| h-debate-bad19704d4f | Apolipoprotein E-Mediated Senescent Cell Targeting System | 0.00 | 0.55 | APOE, LRP1, CDKN1A | proposed | 2026-04-29 | SDA-2026-04-02-gap-senescent-clearance-neuro |
| h-debate-7f08c3e04c9 | Circadian-Synchronized Senolytic Delivery | 0.00 | 0.55 | CLOCK, ARNTL, ATG5 | proposed | 2026-04-29 | SDA-2026-04-02-gap-senescent-clearance-neuro |
| h-debate-482db234f55 | Oligodendrocyte Precursor Cell Senescence as Primary Driver of White Matter Dege | 0.00 | 0.55 | BCL2L1, SOX10, PDGFRA | proposed | 2026-04-29 | SDA-2026-04-02-gap-senescent-clearance-neuro |
| h-debate-0cf134d5d9b | Selective Microglial Senescence Targeting via P16INK4A-Guided Senolytics | 0.00 | 0.55 | CDKN2A, BCL2L1, BCL2 | proposed | 2026-04-29 | SDA-2026-04-02-gap-senescent-clearance-neuro |
| h-debate-96d47c1edea | Fisetin-Based Senomorphic Therapy for Preserving Beneficial Senescent Functions | 0.00 | 0.55 | SIRT1, FOXO3, GFAP | proposed | 2026-04-29 | SDA-2026-04-02-gap-senescent-clearance-neuro |
| h-debate-7d54c1a9944 | Temporal SASP Modulation Rather Than Complete Senolytic Clearance | 0.00 | 0.55 | MTOR, RELA, NLRP3 | proposed | 2026-04-29 | SDA-2026-04-02-gap-senescent-clearance-neuro |
| h-debate-62934d147e8 | Senescence-Induced Tau Propagation Blockade | 0.00 | 0.55 | MAPT, CDKN2A, BCL-2 family | proposed | 2026-04-29 | SDA-2026-04-02-gap-senescent-clearance-neuro |
| h-var-7ca5d46fa8 | LAMP2A Upregulation to Enhance Chaperone-Mediated Autophagy for Tau Clearance in | 0.00 | 0.00 | LAMP2A | proposed | 2026-04-28 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-var-e44be8a8cc | Cell-Type-Specific TFEB Modulation Combined with Trehalose for Targeted Alzheime | 0.00 | 0.00 | TFEB | proposed | 2026-04-28 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-var-346a45a59f | LAMP1 Overexpression to Enhance Lysosomal Capacity Independent of TFEB in Aged S | 0.00 | 0.00 | LAMP1 | proposed | 2026-04-28 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-var-dd29f57963 | GLUT1-Mediated Carrier-Conjugate Delivery Strategy | 0.00 | 0.00 | LDLR | proposed | 2026-04-28 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-var-e21591ecfd | LDLR-Primed LRP1 Transcytosis with pH-Responsive Escape Strategy | 0.00 | 0.00 | LDLR | proposed | 2026-04-28 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-var-29bac13a19 | LDLR-Mediated Neurosteroid Precursor Delivery Strategy | 0.00 | 0.00 | LDLR | proposed | 2026-04-28 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| h-var-08841db86a | Alpha-theta entrainment therapy to enhance default mode network coherence | 0.00 | 0.00 | SST | promoted | 2026-04-28 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-cedb86877e | Closed-loop transcranial focused ultrasound with gamma entrainment to restore hi | 0.00 | 0.00 | PVALB | promoted | 2026-04-28 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-bf1195d1ee | Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla | 0.00 | 0.00 | SST | promoted | 2026-04-28 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-501d347dbb | eIF2α Phosphorylation Imbalance Disrupts Mitochondrial Protein Import and Bioene | 0.00 | 0.00 | EIF2S1,eIF2α,PERK,GCN2,ATF4,TOMM20,TIMM23,NDUFS1,NDUFS3,COX4 | open | 2026-04-28 | |
| h-var-a7e2e13faf | TBK1 Loss Triggers eIF2α-Mediated Translational Repression Through Microglial SA | 0.00 | 0.00 | TBK1, EIF2S1 | debated | 2026-04-28 | SDA-2026-04-26-gap-20260425215446 |
| h-var-1f97821344 | TBK1 Loss Triggers Astrocyte-to-Neuron Senescence Propagation Through SASP-Media | 0.00 | 0.00 | TBK1 → NF-κB / IRF3 / p62-autophagy / SASP effectors | debated | 2026-04-28 | SDA-2026-04-26-gap-20260425215446 |