Oligodendrocyte Precursor Cell Senescence as Primary Driver of White Matter Degeneration

graph TD
    CDKN2A["CDKN2A"] -->|encodes| p16INK4A["p16INK4A"]
    p16INK4A_1["p16INK4A"] -->|regulates| Cellular_senescence["Cellular senescence"]
    CELLULAR_SENESCENCE["CELLULAR_SENESCENCE"] -->|causes| neuroinflammation["neuroinflammation"]
    Tau_protein["Tau protein"] -->|mediates| Tau_Propagation["Tau Propagation"]
    Tau_Propagation_2["Tau Propagation"] -->|causes| Alzheimer_disease["Alzheimer disease"]
    CELLULAR_SENESCENCE_3["CELLULAR_SENESCENCE"] -->|activates| Tau_Propagation_4["Tau Propagation"]
    senescent_neurons["senescent neurons"] -->|causes| Tau_Propagation_5["Tau Propagation"]
    senescent_microglia["senescent microglia"] -->|causes| neuroinflammation_6["neuroinflammation"]
    SASP["SASP"] -->|associated with| neuroinflammation_7["neuroinflammation"]
    MTOR["MTOR"] -->|regulates| SASP_8["SASP"]
    RELA["RELA"] -->|regulates| neuroinflammation_9["neuroinflammation"]
    p16INK4A_10["p16INK4A"] -->|biomarker for| senescent_microglia_11["senescent microglia"]
    style CDKN2A fill:#ce93d8,stroke:#333,color:#000
    style p16INK4A fill:#4fc3f7,stroke:#333,color:#000
    style p16INK4A_1 fill:#4fc3f7,stroke:#333,color:#000
    style Cellular_senescence fill:#4fc3f7,stroke:#333,color:#000
    style CELLULAR_SENESCENCE fill:#4fc3f7,stroke:#333,color:#000
    style neuroinflammation fill:#4fc3f7,stroke:#333,color:#000
    style Tau_protein fill:#4fc3f7,stroke:#333,color:#000
    style Tau_Propagation fill:#4fc3f7,stroke:#333,color:#000
    style Tau_Propagation_2 fill:#4fc3f7,stroke:#333,color:#000
    style Alzheimer_disease fill:#ef5350,stroke:#333,color:#000
    style CELLULAR_SENESCENCE_3 fill:#4fc3f7,stroke:#333,color:#000
    style Tau_Propagation_4 fill:#4fc3f7,stroke:#333,color:#000
    style senescent_neurons fill:#4fc3f7,stroke:#333,color:#000
    style Tau_Propagation_5 fill:#4fc3f7,stroke:#333,color:#000
    style senescent_microglia fill:#4fc3f7,stroke:#333,color:#000
    style neuroinflammation_6 fill:#4fc3f7,stroke:#333,color:#000
    style SASP fill:#4fc3f7,stroke:#333,color:#000
    style neuroinflammation_7 fill:#4fc3f7,stroke:#333,color:#000
    style MTOR fill:#ce93d8,stroke:#333,color:#000
    style SASP_8 fill:#4fc3f7,stroke:#333,color:#000
    style RELA fill:#ce93d8,stroke:#333,color:#000
    style neuroinflammation_9 fill:#4fc3f7,stroke:#333,color:#000
    style p16INK4A_10 fill:#4fc3f7,stroke:#333,color:#000
    style senescent_microglia_11 fill:#4fc3f7,stroke:#333,color:#000