| h-var-45de48a8ff | Astrocytic TREM2-Like Receptor Modulation of Synaptic Strengthening Pathways | 0.38 | 0.34 | TREML2 | proposed | 2026-04-27 | SDA-2026-04-16-frontier-connectomics-84acb35a |
| h-var-4ae5ef95fa | Plasma TREM2 Ectodomain Glycosylation Patterns as Microglial Senescence Biomarke | 0.38 | 0.27 | TREM2/ST6GAL1/MGAT5 | proposed | 2026-04-27 | SDA-2026-04-06-gap-debate-20260406-062039-3b945972 |
| h-var-03da47e875 | CSF TREM2 Fragment Ratio Integrated with Neuroinflammatory Cascade Markers | 0.38 | 0.35 | TREM2 | proposed | 2026-04-27 | SDA-2026-04-06-gap-debate-20260406-062039-3b945972 |
| h-var-92ba62855a | Dynamic Blood-Based Exosome Panel for Real-Time Neuroinflammatory State Monitori | 0.38 | 0.35 | CHI3L1/TREM2/NRGN | proposed | 2026-04-27 | SDA-2026-04-06-gap-debate-20260406-062039-3b945972 |
| h-var-7586582905 | Optogenetic restoration of SST interneuron-mediated dendritic inhibition to resc | 0.38 | 0.67 | SST | promoted | 2026-04-27 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-9c631a92e3 | Closed-loop transcranial focused ultrasound with adaptive API-guided targeting t | 0.38 | 0.18 | PVALB | archived | 2026-04-27 | SDA-BIOMNI-SURVIVAL-3e217f4d |
| h-var-f19c7ae9e4 | Mitochondrial Dysfunction-Mediated Neurodegeneration in Alzheimer's Disease | 0.38 | 0.22 | TFAM | archived | 2026-04-27 | SDA-BIOMNI-SURVIVAL-3e217f4d |
| h-ae2e26d8a3 | APOE4-driven loss of neuronal PI(4,5)P2 bridges ganglioside-mediated amyloid nuc | 0.38 | 0.72 | APOE | proposed | 2026-04-27 | SDA-2026-04-04-frontier-lipidomics-dcdbc360 |
| h-db6058d23e | Glucosylceramide-mediated feedback loop drives GBA-synuclein pathology | 0.38 | 0.72 | GBA1 | proposed | 2026-04-27 | gba-pd |
| h-29e62b7a81 | Gut dysbiosis-driven monocyte reprogramming toward NETotic phenotype accelerates | 0.38 | 0.72 | MMP9 | proposed | 2026-04-27 | SDA-2026-04-04-frontier-immunomics-e6f97b29 |
| h-f210a4000e | Gut butyrate deficiency impairs microglial amyloid clearance via HDAC2-mediated | 0.38 | 0.68 | HDAC2 | proposed | 2026-04-27 | gut-brain-ad |
| h-4bc00f3610 | Thalamic anterior nucleus hyperconnectivity drives early-stage functional compen | 0.38 | 0.68 | ENTPD1 | proposed | 2026-04-27 | SDA-2026-04-04-frontier-connectomics-84acb35a |
| h-a8d0be776e | Astrocyte CD38-erk Mapk signaling controls mitochondrial transfer to neurons via | 0.38 | 0.72 | CD38 | proposed | 2026-04-27 | sda-2026-04-01-gap-20260401231108 |
| h-var-b552a96894 | Chaperone-Autophagy Coupling Prevents Aggregate Persistence by Shunting Seeds to | 0.38 | 0.34 | SQSTM1 (p62) | proposed | 2026-04-26 | SDA-2026-04-06-gap-debate-20260406-062052-28cbc764 |
| h-var-9031067037 | Kinetic Threshold Model Predicts CHIP-Mediated Clearance Requirements for Preven | 0.38 | 0.33 | STUB1 | proposed | 2026-04-26 | SDA-2026-04-06-gap-debate-20260406-062052-28cbc764 |
| h-var-d636c381a4 | Lysosomal Clearance Capacity Determines Therapeutic Window—Autophagy Enhancement | 0.38 | 0.33 | ULK1 (autophagy initiation kinase) | proposed | 2026-04-26 | SDA-2026-04-06-gap-debate-20260406-062052-28cbc764 |
| h-var-82928adf4e | J-protein co-chaperone repertoire drives ATP-independent disaggregation through | 0.38 | 0.37 | DNAJB6, DNAJB2, HSPA8, HSPA1A | proposed | 2026-04-26 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| h-var-10237959a6 | Dopaminergic Ventral Tegmental-Striatal Circuit Protection | 0.38 | 0.62 | MAPT | promoted | 2026-04-26 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-470ed722ad | SULF-Mediated Protection of Cholinergic Tau Transport Pathways | 0.38 | 0.33 | SULF1/SULF2 | proposed | 2026-04-26 | SDA-2026-04-04-gap-tau-prion-spreading |
| h-var-6bba3e5e9a | Enhancing Heparan Sulfate 3-O-Sulfotransferase Activity to Competitively Block T | 0.38 | 0.33 | HS3ST3A1/HS3ST3B1 | proposed | 2026-04-26 | SDA-2026-04-04-gap-tau-prion-spreading |
| h-var-75d9ff29fc | TBK1 Inhibitors as ALS Therapeutics: Targeting Downstream STING Signaling | 0.38 | 0.33 | TBK1 | proposed | 2026-04-26 | SDA-2026-04-07-gap-pubmed-20260406-062141-fc60e018 |
| h-var-83a78c2c20 | STING-Mediated NLRP3 Inflammasome Priming in ALS Microglia | 0.38 | 0.55 | TMEM173 | promoted | 2026-04-26 | SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402 |
| h-var-9aaee4c214 | NLRP3/Autophagy Flux Enhancement in Astrocytes | 0.38 | 0.55 | TFEB | promoted | 2026-04-26 | SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402 |
| h-var-24303a8194 | Transcranial Magnetic Stimulation-Induced Nanoparticle Delivery via Neuronal Act | 0.38 | 0.34 | CACNA1C/SCN9A neuronal channels; CLDN5/ZO-1 | proposed | 2026-04-26 | SDA-2026-04-02-gap-bbb-antibody-transport |
| h-var-d1632ebb0f | Focused Ultrasound-Enhanced CYP46A1 Gene Therapy for Neurodegeneration | 0.38 | 0.61 | CYP46A1 | promoted | 2026-04-26 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| h-var-42910c6bed | CYP46A1 Inhibition Therapy for Neurodegeneration | 0.38 | 0.61 | CYP46A1 | promoted | 2026-04-26 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| h-var-80aad0dc7c | Theta-Gamma Cross-Frequency Coupling Modulates lncRNA-9969 Phase-Dependent Trans | 0.38 | 0.26 | SST, FMRP, lncRNA-9969, ULK1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| h-var-074f135782 | CREB1-Induced lncRNA-9969 Selectively Sequesters miR-6361 Through Dual Seed-Stru | 0.38 | 0.34 | lncRNA-9969, CREB1, PVALB | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| h-var-829523e5d2 | Competitive endogenous RNA mechanism enables lncRNA-0021 to modulate mmu-miR-636 | 0.38 | 0.34 | lncRNA-0021 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| h-var-c4819cffc2 | Mitochondrial DNA Release-STING Axis as Senolytic Efficacy Predictor | 0.38 | 0.38 | CGAS, STING1, MT-DNA | proposed | 2026-04-26 | SDA-2026-04-07-gap-debate-20260406-062101-724971bc |
| h-var-3edf3a7706 | miR-33 Antisense-Enhanced APOE4 Lipidation as Senolytic Timing Biomarker | 0.38 | 0.29 | miR-33, ABCA1, CDKN2A, CGAS | promoted | 2026-04-26 | SDA-2026-04-16-gap-debate-20260410-113104-a13caf2e |
| h-var-9662d2e636 | SREBF2 Direct Activator Hyper-Lipidation Strategy | 0.38 | 0.29 | SREBF2/ABCA1 | promoted | 2026-04-26 | SDA-2026-04-16-gap-debate-20260410-113104-a13caf2e |
| h-var-7b45fa04f3 | Enhancement of Astrocytic Ketone Body Production via HMGCS2 Overexpression | 0.38 | 0.26 | HMGCS2 | proposed | 2026-04-26 | SDA-2026-04-16-frontier-metabolomics-f03b09d9 |
| h-var-cbd9922117 | NAD+-Dependent Transcriptional Upregulation of MCT1 to Restore Neuronal Ketone M | 0.38 | 0.26 | SLC16A1 (MCT1) | proposed | 2026-04-26 | SDA-2026-04-16-frontier-metabolomics-f03b09d9 |
| h-var-f40275ceb0 | CD38 Inhibition to Prevent NAD+ Depletion and Restore Cellular Bioenergetics in | 0.38 | 0.26 | CD38, SIRT1/3 | proposed | 2026-04-26 | SDA-2026-04-16-frontier-metabolomics-f03b09d9 |
| h-var-5aea9e24d1 | ABCA1 Upregulation via LXRβ Agonism to Enhance Cholesterol Efflux and Prevent Ne | 0.38 | 0.34 | ABCA1 | proposed | 2026-04-26 | SDA-2026-04-16-frontier-lipidomics-dcdbc360 |
| h-var-ec13cac789 | CYP2J2-Generated DHA Epoxides Enhance LXRβ-Mediated APOE Lipidation for Synergis | 0.38 | 0.34 | CYP2J2 | proposed | 2026-04-26 | SDA-2026-04-16-frontier-lipidomics-dcdbc360 |
| h-var-135da2778f | ω-3 Docosahexaenoic Acid (DHA) Metabolism via 15-Lipoxygenase to Generate Specia | 0.38 | 0.34 | ALOX15/15-LOX | proposed | 2026-04-26 | SDA-2026-04-16-frontier-lipidomics-dcdbc360 |
| h-var-6a39b89a1c | CCR2+ Monocyte Reprogramming via IL-10 Enhancement for CNS Immune Privilege Rest | 0.38 | 0.26 | IL10/IL10R | proposed | 2026-04-26 | SDA-2026-04-16-frontier-immunomics-e6f97b29 |
| h-ab1c104108 | Convergent NF-κB enhancers across diverse priming stimuli share therapeutic vuln | 0.38 | 0.72 | BRD4 | proposed | 2026-04-26 | SDA-2026-04-08-gap-debate-20260406-062039-f02efa4b |
| h-a3167806d3 | NAD+-SIRT1-H3K9me3 restoration enables true senescence reversal, while incomplet | 0.38 | 0.72 | SIRT1 | proposed | 2026-04-26 | SDA-2026-04-08-gap-debate-20260406-062101-7751c220 |
| h-0455aa58e4 | Rare TREM2-TYROBP pathway variants complement standard PRS by identifying microg | 0.38 | 0.72 | PLCG2 | proposed | 2026-04-26 | SDA-BIOMNI-POLYGENI-b3028c7a |
| h-cc60dcd54d | H2S/butyrate imbalance drives enteric alpha-synuclein pathology via TLR4 signali | 0.38 | 0.72 | SNCA | proposed | 2026-04-26 | |
| h-bb7a863d9b | AD fine-mapping identifies causal variants in microglia-specific enhancers with | 0.38 | 0.72 | TREM2 | proposed | 2026-04-26 | SDA-BIOMNI-FINE_MAP-215bc2c6 |
| h-18cc1e72d7 | XOR+ stress-responsive astrocytes represent a novel AD-associated cell state lin | 0.38 | 0.72 | XOR | proposed | 2026-04-26 | |
| h-d37947d28f | Heparan sulfate proteoglycan binding selectivity determines misfolded protein tr | 0.38 | 0.62 | SDC3 (Syndecan-3) | proposed | 2026-04-26 | SDA-2026-04-08-gap-pubmed-20260406-062207-5a703c17 |
| h-ec2c5d6dc3 | O-GlcNAcylation at T212 competes with phosphorylation to redirect pathological t | 0.38 | 0.65 | OGT | proposed | 2026-04-26 | SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd |
| h-179cace7e1 | Projection-specific vulnerability to complement-mediated synaptic pruning drives | 0.38 | 0.68 | C1QA | proposed | 2026-04-26 | SDA-2026-04-08-gap-pubmed-20260406-062128-34a47c4e |
| h-5044496a | DNMT1 Downregulation to Correct Genome-Wide Hypomethylation | 0.38 | 0.42 | DNMT1 | proposed | 2026-04-25 | SDA-2026-04-16-gap-epigenetic-adpdals |
| h-62cdecaacc | HSP70/HSP40 Chaperone Complex Secretion | 0.38 | 0.35 | HSPA1A; DNAJB family | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-170057-a2f72fd8-debate |