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Hypotheses

2,408 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-debate-87b23448b2emTOR Inhibition Promotes Astrocytic Clearance of Inflammatory Proteins0.000.55MTORproposed2026-04-28sda-2026-04-01-gap-009
h-debate-2badd69abf6Timed Melatonin Administration Exploits Circadian Vulnerability of Microglial Ac0.000.55CLOCKproposed2026-04-28sda-2026-04-01-gap-009
h-debate-a47a35ffb2aSequential IL-1α and Complement Receptor Antagonism for Breaking Neuroinflammato0.000.55IL1Aproposed2026-04-28sda-2026-04-01-gap-009
h-debate-5820d3aa5adSpecialized Pro-Resolving Mediator Biosynthesis Enhancement in Astrocytes0.000.55ALOX15proposed2026-04-28sda-2026-04-01-gap-009
h-debate-262ef358ac7Membrane Lipid Raft Reorganization Therapy0.000.55HMGCRproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062207-5a703c17
h-debate-d1a0ce6a506Cellular Stress Response Hijacking Prevention0.000.55PERKproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062207-5a703c17
h-debate-fff879b3eddChaperone Hijacking Interference Therapy0.000.55HSP70proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062207-5a703c17
h-debate-3e7c779e649Metabolic-Complement Coupling0.000.55ATP5F1A, NDUFA1, CD55proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062128-34a47c4e
h-debate-999016a0046Synaptic Tagging Differential Vulnerability0.000.55CALR, PTDSS1, ANXA5proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062128-34a47c4e
h-debate-ee760695b59Neurotransmitter-Specific Synapse Targeting0.000.55CHAT, GAD1, C3AR1proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062128-34a47c4e
h-debate-17c8c7447c3Circuit-Specific Complement Targeting0.000.55C1QA, C3, CR1proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062128-34a47c4e
h-debate-2ff599b4ca3Microglial State-Dependent Synapse Selection0.000.55TREM2, CD68, CSF1Rproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062128-34a47c4e
h-debate-cdf5635812dAstrocytic Complement Regulation Hypothesis0.000.55CD55, CD46, GFAPproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062128-34a47c4e
h-debate-cc67023d5cdTemporal Complement Activation Windows0.000.55C3AR1, C5AR1, C1QAproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062128-34a47c4e
h-debate-784fe9aeca5Mitochondrial Biogenesis Reset Theory0.000.55proposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062101-7751c220
h-debate-87cc4654eddMetabolic Switch Competency Model0.000.55proposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062101-7751c220
h-debate-563935a74d6Senescence Exit Gateway Hypothesis0.000.55proposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062101-7751c220
h-debate-0f6c96d8817Spatiotemporal Astrocyte Subtype Gradients for Tissue Repair0.000.55Multipleproposed2026-04-28sda-2026-04-01-gap-007
h-debate-60cbd2df0aeEpigenetic State Locking of Beneficial Astrocyte Subtypes0.000.55HDAC/BET/DNMTproposed2026-04-28sda-2026-04-01-gap-007
h-debate-1d1606a1ab9ARAP3-Mediated Microglial-Astrocyte Cross-Talk Modulation0.000.55ARAP3proposed2026-04-28sda-2026-04-01-gap-007
h-debate-10f5feadbfeMetabolic Memory Reprogramming via Molecular Switches0.000.55Undefinedproposed2026-04-28sda-2026-04-01-gap-007
h-debate-d8a4f37e2e4Temporal Nrf2-mTOR Dual Switch Therapy0.000.55NFE2L2/MTORproposed2026-04-28sda-2026-04-01-gap-007
h-debate-6b42d510d17GLP-1R-Astrocyte Axis for Cognitive Rescue0.000.55GLP1Rproposed2026-04-28sda-2026-04-01-gap-007
h-debate-27e707b6d8eBioenergetic Checkpoint Modulation for Astrocyte Fate Control0.000.55AMPK/MTOR/SIRT1proposed2026-04-28sda-2026-04-01-gap-007
h-debate-00e338cbe91Tissue-Specific Protein Complex Assembly Therapy0.000.55Tissue-specific scaffolding proteins and complex assembly faproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522
h-debate-8dbc1c05188Differential Protein Folding Environment Therapy0.000.55HSP70, HSP90, tissue-specific co-chaperonesproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522
h-debate-3d3546e2627Tissue-Specific Stress Response Pathway Enhancement0.000.55NRF2, ATF4, HSF1, tissue-specific stress response transcriptproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522
h-debate-e46dc8376acMetabolic State-Dependent Protein Function Modulation0.000.55AMPK, mTOR pathway components, tissue-specific metabolic enzproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522
h-debate-95c109a91f7Ganglioside Rebalancing Therapy via ST3GAL5 Modulation0.000.55ST3GAL5proposed2026-04-28SDA-2026-04-04-frontier-lipidomics-dcdbc360
h-debate-c4a3b6f3eefPhosphoinositide Signaling Restoration via PIP5K1C Activation0.000.55PIP5K1Cproposed2026-04-28SDA-2026-04-04-frontier-lipidomics-dcdbc360
h-debate-4d7b8789cfaSpecialized Pro-Resolving Mediator Enhancement via ALOX15 Modulation0.000.55ALOX15proposed2026-04-28SDA-2026-04-04-frontier-lipidomics-dcdbc360
h-debate-dedb5482e61Very-Long-Chain Fatty Acid Normalization via ELOVL1/4 Dual Targeting0.000.55ELOVL1, ELOVL4proposed2026-04-28SDA-2026-04-04-frontier-lipidomics-dcdbc360
h-debate-fd4c5d1435fCeramide-Sphingosine-1-Phosphate Axis Rebalancing via SPHK1 Enhancement0.000.55SPHK1proposed2026-04-28SDA-2026-04-04-frontier-lipidomics-dcdbc360
h-debate-2669f584d5eAPOE Lipidation Enhancement via ABCA1 Superactivation0.000.55ABCA1proposed2026-04-28SDA-2026-04-04-frontier-lipidomics-dcdbc360
h-debate-6a7ac6e2b89ATP-Mimetic Phase Separation Modulators0.000.55TARDBPproposed2026-04-28sda-2026-04-01-gap-006
h-debate-d71b812a756Prion-Like Domain Stabilizers via Aromatic Interaction Modulators0.000.55TARDBPproposed2026-04-28sda-2026-04-01-gap-006
h-debate-ac3b63c9a8eNuclear Import Receptor Enhancers0.000.55TARDBPproposed2026-04-28sda-2026-04-01-gap-006
h-debate-6d4773e443bC9orf72 DPR Neutralizing Agents0.000.55C9orf72proposed2026-04-28sda-2026-04-01-gap-006
h-debate-689ba7a7d15FcRn Transport Saturation Therapy0.000.55FCGRTproposed2026-04-28SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-debate-bcfe8fd4aa0FcRn Transport Pathway Enhancers0.000.55FCGRTproposed2026-04-28SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-debate-e0d69bf9bc4FcRn Expression Biomarker-Guided Dosing0.000.55FCGRTproposed2026-04-28SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-debate-37d724d61eaDual-Pathway BBB Transport Optimization0.000.55TFRCproposed2026-04-28SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-debate-187ca49da92Alternative Fc Engineering for BBB Specificity0.000.55FCGRTproposed2026-04-28SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-debate-7e76e916406Species-Optimized Preclinical Models0.000.55FCGRTproposed2026-04-28SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
h-debate-f676b157978Perinatal Epigenetic Reprogramming as AD Prevention0.000.55DNMT3Aproposed2026-04-28SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-debate-0a8683288e8Epigenetic Memory Erasure in Aged Microglia0.000.55DNMT1proposed2026-04-28SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-debate-35bb97dcd03Gut-Brain Axis Microglial Depriming Strategy0.000.55TLR4proposed2026-04-28SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-debate-336ed22589aSynaptic-Microglial Interface Restoration0.000.55C1Qproposed2026-04-28SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-debate-ffb8f8a629eIGFBPL1-Mediated Microglial Homeostasis Reset Therapy0.000.55IGFBPL1proposed2026-04-28SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
h-debate-0bf4d4b39f8Temporal Processing Enhancement Hypothesis0.000.55PVALBproposed2026-04-28SDA-2026-04-04-gap-debate-20260403-222510-20260402
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