| h-ef5e4c21ff | Loss of Nuclear Lamin B1 Distinguishes Senescent Microglia from Inflammatory Act | 0.52 | 0.60 | LMNB1 (Lamin B1) | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-6af4ba5f |
| h-43213d5e0f | GATA4 Stabilization and NF-κB Co-activation Identifies Senescent Microglia | 0.52 | 0.55 | GATA4, SQSTM1/p62, NFKB subunits | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-6af4ba5f |
| h-2ef151e6f1 | Severely Depleted mtDNA and Impaired OXPHOS Defines Senescent Microglia | 0.52 | 0.58 | MT-ND1, MT-CO1, TFAM, SIRT3 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-6af4ba5f |
| h-f70d50d17e | Mitochondrial DNA Damage and cGAS-STING Activation Induces Microglial Senescence | 0.52 | 0.55 | CGAS/STING1/TMEM173 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e |
| h-0c6d0bb791 | Telomere Attrition and DNA Damage Response Activation Induces Microglial Senesce | 0.52 | 0.58 | TP53/CDKN2A/CDKN1A/ATM/ATR | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e |
| h-17dddb7a6a | Basal cGAS Derepression as Stratification Biomarker | 0.52 | 0.52 | cGAS promoter (CGAS), DNMT1, H3K9me3/Polycomb complex | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-611cf046 |
| h-b08fbcfeb6 | miR-143/145 Cluster Dysregulation Derepresses P2RY12 Transcription | 0.52 | 0.45 | MIR143, MIR145, KLF4 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041434-a4d6154a |
| h-afa87d4671 | M-Sec/TNTA2-mediated tunneling nanotube formation drives glia-neuron tau propaga | 0.52 | 0.56 | TNFAIP2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062052-946439a8 |
| h-76e3baa925 | Nucleocytoplasmic Transport Disruption | 0.52 | 0.55 | NUP107 | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062202-5c32c50a |
| h-6c20b3450d | HDAC1/2 Complex Restoration Corrects Age-Related Histone Hypoacetylation | 0.52 | 0.55 | HDAC1; HDAC2 | proposed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| h-2a31d5df00 | TSPO PET Kinetic Modeling for Priming State Discrimination | 0.52 | 0.55 | TSPO | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062039-3b945972 |
| h-7a8d7379 | Piezoelectric Nanochannel BBB Disruption | 0.52 | 0.10 | CLDN5, OCLN | debated | 2026-04-02 | sda-2026-04-01-gap-008 |
| h-aging-hippo-cortex | Hippocampal-Cortical Transcriptomic Divergence Reveals Accelerated Neurodegenera | 0.52 | 0.70 | CDKN2A | active | 2026-04-24 | aging-mouse-brain-2026-04-02 |
| h-var-5cc4b6d5db | CD33-Dependent Switch Hypothesis: CD33 Antagonism Redirects SPP1 Signaling from | 0.52 | 0.34 | CD33 | proposed | 2026-04-26 | SDA-2026-04-07-gap-pubmed-20260406-062118-2cdbb0dd |
| h-var-28394c8ce5 | LRP1-Mediated Endosomal Escape Enhancement Strategy | 0.52 | 0.53 | LDLR | proposed | 2026-04-26 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-ec9e48df | NRF2 Activation to Counteract Oxidative Stress from RGS6 Deficiency | 0.52 | 0.45 | | proposed | 2026-04-18 | SDA-2026-04-17-gap-pubmed-20260410-145520-5692b02e |
| h-fa757ac897 | Membrane interfacial selectivity for lipid-anchored pathologic conformers | 0.52 | 0.52 | SNCA, HSPA8, DNAJB6 | proposed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| h-15aa6d36c0 | Metabolic Accumulation (Ammonia/Manganese) Triggers IBA1 Downregulation via NRF2 | 0.52 | 0.48 | NRF2/NFE2L2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041439-306c2cdb |
| h-var-3049fa9ae4 | Cerebrospinal NFL-Triggered Liposome Dosing Maximizes lncRNA-0021 Therapeutic Wi | 0.52 | 0.39 | CSF NFL (biomarker), lncRNA-0021, synthetic liposomes | promoted | 2026-04-20 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| h-aging-h5-regional- | Hippocampus ages transcriptionally faster than cerebellum, defining a regional v | 0.52 | 0.80 | CLU | open | 2026-04-23 | aging-mouse-brain-2026-04-02 |
| h-e0183502 | Vocal Cord Neuroplasticity Stimulation | 0.52 | 0.30 | CHR2/BDNF | debated | 2026-04-02 | sda-2026-04-01-gap-012 |
| h-SDA-2026-04-26-gap | Synergistic Timing With Acetylcholinesterase Inhibitors | 0.52 | 0.38 | MT1/MT2; AChE; CHRM1 (M1 muscarinic); BACE1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260411-090734-1be1b913 |
| h-SDA-2026-04-26-gap | Matrix Metalloproteinase-9-Mediated Claudin-5 Cleavage Drives Early Tight Juncti | 0.52 | 0.28 | MMP9 | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-001521 |
| h-65b79f09 | ApoE4-Mediated Failure of Cholesterol Efflux as Memory Maintenance Mechanism | 0.52 | 0.45 | APOE (ApoE4 isoform) → cholesterol metabolism | proposed | 2026-04-26 | SDA-2026-04-08-gap-debate-20260406-062033-ad87c3fb |
| h-05e92f66f1 | CSF p-tau217 Normalization Requires Intact Synaptic Function and BBB Integrity ( | 0.52 | 0.45 | NA - Patient stratification factor | proposed | 2026-04-25 | |
| h-test-8d254307 | EV-Mediated Epigenetic Reprogramming | 0.51 | 0.50 | EVs/miRNAs | archived | 2026-04-11 | sda-2026-04-12-ev-ad-biomarkers |
| h-929f356e | GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to Reduce Neuroinflammat | 0.51 | 0.55 | GAS6/TAM receptor complex | proposed | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-174607-708e8d91 |
| h-a3bfd2e13a | CSF p-tau217 Threshold of <0.15 pg/mL Predicts Durable Clinical Benefits After T | 0.51 | 0.42 | NA - Companion diagnostic target | proposed | 2026-04-25 | |
| hyp_test_0215075b | Test: TREM2 enhances amyloid clearance | 0.51 | 0.28 | TREM2 | proposed | 2026-04-17 | test-hypothesis-fixtures-v1 |
| h-8385e7fd | Neuroplasticity-Enhanced Learning Hypothesis | 0.51 | 0.71 | BDNF | proposed | 2026-04-12 | SDA-2026-04-04-gap-debate-20260403-222510-20260402 |
| h-aging-myelin-amylo | Myelin Breakdown-Amyloid Interaction Amplifies Cortical Aging-Neurodegeneration | 0.51 | 0.45 | MBP | active | 2026-04-24 | aging-mouse-brain-2026-04-02 |
| h-74777459 | Microbial Metabolite-Mediated α-Synuclein Disaggregation | 0.51 | 0.40 | SNCA, HSPA1A, DNMT1 | proposed | 2026-04-02 | SDA-2026-04-01-gap-20260401-225155 |
| h-var-a3cfa5bb63 | SASP-Secreted MMP-9 from Senescent Microglia Disrupts TDP-43 Nuclear Retention L | 0.51 | 0.34 | MMP9 → nuclear import machinery (KPNA1, NUP proteins, LMNA) | proposed | 2026-04-27 | SDA-2026-04-26-gap-20260425215446 |
| h-afdb1b087a | Glial Metabolic Coupling Failure in Neuronal Bioenergetic Crisis | 0.51 | 0.52 | MCT1/MCT4, lactate dehydrogenase | proposed | 2026-05-03 | SDA-2026-05-03-gap-test-20260425-224949 |
| h-fc57d8e73d | Rational design of small molecules targeting TDP-43 liquid-to-solid phase transi | 0.51 | 0.72 | TARDBP | proposed | 2026-05-01 | SDA-2026-05-01-gap-test-20260425-224949 |
| h-d1a1a391ed | Astrocyte senescence and SASP-driven neuroinflammation in ALS | 0.51 | 0.50 | CDKN2A; CDKN1A; IL6 | proposed | 2026-04-29 | SDA-2026-04-29-gap-test-20260425-224949 |
| h-62fca066b1 | Metabolic Correction via SGLT2/PDK Modulation for ALS Energy Homeostasis | 0.51 | 0.50 | SGLT2/PDK | proposed | 2026-04-28 | SDA-2026-04-28-gap-test-20260425-224949 |
| h-2b25f4433e | High baseline tau and ISR activation may lower the effective trazodone threshold | 0.51 | 0.50 | MAPT; EIF2AK3; EIF2S1; ATF4 | proposed | 2026-04-25 | |
| h-7478dba3ed | Loss of pericyte-derived pleiotrophin is a key disease-modifying consequence of | 0.51 | 0.39 | PTN | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-de5dfc4391 |
| h-f94e391387 | Tripartite Synapse Cell Type-Nonautonomous Crosstalk: Coordinated Failure | 0.51 | 0.48 | C1Q | proposed | 2026-04-22 | SDA-2026-04-02-gap-seaad-debate-v4 |
| h-848a3f33cc | Soluble GAG-Mimetic Peptides Compete with HSPG for Tau Seed Binding and Prevent | 0.51 | 0.55 | GPC1 | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-052358 |
| h-42d01f0454 | Targeted DNA Demethylation at the Klotho Locus via dCas9-TET1 Rescues Neuroprote | 0.51 | 0.62 | KL (Klotho)/dCas9-TET1 | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-060512 |
| h-591d641a01 | Primed microglia occupy a hybrid high-glycolysis and high-respiration metabolic | 0.51 | 0.48 | PDHA1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062033-839c3e2a |
| h-703a747d3b | Lamin B1 Restoration Prevents Age-Related Nuclear Lamina Compromise | 0.51 | 0.55 | LMNB1 | proposed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| h-455dbebe | Astrocyte-Specific DGAT1 Inhibition to Prevent Lipid Droplet-Induced Neuroinflam | 0.51 | 0.55 | DGAT1 | proposed | 2026-04-25 | SDA-2026-04-16-frontier-lipidomics-dcdbc360 |
| h-562d178a | Anti-CD47/SIRPα Checkpoint Therapy to Enhance Phagocytic Clearance | 0.51 | 0.50 | CD47/SIRPα axis; target: CD47 on plaques/neurons | proposed | 2026-04-25 | SDA-2026-04-16-frontier-immunomics-e6f97b29 |
| h-var-690bdeddfd | TFEB-Mediated Retromer Biogenesis to Restore Endosomal-Lysosomal Trafficking in | 0.51 | 0.26 | TFEB | proposed | 2026-04-26 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-098b03f430 | Transcriptome-wide competition determines functional selectivity after direct bi | 0.51 | 0.44 | mmu-miR-6361 | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| h-15f088c56f | Blood Monocyte Epigenetic Signature as Surrogate for Microglial Priming | 0.51 | 0.42 | Epigenetic landscape (TLR4, NLRP3, IL1B regulatory regions) | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062039-3b945972 |
| h-942b276bdd | Astrocyte Reactivity Mediated by LCN2 Promotes Synaptic Loss in Alzheimer's Dise | 0.51 | 0.55 | LCN2 | proposed | 2026-04-26 | legacy-pre-pipeline-import-v1 |