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Hypotheses

2,408 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-debate-ce7761a039fMAPT Transcriptional Control0.000.55MAPTproposed2026-04-28sda-2026-04-01-gap-005
h-debate-baba8b6100dChromatin Remodeling for Tau-Associated Gene Expression0.000.55HDAC1proposed2026-04-28sda-2026-04-01-gap-005
h-debate-c3b0e62f7b7NRF2 Pathway Activation for Neuroprotection0.000.55NFE2L2proposed2026-04-28sda-2026-04-01-gap-005
h-debate-31b1db1e857Autophagy Enhancement for Tau Clearance0.000.55ATG7proposed2026-04-28sda-2026-04-01-gap-005
h-debate-bb090684c56Exosomal Autophagosome Transfer System0.000.55LC3Bproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062212-b66510d9
h-debate-957d23cf0d2Astrocytic SQSTM1 Overexpression Therapy0.000.55SQSTM1proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062212-b66510d9
h-debate-906054055bdOligodendroglial Autophagy Enhancement0.000.55ATG7proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062212-b66510d9
h-debate-74d4cecf482Trehalose-Resistant Autophagy Bypass Pathway0.000.55ULK1proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062212-b66510d9
h-debate-ce3e7a9a3fcMicroglial Autophagy Priming Therapy0.000.55MTORproposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062212-b66510d9
h-debate-ca96b340b8bIntercellular Mitophagy Communication Network0.000.55PINK1proposed2026-04-28SDA-2026-04-08-gap-pubmed-20260406-062212-b66510d9
h-debate-2ac2b576b08Stress-Activated Retrotransposon Epigenetic Regulation (SARER)0.000.55TRIM28proposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062039-f02efa4b
h-debate-da4bd95f955Temporal Epigenetic Switch Points (TESP)0.000.55CLOCKproposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062039-f02efa4b
h-debate-6077bb292cfParacrine Epigenetic Signaling Networks (PESN)0.000.55miR-155proposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062039-f02efa4b
h-debate-1ea5d1f402cStress-Responsive Epigenetic Memory (SREM)0.000.55EZH2proposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062039-f02efa4b
h-debate-748b48b3a83Mechanosensitive Epigenetic Transcription (MET)0.000.55YAP1proposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062039-f02efa4b
h-debate-5d2bedefac8Convergent Chromatin Remodeling Cascade (CRC)0.000.55HDAC2proposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062039-f02efa4b
h-debate-a541706ec31Metabolic-Epigenetic Coupling Interface (MECI)0.000.55SIRT1proposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062039-f02efa4b
h-debate-555b51502d8TREM2 Gradient-Based Drug Delivery0.000.55TREM2proposed2026-04-28trem2-ad
h-debate-eec38ce2041TREM2-Mediated Fibrotic Prevention in Neurodegeneration0.000.55TREM2proposed2026-04-28trem2-ad
h-debate-ce48afac076Immunological Niche Transition Targeting0.000.55TREM2proposed2026-04-28trem2-ad
h-debate-5435d088817Combination Therapy: TREM2 + T-cell Modulation0.000.55TREM2proposed2026-04-28trem2-ad
h-debate-639e4a0edb2Metabolic Reprogramming via TREM2-Mitochondrial Axis0.000.55TREM2proposed2026-04-28trem2-ad
h-debate-b4ed155766aTREM2-Apoptosis Axis for Cellular Clearance0.000.55TREM2proposed2026-04-28trem2-ad
h-debate-1a22e13feffTemporal TREM2 Modulation for Alzheimer's Therapy0.000.55TREM2proposed2026-04-28trem2-ad
h-debate-adcc46636dfAdaptive Deep Brain Stimulation Targeting the Pedunculopontine Nucleus0.000.55GBAproposed2026-04-28gba-pd
h-debate-ebaf8669e5aLysosomal Membrane Stabilization as Upstream GBA Therapy0.000.55GBAproposed2026-04-28gba-pd
h-debate-624ccea7e1eNeuroinflammation Biomarker-Guided Immunomodulation for GBA Carriers0.000.55IL1Bproposed2026-04-28gba-pd
h-debate-2cd6bbdefeaCombinatorial TFEB Activation and Anti-Inflammatory Therapy0.000.55TFEBproposed2026-04-28gba-pd
h-debate-4ab1496bc9aPersonalized DBS Programming Based on GBA Genotype-Specific Neural Signatures0.000.55GBAproposed2026-04-28gba-pd
h-debate-456c4d12c8eFreezing-of-Gait Prediction Algorithm Using GBA Mutation Status0.000.55GBAproposed2026-04-28gba-pd
h-debate-28a19fae67cTFEB-Mediated Autophagy Enhancement as a Circuit Breaker for the GBA-Synuclein L0.000.55TFEBproposed2026-04-28gba-pd
h-debate-329991626a9pH-Sensitive Tau Vesicle Targeting0.000.55MAPTproposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd
h-debate-c4385a075deVesicle Surface Glycan Pattern Recognition0.000.55MAPTproposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd
h-debate-810c1e5a5acTau-Induced Lipid Membrane Asymmetry Exploitation0.000.55MAPTproposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd
h-debate-f7e4ecbf7b3Tau Conformational State-Specific Nanobody Targeting0.000.55MAPTproposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd
h-debate-16810224092Tau Post-Translational Modification State Targeting0.000.55MAPTproposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd
h-debate-e52f9e63944Chaperone Co-localization Guided Delivery0.000.55HSPA1Aproposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd
h-debate-05624b1daeeAutophagosome Marker Hijacking Strategy0.000.55MAP1LC3Aproposed2026-04-28SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd
h-debate-075de316a0bGlial Scar Architecture Manipulation for Functional Compartmentalization0.000.55ARAP3, cytoskeletal regulatorsproposed2026-04-28astrocyte-subtypes
h-debate-3cd1c9d33eaNrf2-NF-κB Oscillatory Circuit Modulation0.000.55NFE2L2, NFKB1proposed2026-04-28astrocyte-subtypes
h-debate-10f2f867bbaNascent Transcript Targeting for Real-Time Reprogramming0.000.55RNA processing machineryproposed2026-04-28astrocyte-subtypes
h-debate-cfec1a7354aTemporal mTOR Modulation for Sequential A1/A2 Switching0.000.55MTORproposed2026-04-28astrocyte-subtypes
h-debate-49e9c1f5ecaCombinatorial Il-1α/TNFα/C1q Antagonism with Selective Agonism0.000.55IL1A, TNF, C1QA, NFE2L2proposed2026-04-28astrocyte-subtypes
h-debate-dfbbb1f6b9fMicroglial GLP-1R-Mediated Astrocyte Programming0.000.55GLP1R, ARAP3proposed2026-04-28astrocyte-subtypes
h-debate-698ff0b1f07Age-Stratified Astrocyte Subtype Switching0.000.55Multiple age-dependent switchesproposed2026-04-28astrocyte-subtypes
h-debate-68fd2b81578Bi-directional Transcytosis Inhibition Strategy0.000.55ABCB1 (P-glycoprotein), ABCG2 (BCRP), APP/Aβproposed2026-04-28sda-2026-04-01-gap-008
h-debate-24170addd30Intranasal Delivery of BBB-Penetrating Antibody Conjugates0.000.55APP/Aβ, olfactory receptor neuronsproposed2026-04-28sda-2026-04-01-gap-008
h-debate-477286ec859Engineered Exosome-Encapsulated Antibody Fragments0.000.55APP/Aβ, TFRC, lactoferrin receptorproposed2026-04-28sda-2026-04-01-gap-008
h-debate-a513718a3eeCell-Penetrating Peptide Conjugated Nanobodies0.000.55APP/Aβ oligomers, various CPP sequencesproposed2026-04-28sda-2026-04-01-gap-008
h-debate-72a94a5767cLRP1-Mediated Trojan Horse Delivery System0.000.55LRP1 (low-density lipoprotein receptor-related protein 1), Aproposed2026-04-28sda-2026-04-01-gap-008
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