| h-var-071a199828 | TFEB Activation to Restore Lysosomal Function in Parkinson's Disease Alpha-Synuc | 0.38 | 0.26 | TFEB | proposed | 2026-04-27 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-var-c622bde475 | TFEB Family-Wide Activation to Restore Lysosomal Networks in Early Alzheimer's S | 0.38 | 0.26 | TFEB/TFE3/TFE4 family | proposed | 2026-04-27 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-var-cddf0dc2a9 | TFEB Activation to Restore Lysosomal Biogenesis in Parkinson's Disease Dopaminer | 0.38 | 0.26 | TFEB | proposed | 2026-04-27 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-var-d7dd33d5a3 | TFEB-mediated Autophagy Enhancement to Clear Protein Aggregates in Neurodegenera | 0.38 | 0.26 | TFEB | proposed | 2026-04-27 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-var-5bc88e4dd8 | TFEB Family Multi-Target Activation for Synaptic Lysosomal Restoration in Alzhei | 0.38 | 0.26 | TFEB/TFE3/TFE4 | proposed | 2026-04-27 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-var-f988ec2954 | TFEB-Mediated Autophagosome-Lysosome Fusion Enhancement in Aged Neuronal Synapse | 0.38 | 0.26 | TFEB | proposed | 2026-04-27 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-var-6ef1f43d79 | Chaperone-Autophagy Coupling Prevents Aggregate Persistence by Directing Seeds t | 0.38 | 0.34 | STUB1 (CHIP), autophagy pathway components (LC3, p62/SQSTM1) | proposed | 2026-04-27 | SDA-2026-04-06-gap-debate-20260406-062052-28cbc764 |
| h-var-ccdfa817f0 | Kinetic Threshold Model of Chaperone-CHIP Coupling: ATP Cycle Velocity Determine | 0.38 | 0.33 | STUB1 | proposed | 2026-04-27 | SDA-2026-04-06-gap-debate-20260406-062052-28cbc764 |
| h-var-595760cb30 | Autophagy-Lysosomal Clearance Capacity Determines Therapeutic Window—Substrate C | 0.38 | 0.33 | LC3-II/p62 cargo recognition complex | proposed | 2026-04-27 | SDA-2026-04-06-gap-debate-20260406-062052-28cbc764 |
| h-var-139df78e35 | CHIP-mediated K63-linked ubiquitination promotes autophagosomal sequestration of | 0.38 | 0.34 | STUB1 (CHIP), HSPA8, SQSTM1, UBE2N, BECN1, ATG7 | proposed | 2026-04-27 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| h-var-09485f89f9 | CHIP-mediated K63-linked ubiquitination redirects oligomeric pathologic conforme | 0.38 | 0.34 | STUB1 (CHIP), HSPA8, VCP, SQSTM1, UBE2N | proposed | 2026-04-27 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| h-var-ef13aea74f | Exposed amyloidogenic segments trigger CHIP-mediated oligomer-selective ubiquiti | 0.38 | 0.35 | STUB1 | proposed | 2026-04-27 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| h-var-5d67613102 | HSP70 recognition of exposed β-sheet segments triggers CHIP-mediated selective d | 0.38 | 0.35 | STUB1 | proposed | 2026-04-27 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| h-var-0648992d66 | Amyloidogenic segments undergo conformational templating by HSP90-HSP70 heteroco | 0.38 | 0.35 | HSP90AA1, HSPA8, HSPA1A, DNAJB6, DNAJB2, STIP1 | proposed | 2026-04-27 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| h-var-c027b2a8ee | HSP90-CDC37 complex recognizes exposed hydrophobic clusters as amyloidogenic dan | 0.38 | 0.35 | HSP90AA1, HSP90AB1, CDC37 | proposed | 2026-04-27 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| h-var-9d9dc08d4d | GluN2B-Mediated Microglial Activation and Tau Phagocytosis | 0.38 | 0.59 | GRIN2B | proposed | 2026-04-27 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-f08f96e530 | TREM2-Regulated Astrocytic Calcium Dynamics Control Glymphatic Tau Clearance | 0.38 | 0.62 | TREM2 | proposed | 2026-04-27 | SDA-2026-04-26-trem2-showcase |
| h-var-05d273b7f3 | RAGE-Mediated Transcytotic Pump Enhancement Strategy | 0.38 | 0.53 | LDLR | proposed | 2026-04-27 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-var-fcc307041a | TREM2-Mediated Microglial Dysfunction Impairs Synaptic Tau Propagation Blockade | 0.38 | 0.62 | TREM2 | proposed | 2026-04-27 | SDA-2026-04-26-trem2-showcase |
| h-var-358e882d05 | LDLR-Primed LRP1 Transcytosis with Endosomal Liberation Strategy | 0.38 | 0.53 | LDLR | proposed | 2026-04-27 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-var-bb6677aa73 | LDLR-Mediated Reverse Cholesterol Transport Modulation for CNS Drug Delivery | 0.38 | 0.53 | LDLR | proposed | 2026-04-27 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-var-76490d8b19 | LDLR-Mediated Neuroinflammation Modulation Strategy | 0.38 | 0.53 | LDLR | proposed | 2026-04-27 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-var-51f61f705d | LDLR-Primed LRP1 Transcytosis with pH-Activated Endosomal Escape | 0.38 | 0.53 | LDLR | proposed | 2026-04-27 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-var-a4a4a4b781 | LDLR-Mediated Lipid Carrier Neurotherapeutic Delivery | 0.38 | 0.53 | LDLR | proposed | 2026-04-27 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-var-978902877f | cGAS Inhibitors for ALS Therapeutics: Targeting Upstream mtDNA Recognition | 0.38 | 0.33 | MB21D1 (cGAS) | proposed | 2026-04-27 | SDA-2026-04-07-gap-pubmed-20260406-062141-fc60e018 |
| h-var-09a731430d | Mitophagy Enhancement Blocks STING-Mediated Neuroinflammation in ALS | 0.38 | 0.55 | PINK1 | promoted | 2026-04-27 | SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402 |
| h-var-12da54be2c | PINK1/PARK2 Mitophagy Enhancement for Microglial Polarization | 0.38 | 0.55 | PINK1 | promoted | 2026-04-27 | SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402 |
| h-var-fb974d4b65 | TREM2-Mediated Oligodendrocyte Metabolic Support in White Matter Neurodegenerati | 0.38 | 0.71 | TREM2 | proposed | 2026-04-27 | SDA-2026-04-26-trem2-showcase |
| h-var-f1f624c111 | TREM2-Mediated Senescent Microglial Reprogramming of Astrocyte Networks | 0.38 | 0.71 | TREM2 | promoted | 2026-04-27 | SDA-BIOMNI-SPATIAL_-c2b61633 |
| h-var-47bbbf5711 | TREM2-Dependent Astrocyte-Microglia Cross-talk in Neuroinflammation | 0.38 | 0.71 | TREM2 | promoted | 2026-04-27 | SDA-BIOMNI-SPATIAL_-c2b61633 |
| h-var-288308c7dc | Theta-Alpha Oscillation Entrainment Enhances lncRNA-9969-Mediated Mitochondrial | 0.38 | 0.34 | SST, CREB1, lncRNA-9969, PGC1A, TFAM | proposed | 2026-04-27 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| h-var-08fd0f5a54 | CREB1-Induced lncRNA-9969 Selectively Binds miR-6361 Through Dual Seed-Structure | 0.38 | 0.34 | lncRNA-9969 | proposed | 2026-04-27 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| h-var-39780e4efa | Competitive endogenous RNA network modulates mmu-miR-6361 availability through l | 0.38 | 0.34 | lncRNA-0021 | proposed | 2026-04-27 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| h-var-4bd74ce5ce | Enhancement of Astrocytic Ketone Body Production via HMGCS2 Overexpression | 0.38 | 0.26 | HMGCS2 | proposed | 2026-04-27 | SDA-2026-04-16-frontier-metabolomics-f03b09d9 |
| h-var-ffacbbd9f1 | NAD+-Dependent Upregulation of MCT1 Expression to Restore Neuronal Ketone Metabo | 0.38 | 0.26 | SLC16A1 (MCT1) | proposed | 2026-04-27 | SDA-2026-04-16-frontier-metabolomics-f03b09d9 |
| h-var-595ee613e2 | LXRα-Selective Agonism to Enhance Hepatic APOE Secretion and Peripheral Choleste | 0.38 | 0.34 | LXRα (NR1H3) | proposed | 2026-04-27 | SDA-2026-04-16-frontier-lipidomics-dcdbc360 |
| h-var-de3e3c7494 | CD38 Inhibition to Preserve NAD+ Pools and Prevent PARP1-Mediated Metabolic Dysf | 0.38 | 0.26 | CD38, PARP1, SIRT1/3 | proposed | 2026-04-27 | SDA-2026-04-16-frontier-metabolomics-f03b09d9 |
| h-var-12f509effb | LXRβ-Selective Agonism Enhances CYP2J2-Mediated DHA Epoxide Generation to Restor | 0.38 | 0.34 | NR1H2 (LXRβ) | proposed | 2026-04-27 | SDA-2026-04-16-frontier-lipidomics-dcdbc360 |
| h-var-106f5023b1 | CCL2 Gradient Disruption via Astrocytic CXCL12 Upregulation for CNS Immune Privi | 0.38 | 0.26 | CXCL12 | proposed | 2026-04-27 | SDA-2026-04-16-frontier-immunomics-e6f97b29 |
| h-var-cb5e57de02 | CYP2J2-Derived DHA Epoxides Modulate Microglial M2 Polarization to Reduce Neuroi | 0.38 | 0.34 | CYP2J2/microglial PPAR-γ | proposed | 2026-04-27 | SDA-2026-04-16-frontier-lipidomics-dcdbc360 |
| h-var-b046808f73 | CRP-Mediated CCR2+ Monocyte Recruitment Drives Microglial IL-1β Amplification an | 0.38 | 0.26 | CCR2, TLR4, IL1B | proposed | 2026-04-27 | SDA-2026-04-16-frontier-immunomics-e6f97b29 |
| h-var-b066cde5b5 | Circulating hs-CRP as Disease-Modifying Target via Astrocytic NLRP3 Inflammasome | 0.38 | 0.26 | CRP → NLRP3 → IL-1β/IL-18 | proposed | 2026-04-27 | SDA-2026-04-16-frontier-immunomics-e6f97b29 |
| h-var-f765378ad3 | Lentiviral-Mediated Astrocytic IGFBPL1 Expression via GFAP Promoter | 0.38 | 0.26 | IGFBPL1 | proposed | 2026-04-27 | SDA-2026-04-06-gap-debate-20260406-062045-6addd0cf |
| h-var-99baab6d43 | FUS-Enhanced AAV-PHP.eB Delivery for Microglial IGFBPL1 Expression | 0.38 | 0.26 | IGFBPL1 | proposed | 2026-04-27 | SDA-2026-04-06-gap-debate-20260406-062045-6addd0cf |
| h-var-66f8d10cd1 | Ultrasound-Responsive Liposomal Nanocarriers with Thermosensitive Release | 0.38 | 0.26 | IGFBPL1 | proposed | 2026-04-27 | SDA-2026-04-06-gap-debate-20260406-062045-6addd0cf |
| h-var-d865aeb1ca | Microglial Phenotypic Polarization via CSF1R-Mediated Metabolic Reprogramming | 0.38 | 0.38 | CSF1R | proposed | 2026-04-27 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-var-d0bf0fed1b | CCR2-Mediated Microglial Replacement Drives mTOR-HIF1α Metabolic Reprogramming i | 0.38 | 0.34 | CCR2 | proposed | 2026-04-27 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-var-5fc1767ef7 | Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis | 0.38 | 0.34 | PRKAA1/PPARGC1A | proposed | 2026-04-27 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-var-2a13bbdf73 | Microglia-Mediated Synaptic Pruning Modulation to Optimize Functional Connectome | 0.38 | 0.26 | CX3CR1 | proposed | 2026-04-27 | SDA-2026-04-16-frontier-connectomics-84acb35a |
| h-var-d171eed9a7 | TREM2-Mediated Microglial Regulation of Oligodendrocyte Precursor Cell Recruitme | 0.38 | 0.34 | TREM2 | proposed | 2026-04-27 | SDA-2026-04-16-frontier-connectomics-84acb35a |