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Hypotheses

2,369 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-b9c26a65TREM2 Agonism with CX3CR1 Antagonism for Microglial Homeostasis0.100.50TREM2proposed2026-04-18SDA-NEUROINFLAM-BIOMARKERPANEL-0b9129bc
h-f886036dP2RX7-PANX1 Channel Blockade for Neuroinflammatory Cascade Interruption0.100.50proposed2026-04-18SDA-NEUROINFLAM-BIOMARKERPANEL-0b9129bc
h-887bddf5AQP4 Water Channel Normalization as Surrogate Marker and Therapeutic Target0.100.50proposed2026-04-18SDA-NEUROINFLAM-BIOMARKERPANEL-0b9129bc
h-1ed9eec4CD300f Immunoglobulin Receptor as Neuroinflammatory Brake0.100.50proposed2026-04-18SDA-NEUROINFLAM-BIOMARKERPANEL-0b9129bc
h-9e51501aTYROBP Causal Network Inhibition for Microglial Repolarization0.100.50proposed2026-04-18SDA-NEUROINFLAM-BIOMARKERPANEL-0b9129bc
h-5e0c4ddfIL-33/ST2 Axis Augmentation for Synaptic Protection0.100.50proposed2026-04-18SDA-NEUROINFLAM-BIOMARKERPANEL-0b9129bc
h-dacf4657NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhibition0.100.50proposed2026-04-18SDA-NEUROINFLAM-BIOMARKERPANEL-0b9129bc
h-df000ab0Alectinib's Putative C1q Binding Derives from Hydrophobic Aggregation Rather Tha0.100.50C1Qproposed2026-04-18SDA-2026-04-17-gap-debate-20260417-033037-c43d12c2
neuroinflammation-pa[Archived Hypothesis]0.050.45archived2026-04-18legacy-pre-pipeline-import-v1
h-4d5e6f7a[Archived Hypothesis]0.050.00archived2026-04-18legacy-pre-pipeline-import-v1
hyp_493636[Archived Hypothesis]0.050.00archived2026-04-18legacy-pre-pipeline-import-v1
h-SDA-2026-0416-0190[Archived Hypothesis]0.050.00archived2026-04-17legacy-pre-pipeline-import-v1
h-SDA-2026-0401-0001[Archived Hypothesis]0.050.00archived2026-04-17legacy-pre-pipeline-import-v1
h-test[Archived Hypothesis]0.050.00archived2026-04-17legacy-pre-pipeline-import-v1
H-000001[Archived Hypothesis]0.050.00archived2026-04-17legacy-pre-pipeline-import-v1
SDA-2025-02-27-897[Archived Hypothesis]0.050.00archived2026-04-17legacy-pre-pipeline-import-v1
nlrp3-inflammasome-p[Archived Hypothesis]0.050.50archived2026-04-17legacy-pre-pipeline-import-v1
h-000001[Archived Hypothesis]0.050.00archived2026-04-17legacy-pre-pipeline-import-v1
h-77e89f79[Archived Hypothesis]0.050.00archived2026-04-17legacy-pre-pipeline-import-v1
h-debate-414842a3f31Critical Evaluation of the Allen Brain SEA-AD MTG snRNA-seq Dataset0.000.55SEAproposed2026-04-29
h-debate-a08d62eafe9Methodological Evaluation of the SEA-AD MTG Differential Expression Dataset0.000.55SEAproposed2026-04-29
h-debate-0b981f1e439Methodological Vulnerabilities in the SEA-AD snRNA-seq Dataset0.000.55SEAproposed2026-04-29
h-debate-427bfcb0c2dCritical Evaluation of the Allen Brain SEA-AD Dataset Methodology0.000.55SEAproposed2026-04-29
h-debate-21fb4d29b33Synthesis and Constructive Resolution Toward Methodological Reformation in Inter0.000.55proposed2026-04-29
h-debate-95a74259aa1Statistical Underpowering and the Reproducibility Crisis in Mitochondrial Transf0.000.55proposed2026-04-29
h-debate-cdd42c290bbResolving Mechanistic Heterogeneity Through Precision Medicine and Staged Interv0.000.55ALSproposed2026-04-29
h-debate-fe7218bf407Advancing Beyond Traditional Druggability Through RNA-Guided Precision Therapeut0.000.55RNAproposed2026-04-29
h-debate-89896f73e10Addressing Falsification Through Integrated Multi-Target Framework0.000.55TDPproposed2026-04-29
h-debate-51ed53ada29Advancing Beyond Traditional Druggability Through RNA-Guided Precision Therapeut0.000.55RNAproposed2026-04-29
h-debate-718bb32a48dTargeting TDP-43 Phase Separation Through Selective RNA-Binding Modulation0.000.55TDPproposed2026-04-29
h-debate-809970effb8Concrete Development Roadmap and Final Position0.000.55proposed2026-04-29
h-debate-2cf8c8ca336Strategic Reframing and Targeted Innovation0.000.55CRISPRproposed2026-04-29
h-debate-b9cea28255aConvergent Multi-Modal CRISPR Architectures (Continued)0.000.55CRISPRproposed2026-04-29
h-debate-8eee3d97b8eNext-Generation CRISPR Innovations for Huntington's Disease0.000.55CRISPRproposed2026-04-29
h-debate-b33a7b68ff9Novel CRISPR-based Therapies for Huntington's Disease: A Multi-Target Precision 0.000.55CRISPRproposed2026-04-29
h-debate-2ec23560a24Addressing Unfalsifiability with Precision0.000.55ATACproposed2026-04-29
h-debate-c6818b9e921Defending and Extending the Adaptive Decline Model0.000.55PMIDproposed2026-04-29
h-debate-e7caaa726caAstrocyte-Neuron Metabolic Coupling as the Master Plasticity Gatekeeper0.000.55proposed2026-04-29
h-debate-4d2d3eb1daeAstrocyte-Neuron Metabolic Coupling as the Master Plasticity Gatekeeper0.000.55proposed2026-04-29
h-debate-829763a5efcMicroglia-mediated antigen presentation creates a peripheral sink for tau antibo0.000.55proposed2026-04-29SDA-2026-04-04-gap-tau-prop-20260402003221
h-debate-61c7a283cc0Endosomal escape is the critical intracellular bottleneck for propagation0.000.55proposed2026-04-29SDA-2026-04-04-gap-tau-prop-20260402003221
h-debate-267a7e805b7Exosome-mediated propagation is the dominant pathway for long-distance tau sprea0.000.55proposed2026-04-29SDA-2026-04-04-gap-tau-prop-20260402003221
h-debate-5d177c09e0aThe "Trans-Cellular Prion-Like Propagation of Transcriptional Memory" Model0.000.55SEAproposed2026-04-29analysis-SEAAD-20260402
h-debate-f72ec2606d1The "Selective Vulnerability through Metabolic Licensing" Model0.000.55SEAproposed2026-04-29analysis-SEAAD-20260402
h-debate-050a2e63993CD63-Targeted Exosome Cargo Selectivity0.000.55CD63proposed2026-04-29SDA-2026-04-02-gap-tau-prop-20260402003221
h-debate-74c0c34e453Synaptic VDAC1-Mediated Mitochondrial Tau Trafficking0.000.55VDAC1proposed2026-04-29SDA-2026-04-02-gap-tau-prop-20260402003221
h-debate-7fdb34e4612APOE-Mediated Tau Clearance Enhancement0.000.55APOEproposed2026-04-29SDA-2026-04-02-gap-tau-prop-20260402003221
h-debate-2bb456a643cFYN-Mediated Extracellular Vesicle Release Inhibition0.000.55FYNproposed2026-04-29SDA-2026-04-02-gap-tau-prop-20260402003221
h-debate-1de42f4188fGSK3β-Dependent Tau Phosphorylation Cycling Modulation0.000.55GSK3Bproposed2026-04-29SDA-2026-04-02-gap-tau-prop-20260402003221
h-debate-2a00cc4f41cMulti-Cell Type Aging Clock Synchronization0.000.55Multipleproposed2026-04-29SDA-2026-04-03-gap-seaad-v2-20260402032945
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