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Hypotheses

2,408 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-debate-854c27f7826Immune Checkpoint Modulation via TREM20.000.55TREM2proposed2026-04-28SDA-2026-04-06-gap-001
h-debate-db1d8d09a38Anti-Fibrotic TREM2 Antagonism for Chronic Neuroinflammation0.000.55TREM2proposed2026-04-28SDA-2026-04-06-gap-001
h-debate-49950d30b55Tissue-Specific TREM2 Targeting Strategy0.000.55TREM2proposed2026-04-28SDA-2026-04-06-gap-001
h-debate-5f3fb97877fCardiac-Inspired Neuroprotective TREM2hi Strategy0.000.55TREM2proposed2026-04-28SDA-2026-04-06-gap-001
h-debate-24496b9f55bAstrocyte Subtype-Specific Anti-Inflammatory Reprogramming0.000.55C3proposed2026-04-28SDA-2026-04-03-gap-seaad-v3-20260402063622
h-debate-5a9daed37b1Layer-Specific Interneuron Protection in Deep Cortical Layers0.000.55PVALBproposed2026-04-28SDA-2026-04-03-gap-seaad-v3-20260402063622
h-debate-23a6e5164ffOligodendrocyte Precursor Cell Activation for Remyelination0.000.55PDGFRAproposed2026-04-28SDA-2026-04-03-gap-seaad-v3-20260402063622
h-debate-9445b5b09ceBIN1 Neuronal Isoform Restoration in Vulnerable Excitatory Neurons0.000.55BIN1proposed2026-04-28SDA-2026-04-03-gap-seaad-v3-20260402063622
h-debate-d109f2d3c99Syndecan-Mediated Uptake Inhibition0.000.55SDC4proposed2026-04-28SDA-2026-04-03-gap-tau-prop-20260402003221
h-debate-09e85748b02BIN1-Targeted Extracellular Vesicle Trafficking Disruption0.000.55BIN1proposed2026-04-28SDA-2026-04-03-gap-tau-prop-20260402003221
h-debate-810ad6b712eHeparan Sulfate 3-O-Sulfation Modulators0.000.55HS3ST1proposed2026-04-28SDA-2026-04-03-gap-tau-prop-20260402003221
h-debate-12009b968f7Lysosomal Membrane Stabilization to Prevent Tau Seeding0.000.55LAMP1proposed2026-04-28SDA-2026-04-03-gap-tau-prop-20260402003221
h-debate-d0dc5412596Cathepsin D Enhancement for Tau Degradation0.000.55CTSDproposed2026-04-28SDA-2026-04-03-gap-tau-prop-20260402003221
h-debate-bf566d9f6f8TREM2 Agonist Therapy to Redirect Microglial Exosome Content0.000.55TREM2proposed2026-04-28SDA-2026-04-03-gap-tau-prop-20260402003221
h-debate-5e1dc36a912Cross-Cell Type Communication Restoration0.000.55Multipleproposed2026-04-28SDA-2026-04-03-gap-seaad-20260402025452
h-debate-1c57aa4321aMyelin Interface Restoration Therapy0.000.55OLIG2proposed2026-04-28SDA-2026-04-03-gap-seaad-20260402025452
h-debate-cfd264781c9APOE4-Microglial Lipid Metabolism Correction0.000.55PICALMproposed2026-04-28SDA-2026-04-03-gap-seaad-20260402025452
h-debate-7db304c9a9dCD33-Sialic Acid Pathway Modulation in Microglia0.000.55CD33proposed2026-04-28SDA-2026-04-03-gap-seaad-20260402025452
h-debate-118fe40083bHDAC/MITF Epigenetic Reprogramming of Microglia0.000.55HDAC1proposed2026-04-28SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402
h-debate-c298c021ddeCX3CR1-Targeted Regulatory T Cell Homing0.000.55CX3CR1proposed2026-04-28SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402
h-debate-a90fddb8d4aGalectin-3/TREM2 Competitive Inhibition Therapy0.000.55LGALS3proposed2026-04-28SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402
h-debate-09095fc7bdbDual Astrocyte-Microglia Phenotype Synchronization0.000.55STAT3proposed2026-04-28SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402
h-debate-5e8aa240b6eComplement C3/C3aR Synaptic Protection Therapy0.000.55C3AR1proposed2026-04-28SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402
h-debate-d2fcc106067MiT-TFE/LRRK2 Lysosomal Enhancement Therapy0.000.55LRRK2proposed2026-04-28SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402
h-debate-d44f916a935Astrocyte Metabolic State Biosensor Therapy0.000.55Engineered FRET sensorsproposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222618-e6a431dd
h-debate-1701b22cd72Astrocyte Fuel Preference Pharmacogenomics0.000.55HMGCS2proposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222618-e6a431dd
h-debate-4f356011b8eNeuron-Astrocyte Metabolic Mismatch Syndrome0.000.55SLC16A7proposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222618-e6a431dd
h-debate-4e350771f27Mitochondrial Coupling Restoration Therapy0.000.55PPARGC1Aproposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222618-e6a431dd
h-debate-85c1a0f0180Ethnicity-Tailored Autophagy Enhancement0.000.55ATG7, ATG5, MTOR, TFEBproposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222549-20260402
h-debate-e6cda06abeaPopulation-Stratified Blood-Brain Barrier Engineering0.000.55ABCB1, ABCC1, CLDN5, OCLNproposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222549-20260402
h-debate-b0363863140Population-Stratified Estrogen Receptor Modulation0.000.55ESR1, ESR2, CYP19A1proposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222549-20260402
h-debate-c97cafd2df9Ancestry-Specific Complement System Calibration0.000.55C1QA, C1QB, C1QC, C3proposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222549-20260402
h-debate-87ccee82a7dMetabolic Reprogramming via Population-Adapted APOE Variants0.000.55APOE, PPARA, PPARGproposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222549-20260402
h-debate-9069dde94d9Population-Specific Synaptic Pruning Modulation0.000.55TREM2, CD33, CX3CR1, P2RY12proposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222549-20260402
h-debate-f96ba83ab6eSynaptic Glucose Transporter Density as an Early Response Biomarker0.000.55SLC2A3, SNAP25proposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222618-c698b06a
h-debate-b5cb6de2735Sex-Specific Metabolic Biomarker Panels for Alzheimer's Therapeutic Response0.000.55PPARGC1A, ESR1proposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222618-c698b06a
h-debate-cceb703815aMulti-Modal Metabolic Connectivity Index for Disease Progression Monitoring0.000.55COMT, ATP synthase subunitsproposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222618-c698b06a
h-debate-35b63d336e6Synaptic Activity-Dependent Protection System0.000.55ARCproposed2026-04-28sda-2026-04-01-gap-v2-691b42f1
h-debate-5fbc939d943Temporal Modulation of Microglial Circadian Rhythms0.000.55CLOCKproposed2026-04-28sda-2026-04-01-gap-v2-691b42f1
h-debate-a32f3a7b954Fractalkine Axis Restoration for Neuroprotective Signaling0.000.55CX3CL1proposed2026-04-28sda-2026-04-01-gap-v2-691b42f1
h-debate-3c00a4d9758Engineered Anti-Complement Synaptic Tags0.000.55C3proposed2026-04-28sda-2026-04-01-gap-v2-691b42f1
h-debate-fea3c767950Complement C1q Blockade for Selective Pruning Prevention0.000.55C1QAproposed2026-04-28sda-2026-04-01-gap-v2-691b42f1
h-debate-eb681c54a63TREM2 Functional Modulation for Pruning Precision0.000.55TREM2proposed2026-04-28sda-2026-04-01-gap-v2-691b42f1
h-debate-6a4d4a8e575Metabolic Reprogramming of Pruning Microglia0.000.55PKM2proposed2026-04-28sda-2026-04-01-gap-v2-691b42f1
h-debate-08b25f669c2Microglial Priming Reset via Short-Chain Fatty Acid Epigenetic Modulation0.000.55HDAC2, HDAC3, CD68, TREM2proposed2026-04-28sda-2026-04-01-003
h-debate-f0d4e5cf357Personalized Microbiome Therapeutic Precision Medicine0.000.55Multiple individualizedproposed2026-04-28sda-2026-04-01-003
h-debate-ebef2e11633Gut Barrier Reconstruction via Polysaccharide-Probiotic Synbiotics0.000.55CLDN1, TJP1, TLR4, NFKB1proposed2026-04-28sda-2026-04-01-003
h-debate-ee4b4bfff9aGlycolytic Inhibition Selectively Blocks Reactive Astrocyte Complement Productio0.000.55PFKFB3proposed2026-04-28sda-2026-04-01-gap-009
h-debate-ea98eea802bHyaluronidase Treatment Disrupts Perivascular Inflammatory Niches0.000.55CD44proposed2026-04-28sda-2026-04-01-gap-009
h-debate-3bc431ab7bbPiezo1 Channel Inhibition Prevents Mechanical Amplification of Astrocyte Reactiv0.000.55PIEZO1proposed2026-04-28sda-2026-04-01-gap-009
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