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Hypotheses

2,408 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-debate-ca7cd06fbe9Membraneless Organelle Stabilizers Targeting Low-Complexity Domains0.000.55TARDBPproposed2026-04-28sda-2026-04-01-gap-006
h-debate-cc1a80961f9G4C2 RNA Decoy Therapeutics0.000.55C9orf72proposed2026-04-28sda-2026-04-01-gap-006
h-debate-bccf51838eaPhase Transition Kinetics Modulators0.000.55TARDBPproposed2026-04-28sda-2026-04-01-gap-006
h-debate-2bd1fc31f6eNuclear Import Receptor Enhancers as Phase Separation Modulators0.000.55TARDBPproposed2026-04-28sda-2026-04-01-gap-006
h-debate-516516c6941Arginine-Rich DPR Competitive Inhibitors0.000.55C9orf72proposed2026-04-28sda-2026-04-01-gap-006
h-debate-6024ce76e0cInnate Immunity Memory Erasure Protocol0.000.55KDM1Aproposed2026-04-28SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-73c94b586b3Synaptic Chromatin Compartment Rejuvenation0.000.55CREBBPproposed2026-04-28SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-e1f2c6598ffPartial Reprogramming with Chromatin Velocity Control0.000.55BRD4proposed2026-04-28SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-0aa85875f42Temporal Chromatin Oscillator Reset Therapy0.000.55KLF4proposed2026-04-28SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-70b72b9966dEpigenetic Clock Reversal via Metabolic Oscillator Coupling0.000.55SIRT1proposed2026-04-28SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-4e3485ffd63Metabolic-Epigenetic Coupling Restoration via ApoE Mimetics0.000.55APOEproposed2026-04-28SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-9a99b2c74b6Glial-Neuronal Epigenetic Cross-Talk Restoration0.000.55APOEproposed2026-04-28SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-debate-c209826cba1Synthetic Biology Circuits for Network Homeostasis0.000.55Network homeostasis machineryproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-25cee9bfa90Optogenetic Control of Protein Interactions0.000.55Disease-affected interaction proteinsproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-6ece528a0b9Proximity-Induced Degradation of Mislocalized Proteins0.000.55Mislocalized disease proteinsproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-58f24b61f38Synthetic Compartmentalization Therapy0.000.55Compartmentalization machineryproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-8523fd7b01eRNA-Guided Subcellular Protein Targeting0.000.55Mislocalized disease proteinsproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-52d41369285Chaperone-Mediated Interaction Rescue0.000.55Disease-specific interaction domainsproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-4f9f0b3525bSmall Molecule Interaction Stabilizers0.000.55Multiple interaction hub proteinsproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
h-debate-ba7fcef7263Phase Separation Modifier Compounds0.000.55Multiple condensate proteinsproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-9b9a295107bMultivalent RNA-Binding Domain Inhibitors0.000.55TP53BP1proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-b6249bf13b7Preinitiation Complex Assembly Modulators0.000.55TBPproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-96b36f67bd3RNA Polymerase II CTD Phosphatase Modulators0.000.55POLR2Aproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-8afcc11e534RNA-Dependent Condensate Maturation Inhibitors0.000.55Multiple DDR proteinsproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-e7034c03db5MRN Complex-PIC Interaction Disruptors0.000.55RAD50proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-10550664d87Sequence-Specific RNA Antisense Oligonucleotides (ASOs) for dilncRNA Depletion0.000.55dilncRNAsproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
h-debate-772daf86516RNA Aptamer-Mediated Therapeutic Condensate Hijacking0.000.5553BP1proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95
h-debate-52884dbaab7Condensate Permeability Modulators for Protein Quality Control0.000.5553BP1proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95
h-debate-151eb035421Multivalent Decoy Proteins for Condensate Redirection0.000.55SNCAproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95
h-debate-7b80773c106RNA-Guided Condensate Reprogramming for Neuroprotection0.000.5553BP1proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95
h-debate-3eb94204c34Aberrant Condensate Dissolution Therapy0.000.5553BP1proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95
h-debate-fbca3a2cb8eIDR Competition Therapy0.000.55MAPTproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95
h-debate-b9654013c07Condensate-Targeted Drug Delivery via Phase Partitioning0.000.5553BP1proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95
h-debate-1ebce88bd6aAmyloid Precursor Protein Processing Modulation via Bacterial Enzyme Delivery0.000.55APPproposed2026-04-28gut-brain-ad
h-debate-3d0224c4d9dVagal Nerve Stimulation Enhancement Through Targeted Lactobacillus Strains0.000.55CHRNA7proposed2026-04-28gut-brain-ad
h-debate-cc59828a0acSelective Microglial Reprogramming via Engineered Probiotic Metabolites0.000.55TREM2proposed2026-04-28gut-brain-ad
h-debate-b4b76fbe8d9Circadian Rhythm Synchronization via Microbiome Entrainment0.000.55CLOCKproposed2026-04-28gut-brain-ad
h-debate-63ca4dc70e9Personalized Microbiome Restoration Based on Individual Aβ Clearance Capacity0.000.55IDEproposed2026-04-28gut-brain-ad
h-debate-fa8586891ceMulti-Target Synbiotic Platform for Simultaneous Neuroprotection and Neuroregene0.000.55BDNFproposed2026-04-28gut-brain-ad
h-debate-4bd9316085eGut Barrier Restoration to Prevent Bacterial Translocation and Systemic Inflamma0.000.55TLR4proposed2026-04-28gut-brain-ad
h-debate-6956bb562c8Metabolic Reprogramming via Lactate Utilization0.000.55SLC16A7proposed2026-04-28sda-2026-04-01-gap-004
h-debate-2752055db5cMitochondrial Calcium Buffering Enhancement0.000.55MCUproposed2026-04-28sda-2026-04-01-gap-004
h-debate-23957d6c6d3Glial-Stellate Metabolic Coupling Enhancement0.000.55GJA1proposed2026-04-28sda-2026-04-01-gap-004
h-debate-61fb3648dafReelin Signaling Enhancement0.000.55RELNproposed2026-04-28sda-2026-04-01-gap-004
h-debate-c16a4d605b1Ion Channel Stabilization (HCN1/Kv7)0.000.55HCN1proposed2026-04-28sda-2026-04-01-gap-004
h-debate-ce2e6632ca4Autophagy Enhancement via TFEB Activation0.000.55TFEBproposed2026-04-28sda-2026-04-01-gap-004
h-debate-f1253aaeed6Cholinergic Modulation via α7 Nicotinic Receptors0.000.55CHRNA7proposed2026-04-28sda-2026-04-01-gap-004
h-debate-e38f8f72829Cellular Defense Strategy Modulation0.000.55HSPA1Aproposed2026-04-28sda-2026-04-01-gap-005
h-debate-96fad5bea8cDisease Stage Reprogramming0.000.55SOX2proposed2026-04-28sda-2026-04-01-gap-005
h-debate-6f974ef42f0Astrocytic Surface Glycoprotein Modulation0.000.55MUC1proposed2026-04-28sda-2026-04-01-gap-005
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