| h-dfb6bf5d59 | TGF-β1-SMAD Signaling Dysregulation | 0.38 | 0.30 | TGFB1; TGFBR2; SMAD2/3 | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-170057-a2f72fd8-debate |
| h-0a83fc12c7 | LRP1-Autophagy BBB Permeabilization for Antibody Transport | 0.38 | 0.42 | LRP1; ATG7; OPTN (autophagy pathway); CLDN5 (tight junctions | proposed | 2026-04-22 | SDA-2026-04-02-gap-bbb-antibody-transport |
| h-var-fd886d16bb | TBK1 Loss Drives MMP-9-Mediated TDP-43 Fragmentation Through Senescent Microglia | 0.38 | 0.34 | TBK1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260425215446 |
| h-var-6adce8290a | Real-time optogenetic activation of CA3 PV interneurons to restore theta-gamma c | 0.38 | 0.67 | PVALB | promoted | 2026-04-26 | SDA-2026-04-03-26abc5e5f9f2 |
| h-28b0cc81 | Ethnic and Metabolic Epigenetic Clock Divergence Explains Disparate AD Risk — Hi | 0.38 | 0.17 | AD, IL, TNF | active | 2026-04-25 | SDA-2026-04-25-gap-epi-clock-biomarker-20260425-222549 |
| h-490d3f2798 | Gamma Entrainment Reduces Amyloid via Perineuronal Net Modification | 0.38 | 0.32 | CaMKIIα (CAMK2A), MMP-9 (MMP9), CSPG (aggrecan, brevican) | proposed | 2026-04-28 | SRB-2026-04-28-h-var-a4975bdd96 |
| h-aging-h4-mito-hipp | Hippocampal mitochondrial dysfunction accelerates with age and drives regional A | 0.37 | 0.70 | TFAM | open | 2026-04-23 | aging-mouse-brain-2026-04-02 |
| h-e2878cf1a1 | P2RY12 activation induces cellular senescence in cerebral VSMCs, driving neurode | 0.37 | 0.32 | P2RY12 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041434-d7920f3b |
| h-e315a365 | Synaptic-Selective Autophagy Receptor Expression to Bypass Axonal Lysosome Defic | 0.37 | 0.40 | SQSTM1 (p62/sequestosome 1) | proposed | 2026-04-25 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-fe0badfd2d | Patients with OSA or high nocturnal arousal burden may require higher trazodone | 0.37 | 0.21 | HTR2A; HRH1 | proposed | 2026-04-25 | |
| h-527d32c9 | GrimAge Acceleration as a Cell-Type-Resolved CSF Biomarker Panel for Early AD St | 0.37 | 0.15 | CSF, DNA, MCI, GDF, PAI | active | 2026-04-25 | SDA-2026-04-25-gap-epi-clock-biomarker-20260425-222549 |
| h-var-5f0a621982 | Site-Specific TREM2 Fragment Analysis Within Multi-Analyte CSF Panel for Microgl | 0.37 | 0.35 | TREM2 | proposed | 2026-04-26 | SDA-2026-04-06-gap-debate-20260406-062039-3b945972 |
| h-SDA-2026-04-26-gap | Axonal Integrity Recovery Following Amyloid Clearance Drives CSF p-tau217 Normal | 0.37 | 0.33 | MAPT, RAB GTPases | proposed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260417-033134-20519caa |
| h-8eb6be5e | Mitochondrial-to-Nuclear Epigenetic Communication via N-formylmethionine | 0.36 | 0.35 | Mitochondrial-to-Nuclear Epigenetic Communication | proposed | 2026-04-25 | SDA-2026-04-19-gap-epigenetic-comparative-ad-pd-als |
| h-d594176e58 | CK2-mediated HSP90α phosphorylation switches client discrimination toward diseas | 0.36 | 0.40 | HSP90AA1, CSNK2A1, CSNK2A2 | proposed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| h-8b4dd326 | Ferroptosis as Epiphenomenon of Terminal Collapse | 0.36 | 0.45 | | proposed | 2026-04-18 | SDA-2026-04-18-gap-debate-20260417-032952-48bdcbea |
| h-aging-h1-neuroinfl | Age-related neuroinflammation mimics early Alzheimer's disease pathology | 0.36 | 0.78 | GFAP | open | 2026-04-23 | aging-mouse-brain-2026-04-02 |
| h-gap-5c6cec3e-m1 | tight-junction remodeling is the actionable driver in: Blood-brain barrier perme | 0.36 | 0.74 | tight-junction remodeling | active | 2026-04-26 | SDA-2026-04-26-gap-20260426-001501 |
| h-9adb5c9e | Gap Junction Hemichannel Modulation for Controlled Mitochondrial Exchange | 0.36 | 0.40 | PANX1 | archived | 2026-04-02 | SDA-2026-04-01-gap-20260401231108 |
| h-var-37240814a5 | SASP-Secreted MMP-9 from Senescent Microglia Disrupts Nuclear-Cytoplasmic Transp | 0.36 | 0.34 | MMP9 → NUP62/NUP88 → TARDBP mislocalization | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260425215446 |
| h-65b13bc5c9 | Microglial IKKβ Inhibition to Block NF-κB-Mediated Inflammation | 0.36 | 0.32 | IKKβ (CHUK) | proposed | 2026-05-04 | SDA-2026-05-04-gap-test-20260425-224949 |
| h-54560505fc | Direct APOE4-TDP-43 Protein-Protein Interaction Promoting Aggregation Seeding | 0.36 | 0.22 | APOE, TARDBP | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062202-c8c5a9a1 |
| h-674768dee1 | Reticulocalbin-2 bridges calcineurin to lysosomal membranes for Ca2+-dependent a | 0.36 | 0.35 | RCN2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062150-387cb0ba |
| h-var-3c2caa6863 | AAV-PHP.eB-Mediated Astrocytic IGFBPL1 Expression | 0.36 | 0.26 | IGFBPL1 | proposed | 2026-04-26 | SDA-2026-04-06-gap-debate-20260406-062045-6addd0cf |
| h-var-17eb718c9e | hs-CRP-Driven CCR2+ Monocyte Recruitment Disrupts CNS Immune Privilege via IL-1β | 0.36 | 0.26 | CCR2 | proposed | 2026-04-26 | SDA-2026-04-16-frontier-immunomics-e6f97b29 |
| h-gap-5c6cec3e-m3 | endothelial transcytosis defines the therapeutic window for: Blood-brain barrier | 0.36 | 0.66 | endothelial transcytosis | active | 2026-04-26 | SDA-2026-04-26-gap-20260426-001501 |
| h-var-5c12304fe5 | Astrocyte-Mediated Synaptic Pruning to Optimize Functional Connectome Efficiency | 0.35 | 0.26 | C1q | proposed | 2026-04-26 | SDA-2026-04-16-frontier-connectomics-84acb35a |
| h-var-03e3bc253a | Astrocytic MEGF10 Upregulation for Selective Synaptic Engulfment Control | 0.35 | 0.34 | MEGF10 | proposed | 2026-04-26 | SDA-2026-04-16-frontier-connectomics-84acb35a |
| h-9553243b | Network-Directed Anti-Amyloid Immunotherapy via Transcranial Focused Ultrasound | 0.35 | 0.35 | Network-Directed Anti-Amyloid Immunotherapy | proposed | 2026-04-25 | SDA-2026-04-16-frontier-connectomics-84acb35a |
| h-var-5a3995adf3 | Astroglial Gating of Microglial Ontogeny Switch | 0.35 | 0.38 | P2RY12 | proposed | 2026-04-26 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-var-7ae3e36938 | CCR2-Mediated Microglial Replacement Drives mTOR-HIF1α Metabolic Reprogramming i | 0.35 | 0.34 | CCR2 | proposed | 2026-04-26 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-var-07e5133dc3 | Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis | 0.35 | 0.34 | PRKAA1/PPARGC1A | proposed | 2026-04-26 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| h-c976c89516 | Astrocyte-Neuron Lactate Shuttle via SST-Mediated Metabolic Coupling (Deprioriti | 0.35 | 0.35 | MCT1, MCT4 (astrocytic lactate transporters); Pannexin-1; KA | proposed | 2026-04-28 | SRB-2026-04-28-h-var-b7e4505525 |
| h-d3412634 | TET Enzyme Enhancement to Prevent Aberrant DNA Methylation | 0.35 | 0.35 | TET1/TET2/TET3 enzymes | proposed | 2026-04-25 | SDA-2026-04-16-gap-epigenetic-adpdals |
| h-beb59dfd | Circadian Rhythm Amplification to Restore Network Oscillation Synchronization | 0.35 | 0.35 | Circadian Rhythm Amplification | proposed | 2026-04-25 | SDA-2026-04-16-frontier-connectomics-84acb35a |
| h-b35547d2 | D2 Autoreceptor Partial Agonism as Compensatory Therapy for RGS6 Deficiency | 0.35 | 0.20 | | proposed | 2026-04-18 | SDA-2026-04-17-gap-pubmed-20260410-145520-5692b02e |
| h-7f0f1ffd | Autophagy-Epigenetic Feedback Loop Creates a Compounding Biomarker Signal — Auto | 0.35 | 0.18 | AD, ROS, BECN1, ATG5, ATG7 | active | 2026-04-25 | SDA-2026-04-25-gap-epi-clock-biomarker-20260425-222549 |
| h-feb25cb4 | STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine Memory | 0.35 | 0.25 | IL-6/STAT3/BRD4 axis; target: microglial STAT3 phosphorylati | proposed | 2026-04-25 | SDA-2026-04-16-frontier-immunomics-e6f97b29 |
| h-4a4a2713 | Mitochondrial Pyruvate Carrier Inhibition to Force Metabolic Reprogramming Towar | 0.35 | 0.30 | MPC1/MPC2 | proposed | 2026-04-25 | SDA-2026-04-16-frontier-metabolomics-f03b09d9 |
| h-gap-5c6cec3e-m2 | plasma GFAP separates causal from compensatory states in: Blood-brain barrier pe | 0.35 | 0.69 | plasma GFAP | active | 2026-04-26 | SDA-2026-04-26-gap-20260426-001501 |
| h-gap-2f2e5b80-m2 | plasma LPS-binding protein separates causal from compensatory states in: How doe | 0.35 | 0.69 | plasma LPS-binding protein | active | 2026-04-26 | SDA-2026-04-26-gap-20260425-224724 |
| h-gap-456a357b-m3 | protective chromatin remodeling defines the therapeutic window for: Are DNA meth | 0.35 | 0.66 | protective chromatin remodeling | active | 2026-04-26 | SDA-2026-04-26-gap-debate-20260410-111542-7f40fe3e |
| h-gap-92152803-m1 | ubiquitylation-dependent turnover is the actionable driver in: How do ALS-linked | 0.34 | 0.74 | ubiquitylation-dependent turnover | active | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-181402-259766ab |
| h-gap-e7852b55-m1 | age-linked CpG drift is the actionable driver in: Are age-related DNA methylatio | 0.34 | 0.74 | age-linked CpG drift | active | 2026-04-26 | SDA-2026-04-26-gap-debate-20260410-112902-5b3fc173 |
| h-gap-456a357b-m1 | age-linked CpG drift is the actionable driver in: Are DNA methylation changes in | 0.34 | 0.74 | age-linked CpG drift | active | 2026-04-26 | SDA-2026-04-26-gap-debate-20260410-111542-7f40fe3e |
| h-ccefee49 | SIRT3 Mitochondrial Activation to Counter Hub-Specific Energetic Vulnerability | 0.34 | 0.30 | SIRT3 Mitochondrial | proposed | 2026-04-25 | SDA-2026-04-16-frontier-connectomics-84acb35a |
| h-59d95760 | Epigenetic Age Acceleration Moderates the Amyloid-to-Tau Conversion Cascade — A | 0.34 | 0.17 | MAPT | active | 2026-04-25 | SDA-2026-04-25-gap-epi-clock-biomarker-20260425-222549 |
| h-gap-2f2e5b80-m1 | TLR4 priming is the actionable driver in: How does gut microbiome dysbiosis cont | 0.34 | 0.74 | TLR4 priming | active | 2026-04-26 | SDA-2026-04-26-gap-20260425-224724 |
| h-gap-456a357b-m2 | ATAC-seq accessibility separates causal from compensatory states in: Are DNA met | 0.34 | 0.69 | ATAC-seq accessibility | active | 2026-04-26 | SDA-2026-04-26-gap-debate-20260410-111542-7f40fe3e |
| h-74cfd51e | Phosphatidylserine Decarboxylase (PISD) Restoration to Correct Mitochondrial Mem | 0.34 | 0.40 | PISD | proposed | 2026-04-25 | SDA-2026-04-16-frontier-lipidomics-dcdbc360 |