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Hypotheses

2,369 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
SDA-2026-04-13-H0000[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
h-0000001[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
SDA-2024-0097[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
H000001[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
SDA-2025-0001[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
test[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
h-0001[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
astrocyte-neuron-met[Archived Hypothesis]0.300.48archived2026-04-14legacy-pre-pipeline-import-v1
exercise-bdnf-axis-p[Archived Hypothesis]0.300.49archived2026-04-14legacy-pre-pipeline-import-v1
post-acute-viral-res[Archived Hypothesis]0.300.47archived2026-04-14legacy-pre-pipeline-import-v1
wnt-beta-catenin-sig[Archived Hypothesis]0.300.45archived2026-04-14legacy-pre-pipeline-import-v1
SDA-H00001[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
alzheimer's-disease,[Archived Hypothesis]0.300.60archived2026-04-14legacy-pre-pipeline-import-v1
SDA-0001[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
proteasome-ubiquitin[Archived Hypothesis]0.300.48archived2026-04-14legacy-pre-pipeline-import-v1
viral-trigger-parkin[Archived Hypothesis]0.300.50archived2026-04-14legacy-pre-pipeline-import-v1
synaptic-vesicle-tra[Archived Hypothesis]0.300.45archived2026-04-14legacy-pre-pipeline-import-v1
HYP-000001[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
proteinopathic-proce[Archived Hypothesis]0.300.30archived2026-04-14legacy-pre-pipeline-import-v1
1[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
SDA-7a3b2c1d-4e5f-6g[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
HYP-003[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
HYP-002[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
HYP-010[Archived Hypothesis]0.300.30archived2026-04-14legacy-pre-pipeline-import-v1
HYP-100[Archived Hypothesis]0.300.30archived2026-04-14legacy-pre-pipeline-import-v1
HYP-001[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
h-56634f41[Archived Hypothesis]0.300.10archived2026-04-14legacy-pre-pipeline-import-v1
hyp-001[Archived Hypothesis]0.300.00archived2026-04-14legacy-pre-pipeline-import-v1
h-001[Archived Hypothesis]0.300.10archived2026-04-14legacy-pre-pipeline-import-v1
SDA-a0b1c2d3-e4f5-67[Archived Hypothesis]0.300.10archived2026-04-14legacy-pre-pipeline-import-v1
h-var-9151baec88[Archived Hypothesis]0.300.05archived2026-04-14legacy-pre-pipeline-import-v1
HYP-0001[Archived Hypothesis]0.300.05archived2026-04-14legacy-pre-pipeline-import-v1
h-abc[Archived Hypothesis]0.300.30archived2026-04-14legacy-pre-pipeline-import-v1
prion-vs-tau-alpha-s[Archived Hypothesis]0.300.05archived2026-04-14legacy-pre-pipeline-import-v1
h-aging-h7-prs-agingAD Polygenic Risk Score predicts transcriptomic aging acceleration in a dose-dep0.280.74active2026-04-27SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-173d8b11e8Tissue-specific interactome destabilization drives phenotype divergence in Mende0.280.68proposed2026-04-27SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522
h-c572ce9320Gamma Restoration Reduces Tau via Glymphatic Clearance0.280.22AQP4 (AQP4), CGRP (CALCA), VEGFR2 (KDR), p75NTR (NGFR), GSK3proposed2026-04-28SRB-2026-04-28-h-var-a4975bdd96
h-70867d3708P2RY12 rs2046934 polymorphism modifies neurodegeneration risk by altering cerebr0.270.20P2RY12 (rs2046934)proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041434-d7920f3b
h-b53bbd76Blood-Brain Barrier Metabolite Transporter Enhancement for Diagnostic and Therap0.270.20SLCO2A1 (OATP2A1)proposed2026-04-26SDA-2026-04-16-frontier-metabolomics-f03b09d9
h-9497c0a9Tau Propagation Blockade via Synaptic Ephrin-B2/ephrin-B Signaling Modulation0.270.20Tau Propagation Blockadeproposed2026-04-26SDA-2026-04-16-frontier-connectomics-84acb35a
h-11ba42d0[Archived Hypothesis]0.260.00archived2026-04-17
h-SDA-2026-04-26-gapP-tau217 Isoform Shift Indicates Mechanistic Transition Point for Cessation Elig0.240.33MAPT (PTM-modified conformers)proposed2026-04-26SDA-2026-04-26-gap-debate-20260417-033134-20519caa
h-88312042PDE10A Inhibition to Bypass RGS6 Deficiency via cAMP Pathway Normalization0.220.15proposed2026-04-18SDA-2026-04-17-gap-pubmed-20260410-145520-5692b02e
h-b2b732cd07RGS6 isoform switching or small-molecule RGS6 activation as disease-modifying th0.220.08RGS6proposed2026-04-26SDA-2026-04-26-gap-pubmed-20260410-145520-5692b02e-debate
h-b63c1b4fC1q-Alectinib Complexation Facilitates Brain Penetration via Receptor-Mediated T0.160.50C1Qproposed2026-04-18SDA-2026-04-17-gap-debate-20260417-033037-c43d12c2
h-518f3f28Direct C1q Binding Enables FcγR-Independent Complement Activation on Tumor Cells0.150.50C1Qproposed2026-04-18SDA-2026-04-17-gap-debate-20260417-033037-c43d12c2
h-cf4ff89cHuman Serum Albumin-Mediated Displacement Creates False-Positive C1q Binding Sig0.130.50C1Qproposed2026-04-18SDA-2026-04-17-gap-debate-20260417-033037-c43d12c2
h-47441cb2C1q Binding Reflects Broader Kinase Inhibitor Promiscuity Rather Than Specific C0.120.50C1Qproposed2026-04-18SDA-2026-04-17-gap-debate-20260417-033037-c43d12c2
h-463544b1Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rather Than Circulating0.120.50C1Qproposed2026-04-18SDA-2026-04-17-gap-debate-20260417-033037-c43d12c2
h-d6ae0140C1q Binding Analysis Across ALK Inhibitor Chemical Series Would Resolve Specific0.120.50C1Qproposed2026-04-18SDA-2026-04-17-gap-debate-20260417-033037-c43d12c2
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