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Hypotheses

2,369 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-debate-bcfe8fd4aa0FcRn Transport Pathway Enhancers0.000.55FCGRTproposed2026-04-29SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-debate-e0d69bf9bc4FcRn Expression Biomarker-Guided Dosing0.000.55FCGRTproposed2026-04-29SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-debate-37d724d61eaDual-Pathway BBB Transport Optimization0.000.55TFRCproposed2026-04-29SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-debate-187ca49da92Alternative Fc Engineering for BBB Specificity0.000.55FCGRTproposed2026-04-29SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-debate-7e76e916406Species-Optimized Preclinical Models0.000.55FCGRTproposed2026-04-29SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-debate-f676b157978Perinatal Epigenetic Reprogramming as AD Prevention0.000.55DNMT3Aproposed2026-04-29SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-debate-0a8683288e8Epigenetic Memory Erasure in Aged Microglia0.000.55DNMT1proposed2026-04-29SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-debate-35bb97dcd03Gut-Brain Axis Microglial Depriming Strategy0.000.55TLR4proposed2026-04-29SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-debate-336ed22589aSynaptic-Microglial Interface Restoration0.000.55C1Qproposed2026-04-29SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-debate-ffb8f8a629eIGFBPL1-Mediated Microglial Homeostasis Reset Therapy0.000.55IGFBPL1proposed2026-04-29SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-debate-0bf4d4b39f8Temporal Processing Enhancement Hypothesis0.000.55PVALBproposed2026-04-29SDA-2026-04-04-gap-debate-20260403-222510-20260402
h-debate-4a67c759233Cross-Modal Integration Hypothesis0.000.55MBPproposed2026-04-29SDA-2026-04-04-gap-debate-20260403-222510-20260402
h-debate-92a6999ffbaCognitive Load Optimization Hypothesis0.000.55GABRA1proposed2026-04-29SDA-2026-04-04-gap-debate-20260403-222510-20260402
h-debate-a4bd1cea341Semantic Network Enhancement Hypothesis0.000.55GRIN2Bproposed2026-04-29SDA-2026-04-04-gap-debate-20260403-222510-20260402
h-debate-b60813d08f8Dopaminergic Cognitive Enhancement Hypothesis0.000.55COMTproposed2026-04-29SDA-2026-04-04-gap-debate-20260403-222510-20260402
h-debate-75ecad310edMetabolic Reprogramming of SPP1-Activated Microglia0.000.55HK2proposed2026-04-29SDA-2026-04-15-gap-pubmed-20260406-062118-e3613755
h-debate-054eb313c10CD44-SPP1 Axis Precision Targeting0.000.55CD44proposed2026-04-29SDA-2026-04-15-gap-pubmed-20260406-062118-e3613755
h-debate-4a8adbe2ea0Complement-Independent SPP1 Signaling Disruption0.000.55RHOAproposed2026-04-29SDA-2026-04-15-gap-pubmed-20260406-062118-e3613755
h-debate-8dcbfbea61fSPP1-Integrin Competitive Inhibition0.000.55ITGAVproposed2026-04-29SDA-2026-04-15-gap-pubmed-20260406-062118-e3613755
h-debate-f1235f1ab16Circadian Metabolic Rhythm Restoration0.000.55NR1D1, CLOCK, BMAL1proposed2026-04-29SDA-2026-04-02-gap-v2-e1e1b7c3
h-debate-78c124518c7Metabolic Compartmentalization Therapy0.000.55MCT2, regional metabolic enzymesproposed2026-04-29SDA-2026-04-02-gap-v2-e1e1b7c3
h-debate-0847d0d9d79Mitochondrial Biogenesis Rescue via PGC-1α Activation0.000.55PPARGC1A, mitochondrial transcription factorsproposed2026-04-29SDA-2026-04-02-gap-v2-e1e1b7c3
h-debate-0d109cd2f85Astrocyte-Microglia Metabolic Cross-Talk Modulation0.000.55MCT1, MCT4, HMGCS2proposed2026-04-29SDA-2026-04-02-gap-v2-e1e1b7c3
h-debate-a40973dd495Trained Immunity Metabolic Reset0.000.55HK2, PKM2, mevalonate pathway enzymesproposed2026-04-29SDA-2026-04-02-gap-v2-e1e1b7c3
h-debate-646d075352bIron-Metabolism-Inflammasome Axis Disruption0.000.55GPX4, ACSL4, NLRP3proposed2026-04-29SDA-2026-04-02-gap-v2-e1e1b7c3
h-debate-c1907c4deebNETs-MMP-Wnt Axis Therapeutic Cascade0.000.55proposed2026-04-29SDA-2026-04-16-gap-bbb-tjp-20260416041707
h-debate-f6af368e805Peripheral-to-Central Inflammatory Relay Disruption0.000.55proposed2026-04-29SDA-2026-04-16-gap-bbb-tjp-20260416041707
h-debate-404ce754f7aTemporal Cytokine Window Therapeutic Intervention0.000.55proposed2026-04-29SDA-2026-04-16-gap-bbb-tjp-20260416041707
h-debate-eadd0fa5911PS Exposure is Cell-Type Context-Dependent Rather Than Pathway-Specific0.000.55PS-binding receptor complexes (MERTK, AXL, TIMD4)proposed2026-04-29SDA-2026-04-10-gap-debate-20260410-100359-5f096b45
h-debate-b1b2a430511PS Externalization Requires Tau Aggregation-Phase Transition0.000.55Tau liquid-liquid phase separation intermediates, membrane cproposed2026-04-29SDA-2026-04-10-gap-debate-20260410-100359-5f096b45
h-debate-634ae1543ccOxidative Stress-Induced PS Exposure is Bnip3-Dependent in Tauopathy0.000.55BNIP3, MFN2 (mitochondrial dynamics)proposed2026-04-29SDA-2026-04-10-gap-debate-20260410-100359-5f096b45
h-debate-31ffa65ca9fHyperphosphorylated Tau Inhibits PMCA Pumps, Causing Sustained PS Exposure0.000.55ATP2B1 (PMCA1), ATP2B4 (PMCA4), TMEM16F, XKR4proposed2026-04-29SDA-2026-04-10-gap-debate-20260410-100359-5f096b45
h-debate-ca8623bb619Regional Vulnerability Reflects Microglial PS-Sensing Heterogeneity0.000.55CX3CR1, microglial PS receptors (MERTK, AXL), regional transproposed2026-04-29SDA-2026-04-10-gap-debate-20260410-100359-5f096b45
h-debate-b2a3bf9e4bfCaspase-3 Cleavage of Tau Creates PS-Targeting Specificity0.000.55CASP3, tau cleavage products (ΔD25, ΔD391)proposed2026-04-29SDA-2026-04-10-gap-debate-20260410-100359-5f096b45
h-debate-3f5d76326a6Dual-Signal Model: PS + Tau N-terminal Fragments Enable Selective Targeting0.000.55Tau N-terminal fragments (aa 1-150), PS externalizationproposed2026-04-29SDA-2026-04-10-gap-debate-20260410-100359-5f096b45
h-debate-1324f7b68eePioneer Factor-Mediated Stimulus Filtering0.000.55FOXA1, PU.1, GATA1proposed2026-04-29SDA-2026-04-10-gap-debate-20260410-095952-12fad421
h-debate-eb438fd7088Super-Enhancer Hierarchy Model0.000.55BRD4, MED1, enhancer RNAs (eRNAs)proposed2026-04-29SDA-2026-04-10-gap-debate-20260410-095952-12fad421
h-debate-781bdec4451Bivalent Domain Resolution as Stimulus Decoder0.000.55KDM6B (JMJD3), EZH2, UTX, RNF20proposed2026-04-29SDA-2026-04-10-gap-debate-20260410-095952-12fad421
h-debate-a698da25763Phagocytic Receptor (CSF1R)-Mediated Uptake of Circadian-Modifying Peptides0.000.55CSF1R / PER2proposed2026-04-29SDA-2026-04-10-gap-debate-20260410-095945-976d542d
h-debate-2162e92f50dTREM2 Ligand-Conjugated Nanocarriers for Microglial Circadian Modulator Delivery0.000.55TREM2 receptorproposed2026-04-29SDA-2026-04-10-gap-debate-20260410-095945-976d542d
h-debate-715a4183702CX3CR1-Cre-Driven BMAL1 Deletion as Microglial Circadian Clock Ablation0.000.55BMAL1 (ARNTL) / CX3CR1 promoterproposed2026-04-29SDA-2026-04-10-gap-debate-20260410-095945-976d542d
h-debate-762aa36a168Microglial-Specific miR-132/212 Cluster Delivery to Modulate Circadian Gene Netw0.000.55miR-132 / REV-ERBα (NR1D1)proposed2026-04-29SDA-2026-04-10-gap-debate-20260410-095945-976d542d
h-debate-e79aa9df18fAstrocyte-Microglia Circadian Coupling via Extracellular Vesicle Transport0.000.55PER2 / CRY1 / SIRT1proposed2026-04-29SDA-2026-04-10-gap-debate-20260410-095945-976d542d
h-debate-798ab8caa6eMicroglial NLRP3 Inflammasome as Circadian-Specific Drug Target0.000.55NLRP3 inflammasome / BMAL1proposed2026-04-29SDA-2026-04-10-gap-debate-20260410-095945-976d542d
h-debate-5522db93188P2Y12 Receptor-Mediated Phase Resetting of Circadian Inflammatory Rhythms0.000.55P2Y12 / BMAL1-CLOCK complexproposed2026-04-29SDA-2026-04-10-gap-debate-20260410-095945-976d542d
h-debate-d5862b41ad6Bile Acid Signaling Disruption Cascade0.000.55proposed2026-04-29SDA-2026-04-11-gap-debate-20260410-111558-f9487fea
h-debate-c77ea962308Prevotellaceae as Dopamine Precursor Modulators0.000.55proposed2026-04-29SDA-2026-04-11-gap-debate-20260410-111558-f9487fea
h-debate-8dff48967c6Circadian Rhythm Disruption via Microbiome-Clock Axis0.000.55proposed2026-04-29SDA-2026-04-11-gap-debate-20260410-111558-f9487fea
h-debate-2af67e4bdf2Systemic Metabolic Reprogramming via Prevotellaceae Loss0.000.55proposed2026-04-29SDA-2026-04-11-gap-debate-20260410-111558-f9487fea
h-debate-02154a51ed0Prevotellaceae-Mediated Enteric Nervous System Priming Theory0.000.55proposed2026-04-29SDA-2026-04-11-gap-debate-20260410-111558-f9487fea
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