | 0.52 | 0.45 | MIR143, MIR145, KLF4 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041434-a4d6154a |
| h-afa87d4671 | M-Sec/TNTA2-mediated tunneling nanotube formation drives glia-neuron tau propaga | 0.52 | 0.56 | TNFAIP2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062052-946439a8 |
| h-76e3baa925 | Nucleocytoplasmic Transport Disruption | 0.52 | 0.55 | NUP107 | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062202-5c32c50a |
| h-6c20b3450d | HDAC1/2 Complex Restoration Corrects Age-Related Histone Hypoacetylation | 0.52 | 0.55 | HDAC1; HDAC2 | proposed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| h-2a31d5df00 | TSPO PET Kinetic Modeling for Priming State Discrimination | 0.52 | 0.55 | TSPO | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062039-3b945972 |
| h-7a8d7379 | Piezoelectric Nanochannel BBB Disruption | 0.52 | 0.10 | CLDN5, OCLN | debated | 2026-04-02 | sda-2026-04-01-gap-008 |
| h-aging-hippo-cortex | Hippocampal-Cortical Transcriptomic Divergence Reveals Accelerated Neurodegenera | 0.52 | 0.70 | CDKN2A | active | 2026-04-24 | aging-mouse-brain-2026-04-02 |
| h-var-5cc4b6d5db | CD33-Dependent Switch Hypothesis: CD33 Antagonism Redirects SPP1 Signaling from | 0.52 | 0.34 | CD33 | proposed | 2026-04-27 | SDA-2026-04-07-gap-pubmed-20260406-062118-2cdbb0dd |
| h-var-28394c8ce5 | LRP1-Mediated Endosomal Escape Enhancement Strategy | 0.52 | 0.53 | LDLR | proposed | 2026-04-27 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-ec9e48df | NRF2 Activation to Counteract Oxidative Stress from RGS6 Deficiency | 0.52 | 0.45 | | proposed | 2026-04-18 | SDA-2026-04-17-gap-pubmed-20260410-145520-5692b02e |
| h-fa757ac897 | Membrane interfacial selectivity for lipid-anchored pathologic conformers | 0.52 | 0.52 | SNCA, HSPA8, DNAJB6 | proposed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| h-15aa6d36c0 | Metabolic Accumulation (Ammonia/Manganese) Triggers IBA1 Downregulation via NRF2 | 0.52 | 0.48 | NRF2/NFE2L2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041439-306c2cdb |
| h-var-3049fa9ae4 | Cerebrospinal NFL-Triggered Liposome Dosing Maximizes lncRNA-0021 Therapeutic Wi | 0.52 | 0.39 | CSF NFL (biomarker), lncRNA-0021, synthetic liposomes | promoted | 2026-04-20 | SDA-2026-04-16-gap-pubmed-20260410-150509-76c40dac |
| h-aging-h5-regional- | Hippocampus ages transcriptionally faster than cerebellum, defining a regional v | 0.52 | 0.80 | CLU | open | 2026-04-23 | aging-mouse-brain-2026-04-02 |
| h-e0183502 | Vocal Cord Neuroplasticity Stimulation | 0.52 | 0.30 | CHR2/BDNF | debated | 2026-04-02 | sda-2026-04-01-gap-012 |
| h-SDA-2026-04-26-gap | Synergistic Timing With Acetylcholinesterase Inhibitors | 0.52 | 0.38 | MT1/MT2; AChE; CHRM1 (M1 muscarinic); BACE1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260411-090734-1be1b913 |
| h-SDA-2026-04-26-gap | Matrix Metalloproteinase-9-Mediated Claudin-5 Cleavage Drives Early Tight Juncti | 0.52 | 0.28 | MMP9 | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-001521 |
| h-65b79f09 | ApoE4-Mediated Failure of Cholesterol Efflux as Memory Maintenance Mechanism | 0.52 | 0.45 | APOE (ApoE4 isoform) → cholesterol metabolism | proposed | 2026-04-26 | SDA-2026-04-08-gap-debate-20260406-062033-ad87c3fb |
| h-05e92f66f1 | CSF p-tau217 Normalization Requires Intact Synaptic Function and BBB Integrity ( | 0.52 | 0.45 | NA - Patient stratification factor | proposed | 2026-04-25 | |
| h-test-8d254307 | EV-Mediated Epigenetic Reprogramming | 0.51 | 0.50 | EVs/miRNAs | archived | 2026-04-11 | sda-2026-04-12-ev-ad-biomarkers |
| h-929f356e | GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to Reduce Neuroinflammat | 0.51 | 0.55 | GAS6/TAM receptor complex | proposed | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-174607-708e8d91 |