| h-a3bfd2e13a | CSF p-tau217 Threshold of <0.15 pg/mL Predicts Durable Clinical Benefits After T | 0.51 | 0.42 | NA - Companion diagnostic target | proposed | 2026-04-25 | |
| hyp_test_0215075b | Test: TREM2 enhances amyloid clearance | 0.51 | 0.28 | TREM2 | proposed | 2026-04-17 | test-hypothesis-fixtures-v1 |
| h-8385e7fd | Neuroplasticity-Enhanced Learning Hypothesis | 0.51 | 0.71 | BDNF | proposed | 2026-04-12 | SDA-2026-04-04-gap-debate-20260403-222510-20260402 |
| h-aging-myelin-amylo | Myelin Breakdown-Amyloid Interaction Amplifies Cortical Aging-Neurodegeneration | 0.51 | 0.45 | MBP | active | 2026-04-24 | aging-mouse-brain-2026-04-02 |
| h-74777459 | Microbial Metabolite-Mediated α-Synuclein Disaggregation | 0.51 | 0.40 | SNCA, HSPA1A, DNMT1 | proposed | 2026-04-02 | SDA-2026-04-01-gap-20260401-225155 |
| h-var-a3cfa5bb63 | SASP-Secreted MMP-9 from Senescent Microglia Disrupts TDP-43 Nuclear Retention L | 0.51 | 0.34 | MMP9 → nuclear import machinery (KPNA1, NUP proteins, LMNA) | proposed | 2026-04-27 | SDA-2026-04-26-gap-20260425215446 |
| h-d1a1a391ed | Astrocyte senescence and SASP-driven neuroinflammation in ALS | 0.51 | 0.50 | CDKN2A; CDKN1A; IL6 | proposed | 2026-04-29 | SDA-2026-04-29-gap-test-20260425-224949 |
| h-62fca066b1 | Metabolic Correction via SGLT2/PDK Modulation for ALS Energy Homeostasis | 0.51 | 0.50 | SGLT2/PDK | proposed | 2026-04-29 | SDA-2026-04-28-gap-test-20260425-224949 |
| h-2b25f4433e | High baseline tau and ISR activation may lower the effective trazodone threshold | 0.51 | 0.50 | MAPT; EIF2AK3; EIF2S1; ATF4 | proposed | 2026-04-26 | |
| h-7478dba3ed | Loss of pericyte-derived pleiotrophin is a key disease-modifying consequence of | 0.51 | 0.39 | PTN | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-de5dfc4391 |
| h-f94e391387 | Tripartite Synapse Cell Type-Nonautonomous Crosstalk: Coordinated Failure | 0.51 | 0.48 | C1Q | proposed | 2026-04-22 | SDA-2026-04-02-gap-seaad-debate-v4 |
| h-848a3f33cc | Soluble GAG-Mimetic Peptides Compete with HSPG for Tau Seed Binding and Prevent | 0.51 | 0.55 | GPC1 | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-052358 |
| h-42d01f0454 | Targeted DNA Demethylation at the Klotho Locus via dCas9-TET1 Rescues Neuroprote | 0.51 | 0.62 | KL (Klotho)/dCas9-TET1 | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-060512 |
| h-591d641a01 | Primed microglia occupy a hybrid high-glycolysis and high-respiration metabolic | 0.51 | 0.48 | PDHA1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062033-839c3e2a |
| h-703a747d3b | Lamin B1 Restoration Prevents Age-Related Nuclear Lamina Compromise | 0.51 | 0.55 | LMNB1 | proposed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| h-455dbebe | Astrocyte-Specific DGAT1 Inhibition to Prevent Lipid Droplet-Induced Neuroinflam | 0.51 | 0.55 | DGAT1 | proposed | 2026-04-26 | SDA-2026-04-16-frontier-lipidomics-dcdbc360 |
| h-562d178a | Anti-CD47/SIRPα Checkpoint Therapy to Enhance Phagocytic Clearance | 0.51 | 0.50 | CD47/SIRPα axis; target: CD47 on plaques/neurons | proposed | 2026-04-26 | SDA-2026-04-16-frontier-immunomics-e6f97b29 |
| h-var-690bdeddfd | TFEB-Mediated Retromer Biogenesis to Restore Endosomal-Lysosomal Trafficking in | 0.51 | 0.26 | TFEB | proposed | 2026-04-27 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-098b03f430 | Transcriptome-wide competition determines functional selectivity after direct bi | 0.51 | 0.44 | mmu-miR-6361 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| h-15f088c56f | Blood Monocyte Epigenetic Signature as Surrogate for Microglial Priming | 0.51 | 0.42 | Epigenetic landscape (TLR4, NLRP3, IL1B regulatory regions) | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062039-3b945972 |
| h-942b276bdd | Astrocyte Reactivity Mediated by LCN2 Promotes Synaptic Loss in Alzheimer's Dise | 0.51 | 0.55 | LCN2 | proposed | 2026-04-26 | legacy-pre-pipeline-import-v1 |
| h-aging-opc-elf2 | ELF2-Mediated OPC Epigenetic Drift Drives Region-Dependent Myelin Dysfunction | 0.51 | 0.55 | ELF2 | active | 2026-04-24 | aging-mouse-brain-2026-04-02 |
| h-2f032e79df | Circulating IBA1 Protein Absorption/Interference with Detection | 0.51 | 0.42 | AIF1/IBA1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041439-306c2cdb |
| h-4b6e8204bf | Epigenetic Dysregulation of APOE Microglial Expression | 0.51 | 0.55 | APOE | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-6ca2dbc5f0 | REST-like neuronal silencing programs suppress MAPT in severe proteostatic stres | 0.51 | 0.43 | REST | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260411-083749-7d0cea3d-debate |
| h-98ddffb4cd | PKM2 nuclear translocation bridges metabolism and inflammatory transcription in | 0.51 | 0.44 | PKM2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062033-839c3e2a |
| h-ecfaa2cbb2 | Parthenolide perturbs adenosine transport or metabolism upstream of ADORA2A | 0.51 | 0.46 | ADORA2A | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-193037-1dc5e03a-debate |
| h-315367de | TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Function by Suppressing IL- | 0.51 | 0.42 | TYRO3 | proposed | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-174607-708e8d91 |
| h-ea51415536 | TFUS-Gamma Entrainment Synergizes with Anti-Amyloid Immunotherapy | 0.51 | 0.42 | P2X7 (P2RX7), FcγRIIB (FCGR2B), TREM2, mGluR5 (GRM5) | proposed | 2026-04-28 | SRB-2026-04-28-h-var-a4975bdd96 |
| h-495454ef | Synthetic Biology Approach: Designer Mitochondrial Export Systems | 0.51 | 0.20 | Synthetic fusion proteins | proposed | 2026-04-03 | SDA-2026-04-01-gap-20260401231108 |
| h-var-a7d6fbbb00 | TREM2-Mediated Spatial Redistribution of Complement Regulators Controls Synaptic | 0.50 | 0.33 | TREM2 | proposed | 2026-04-27 | SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9 |
| h-28d5b559 | Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neuroprotection | 0.50 | 0.50 | TFAM, MT-CO1 | proposed | 2026-04-12 | SDA-2026-04-04-SDA-2026-04-04-gap-debate-20260403-222618-c69 |
| SDA-2026-04-02-gap-t | Trans-Synaptic Adhesion Molecule Modulation | 0.50 | 0.33 | NLGN1 | archived | 2026-04-17 | SDA-2026-04-04-gap-tau-prop-20260402003221 |
| h-3b463f9c27 | Stage-Dependent Biphasic SPP1 Targeting: Early Enhancement Followed by Late Inhi | 0.50 | 0.45 | SPP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062118-2cdbb0dd |
| h-177d9cb05108 | Disease-Elevated CHI3L1/CHIT1 Chitinases Are Biomarkers and Partial Compensators | 0.50 | 0.73 | CHI3L1 (YKL-40), CHIT1, CHI3L2 / MMP-2 / TREM2 / MerTK | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260425215446 |
| h-3294f3a8 | CCR2+ Monocyte Depletion as Restoration of CNS Immune Privilege | 0.50 | 0.45 | CCL2/CCR2 axis; specifically CCR2+ monocytes | proposed | 2026-04-26 | SDA-2026-04-16-frontier-immunomics-e6f97b29 |
| h-bc10d5f3fd | Downstream Pathway Selective Modulation: ITGAX (αXβ2) Integrin Blockade | 0.50 | 0.50 | ITGAX (CD11c) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062118-2cdbb0dd |
| cff6d01d-d3d4-4a09-9 | Test hypothesis 1 | 0.50 | 0.32 | | proposed | 2026-04-27 | |
| e27e9fa0-7915-4b55-a | Test hypothesis 1 | 0.50 | 0.32 | | proposed | 2026-04-27 | |
| f2cde881-ad97-4c0c-8 | Test hypothesis 1 | 0.50 | 0.32 | | proposed | 2026-04-27 | |
| 489b30cf-2825-4058-a | Test hypothesis 1 | 0.50 | 0.32 | | proposed | 2026-04-27 | |
| h-var-95b0f9a6bc-pro | Glymphatic-Mediated Tau Clearance Dysfunction (Proteomics DE) | 0.50 | 0.52 | MAPT | proposed | 2026-04-27 | |
| h-11ba42d0-cel | APOE4-Specific Lipidation Enhancement Therapy (Cell-Cell Communication) | 0.50 | 0.39 | APOE | proposed | 2026-04-27 | SDA-BIOMNI-CELL_CEL-a7eed9c5 |
| h-89f2d5ab82 | Mitochondrial-Targeted PINK1/Parkin Pathway Activation for Neuroprotection | 0.50 | 0.68 | PINK1/PRKN | proposed | 2026-04-26 | test-hypothesis-fixtures-v1 |
| h-f3eff15058ab | MAP6-mediated microtubule stabilization as therapeutic target | 0.50 | 0.50 | MAP6 | proposed | 2026-04-26 | paper-34025352 |
| h-0ad79cf81a | Astrocyte-Neuron Lactate Shuttle (H6): Metabolic Coupling Restoration | 0.50 | 0.52 | SLC16A1 (MCT1 monocarboxylate transporter 1) | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-180918-962b1ada-debate |
| h-cf07e38ecd | Synergistic reduction of amyloid-tau interaction through secondary effects | 0.50 | 0.65 | BACE1/GSK3β | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-150544-e3a2eab9-debate |
| h-c573394de8 | APOE4 astrocytes fail to supply sufficient cholesterol to parvalbumin interneuro | 0.50 | 0.48 | LDLR, LRP8 (ApoER2), APOE | proposed | 2026-04-22 | SDA-2026-04-04-gap-apoe4-lipid-metabolism |
| h-1487c2bad4 | Early Postnatal TGF-beta Signaling Establishes Lifelong Regional Vulnerability T | 0.50 | 0.55 | TGFBR1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-ec89b1e4 |
| h-929aef3ac1 | Modulation of G3BP1 Intrinsically Disordered Region Solvation Free Energy | 0.50 | 0.52 | G3BP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041423-2d1db50c |