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Hypotheses

2,408 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-debate-c017235110fGlymphatic Enhancement Through Controlled Sleep Depth Modulation0.000.55N/A (Sleep Architecture)proposed2026-04-28sda-2026-04-01-gap-v2-18cf98ca
h-debate-e9062cec160Chronotherapeutic Orexin Modulation for Tau Clearance0.000.55HCRTR1/HCRTR2proposed2026-04-28sda-2026-04-01-gap-v2-18cf98ca
h-debate-44c554c8661Compensatory RBP Expression Therapy0.000.55ELAVL1proposed2026-04-28sda-2026-04-01-gap-v2-68d9c9c1
h-debate-d311450401bMitochondrial RNA Processing Enhancement0.000.55LRPPRCproposed2026-04-28sda-2026-04-01-gap-v2-68d9c9c1
h-debate-c31c367bbbeRNA Modification Enzyme Modulation0.000.55METTL3proposed2026-04-28sda-2026-04-01-gap-v2-68d9c9c1
h-debate-c6005bc2428Cross-Disease RNA Granule Dissolution Therapy0.000.55G3BP1proposed2026-04-28sda-2026-04-01-gap-v2-68d9c9c1
h-debate-9531e908c33Proteostasis Network Activation for RBPs0.000.55HSPA1Aproposed2026-04-28sda-2026-04-01-gap-v2-68d9c9c1
h-debate-0425e09671fRNA Splicing Corrector Compounds0.000.55TARDBPproposed2026-04-28sda-2026-04-01-gap-v2-68d9c9c1
h-debate-b1eb50b5e4eAstrocyte Priming Therapy for Preconditioning Neuroprotection0.000.55GFAPproposed2026-04-28sda-2026-04-01-gap-v2-89432b95
h-debate-166187b528eFatty Acid Metabolism Enhancers for Activity-Dependent Neurodegeneration0.000.55CPT1Aproposed2026-04-28sda-2026-04-01-gap-v2-89432b95
h-debate-0d42b94d251LRP1-ARF1 Lactylation Inhibitors for Metabolic Neuroprotection0.000.55ARF1proposed2026-04-28sda-2026-04-01-gap-v2-89432b95
h-debate-d86d79b9d94TAK1 Pathway Modulators for Hypothalamic Metabolic Disorders0.000.55MAP3K7proposed2026-04-28sda-2026-04-01-gap-v2-89432b95
h-debate-ccbced20c91Mitochondrial Transfer Enhancers for Synaptic Dysfunction0.000.55MIRO1proposed2026-04-28sda-2026-04-01-gap-v2-89432b95
h-debate-51c4248ae68CD38 Agonist Therapy for Alzheimer's Disease0.000.55CD38proposed2026-04-28sda-2026-04-01-gap-v2-89432b95
h-debate-8c3d8c6d1a9Ginsenoside Rb1 Analogs for Complex I-Mediated Neuroprotection0.000.55NDUFS1proposed2026-04-28sda-2026-04-01-gap-v2-89432b95
h-debate-42a75b89701Epigenetic Clock Reversal Through Targeted DNA Demethylation0.000.55DNMT1proposed2026-04-28sda-2026-04-01-gap-v2-bc5f270e
h-debate-d2fa5138b6cTemporal Epigenetic Clock Synchronization Therapy0.000.55CLOCKproposed2026-04-28sda-2026-04-01-gap-v2-bc5f270e
h-debate-01c9c9962d7Protein Aggregation-Epigenetic Stress Response Modulation0.000.55PSMD1proposed2026-04-28sda-2026-04-01-gap-v2-bc5f270e
h-debate-bfe1b83aa19Inflammaging-Epigenome Decoupling Strategy0.000.55NFKB1proposed2026-04-28sda-2026-04-01-gap-v2-bc5f270e
h-debate-d028b27e4d0Mitochondrial-Nuclear Epigenetic Communication Restoration0.000.55SOD2proposed2026-04-28sda-2026-04-01-gap-v2-bc5f270e
h-debate-0b950b4ed02Epigenetic Clock Biomarker-Guided Combination Therapy0.000.55Multiple (SIRT1, MTOR, NFKB1)proposed2026-04-28sda-2026-04-01-gap-v2-bc5f270e
h-debate-334658fce29NAD+ Metabolic Rescue Via Autophagy-Epigenetic Coupling0.000.55SIRT1proposed2026-04-28sda-2026-04-01-gap-v2-bc5f270e
h-debate-99e31e7ddb3Anti-CAA Immunotherapy for Glymphatic Rescue0.000.55APP, PSEN1, C1QAproposed2026-04-28sda-2026-04-01-gap-v2-ee5a5023
h-debate-b1fcf8fa0bfArteriolosclerosis-Targeted Perivascular Space Restoration0.000.55ACTA2, COL4A1, MMP9proposed2026-04-28sda-2026-04-01-gap-v2-ee5a5023
h-debate-97553319570Perivascular Inflammation Resolution Therapy0.000.55TREM2, AQP4, C1QAproposed2026-04-28sda-2026-04-01-gap-v2-ee5a5023
h-debate-e123259d9f9Chronotherapeutic Glymphatic Enhancement0.000.55CLOCK, ARNTL, PER2, CRY1proposed2026-04-28sda-2026-04-01-gap-v2-ee5a5023
h-debate-c6e5ca34453Dual Proteinopathy Clearance via Enhanced Drainage0.000.55ACTA2, PDGFRB, PROX1proposed2026-04-28sda-2026-04-01-gap-v2-ee5a5023
h-debate-76b52c1666eCircadian Melatonin Therapy for Glymphatic Enhancement0.000.55MTNR1A, MTNR1B, CLOCK, ARNTLproposed2026-04-28sda-2026-04-01-gap-v2-ee5a5023
h-debate-1e511c421d9Sleep Architecture Optimization via Glymphatic Pacing0.000.55GABRA1, ADORA1, ADRA2Aproposed2026-04-28sda-2026-04-01-gap-v2-ee5a5023
h-debate-f74e7f8e196Akkermansia muciniphila Metabolite Inhibition0.000.55Akkermansia_Mucinaseproposed2026-04-28sda-2026-04-01-gap-20260401-225149
h-debate-eb3d3ffc951Circadian-Synchronized Microbiome Intervention0.000.55CLOCKproposed2026-04-28sda-2026-04-01-gap-20260401-225149
h-debate-7199453b125Mediterranean Diet Metabolite Synthesis via Engineered Probiotics0.000.55Custom_Metabolic_Pathwayproposed2026-04-28sda-2026-04-01-gap-20260401-225149
h-debate-2c43f3388d9Vagal Nerve Stimulation Combined with Probiotic Therapy0.000.55CHATproposed2026-04-28sda-2026-04-01-gap-20260401-225149
h-debate-46c5d88e90fEnteric Nervous System Reprogramming via Microbial Neurotransmitter Modulation0.000.55TDCproposed2026-04-28sda-2026-04-01-gap-20260401-225149
h-debate-b83436f40efInflammasome-Targeted Microbiome Modulation Therapy0.000.55NLRP3proposed2026-04-28sda-2026-04-01-gap-20260401-225149
h-debate-75f5e7789a5Prevotellaceae-Derived Butyrate Supplementation as Neuroprotective Therapy0.000.55HDAC1/HDAC2proposed2026-04-28sda-2026-04-01-gap-20260401-225149
h-debate-04ae559d2f9Metabolic Reprogramming Through TREM2 Modulation0.000.55TREM2proposed2026-04-28SDA-2026-04-06-gap-001
h-debate-3423407b441Stage-Dependent TREM2 Modulation Strategy0.000.55TREM2proposed2026-04-28SDA-2026-04-06-gap-001
h-debate-8b90a687b11Splicing-Based TREM2 Rescue Therapy0.000.55TREM2proposed2026-04-28SDA-2026-04-06-gap-001
h-debate-bad19704d4fApolipoprotein E-Mediated Senescent Cell Targeting System0.000.55APOE, LRP1, CDKN1Aproposed2026-04-28SDA-2026-04-02-gap-senescent-clearance-neuro
h-debate-7f08c3e04c9Circadian-Synchronized Senolytic Delivery0.000.55CLOCK, ARNTL, ATG5proposed2026-04-28SDA-2026-04-02-gap-senescent-clearance-neuro
h-debate-482db234f55Oligodendrocyte Precursor Cell Senescence as Primary Driver of White Matter Dege0.000.55BCL2L1, SOX10, PDGFRAproposed2026-04-28SDA-2026-04-02-gap-senescent-clearance-neuro
h-debate-0cf134d5d9bSelective Microglial Senescence Targeting via P16INK4A-Guided Senolytics0.000.55CDKN2A, BCL2L1, BCL2proposed2026-04-28SDA-2026-04-02-gap-senescent-clearance-neuro
h-debate-96d47c1edeaFisetin-Based Senomorphic Therapy for Preserving Beneficial Senescent Functions0.000.55SIRT1, FOXO3, GFAPproposed2026-04-28SDA-2026-04-02-gap-senescent-clearance-neuro
h-debate-7d54c1a9944Temporal SASP Modulation Rather Than Complete Senolytic Clearance0.000.55MTOR, RELA, NLRP3proposed2026-04-28SDA-2026-04-02-gap-senescent-clearance-neuro
h-debate-62934d147e8Senescence-Induced Tau Propagation Blockade0.000.55MAPT, CDKN2A, BCL-2 familyproposed2026-04-28SDA-2026-04-02-gap-senescent-clearance-neuro
h-var-7ca5d46fa8LAMP2A Upregulation to Enhance Chaperone-Mediated Autophagy for Tau Clearance in0.000.00LAMP2Aproposed2026-04-28SDA-2026-04-16-frontier-proteomics-1c3dba72
h-var-e44be8a8ccCell-Type-Specific TFEB Modulation Combined with Trehalose for Targeted Alzheime0.000.00TFEBproposed2026-04-28SDA-2026-04-16-frontier-proteomics-1c3dba72
h-var-346a45a59fLAMP1 Overexpression to Enhance Lysosomal Capacity Independent of TFEB in Aged S0.000.00LAMP1proposed2026-04-28SDA-2026-04-16-frontier-proteomics-1c3dba72
h-var-dd29f57963GLUT1-Mediated Carrier-Conjugate Delivery Strategy0.000.00LDLRproposed2026-04-28SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
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