| h-7a5be68a9e | J-protein co-chaperone repertoire enables selective recognition of pathogenic co | 0.64 | 0.58 | DNAJB6, DNAJB2, HSPA8, HSPA1A | proposed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075012-32bac138 |
| h-var-7e118a66d8 | TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration | 0.64 | 0.72 | TREM2 | archived | 2026-04-07 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-var-a8c6c6ea92 | TREM2-Mediated Mitochondrial Dysfunction in Neurodegeneration | 0.64 | 0.80 | TREM2 | promoted | 2026-04-20 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-var-56a6156e67 | TREM2-Driven Senescence Biomarker Index for Predicting Neurodegeneration Risk | 0.64 | 0.78 | TREM2 | promoted | 2026-04-20 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-f7da6372 | Mitochondrial ATP/ADP Carrier Activity as Bioenergetic Recovery Metric | 0.64 | 0.40 | SLC25A4 | proposed | 2026-04-16 | SDA-2026-04-04-gap-debate-20260403-222618-c698b06a |
| h-8b7727c1 | Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cross-Seeding | 0.64 | 0.40 | CSGA | proposed | 2026-04-02 | SDA-2026-04-01-gap-20260401-225149 |
| h-var-1dc420e7d8 | CYP46A1 Suppression for Tau-Mediated Neurodegeneration | 0.64 | 0.35 | CYP46A1 | proposed | 2026-04-07 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| h-7e846ceb | Glycine-Rich Domain Competitive Inhibition | 0.64 | 0.55 | TARDBP | debated | 2026-04-02 | sda-2026-04-01-gap-006 |
| h-metrep-b3a540aad7e | Caloric Restriction Mimetic Combination Therapy (Metformin + Resveratrol + Rapam | 0.64 | 0.75 | AMPK,PRKAA1,PRKAA2,SIRT1,MTOR,RPTOR,PPARGC1A,FOXO3,FOLH1 | proposed | 2026-04-28 | |
| h-377232dcc8 | LRRK2 G2019S Uncouples RAB29-Dependent Spatial Control from Kinase Activity (H7) | 0.64 | 0.62 | LRRK2,RAB29 | proposed | 2026-04-26 | SDA-2026-04-23-gap-debate-20260417-033119-54941818 |
| h-2901c57778 | Critical Period Hypothesis: The Therapeutic Window Closes When Neuronal Homeosta | 0.64 | 0.65 | NfL, p-tau217, p-tau231, ATF4, TOMM40 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062052-7bcf4b6c |
| h-dbfa26403a | CDK5 Inhibition at Presynaptic Terminals Prevents Activity-Dependent Tau Release | 0.64 | 0.72 | CDK5 | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-052358 |
| h-metrep-a7cf1c8bed7 | mTORC1 Displacement from Lysosomal Membrane Enables TFEB Nuclear Translocation a | 0.64 | 0.75 | MTOR,RPTOR,TFEB,RragA,RragC,GABARAPL1,LAMP1,CTSD,ULK1 | proposed | 2026-04-28 | |
| h-16ae38923d | Endosomal-Retromer Trafficking Defect as a Shared Sorting Failure | 0.64 | 0.68 | VPS35, VPS26, SORL1, SNX27 | proposed | 2026-04-28 | SDA-2026-04-28-cross-disease-synthesis |
| h-SDA-2026-04-26-gap | Circulating Endothelial Microvesicles Expressing Degraded Claudin-5 as Specific | 0.64 | 0.52 | CLDN5 fragments on CD31+/CD144+ EMVs | proposed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260426-011448-7c85f5dc |
| h-SDA-2026-04-26-gap | Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Blood as an Early Indi | 0.64 | 0.52 | MMP-9 (Matrix Metallopeptidase 9) / TIMP-1 ratio | proposed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260426-011448-7c85f5dc |
| h-3b76e515e0 | H7: mTOR Hyperactivity Blocks Autophagy, Permitting Tau Seeding | 0.64 | 0.70 | MTOR, ULK1, TFG | proposed | 2026-04-22 | SDA-2026-04-02-gap-ec-layer2-vulnerability |
| h-0c9e2166ed | Small Molecule Modulation of Phase Separation | 0.64 | 0.60 | FUS, TDP-43, G3BP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041428-53b81741 |
| h-caf71f08b9 | Colonic Th17/IL-17A Axis → Peripheral Immune Recruitment to SN and Neuronal Apop | 0.64 | 0.62 | RORC (RORγt), IL17A, IL17RA, IL17RC, CXCL9, CXCL10, CXCR3, C | proposed | 2026-04-22 | sda-2026-04-01-gap-20260401-225155 |
| h-d7e5613a0f | Mitochondrial ROS from complex I and cardiolipin instability forms a local organ | 0.64 | 0.67 | NDUFV1; NDUFV2; MT-ND genes; cardiolipin-associated ETC comp | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-181140-0af1a353-debate |
| h-1fd37610f6 | Anti-inflammatory microglial reprogramming via cystatin-C/TREM2 axis | 0.64 | 0.72 | TREM2/TYROBP | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-150544-e3a2eab9-debate |
| h-8069fba1d5 | Neuronal TET1 Upregulation Reactivates Immediate-Early Genes and Restores Dendri | 0.64 | 0.72 | TET1/5hmC | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-060512 |
| h-2e508abc40 | Iron Chelation Therapy Targeting the Labile Iron Pool | 0.64 | 0.68 | Labile iron pool (LIP) / Fenton chemistry | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-174000-6451afef-debate |
| h-dcd960ac02 | HBOT at 1.5 ATA for 60 min induces hormetic response via Nrf2 activation, enhanc | 0.64 | 0.65 | NFE2L2 (Nrf2) | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-181340-8acb24dc-debate |
| h-e67bc7eaca | Amyloid-beta induces secondary pericyte senescence after contractile and oxidati | 0.64 | 0.58 | APP/Aβ, EDN1, EDNRA, ROS | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-de5dfc4391 |
| h_seaad_002 | Heterogeneous astrocyte activation states differentially impact neuronal surviva | 0.64 | 0.78 | GFAP | promoted | 2026-04-04 | SDA-2026-04-04-analysis_sea_ad_001 |
| h-d4f71a6b | Transglutaminase-2 Cross-Linking Inhibition Strategy | 0.64 | 0.60 | TGM2 | proposed | 2026-04-02 | SDA-2026-04-01-gap-9137255b |
| h-3da804f5 | Mitochondrial NAD+ Salvage Enhancement | 0.64 | 0.50 | STING1 | proposed | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-10b5bf6f | Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention for Severe Neurodevelo | 0.64 | 0.40 | SOD1, HTT, TARDBP | proposed | 2026-04-04 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-0f2b2111 | Selective Neuronal Vulnerability Network Targeting | 0.64 | 0.65 | Cell-type specific vulnerability markers | proposed | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-trem2-3374766c | Stage-Selective TREM2 Agonism — Boosting DAM Phagocytosis in Early Amyloid Phase | 0.64 | 0.72 | TREM2 | promoted | 2026-04-04 | SDA-2026-04-02-gap-001 |
| h-da6fee1910 | H1: CK2 Hyperphosphorylation Locks G3BP1 in Hyper-condensed State | 0.64 | 0.62 | CSNK2A1/CSNK2B, G3BP1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041428-4c4414ad |
| hyp_test_c4cd97c6 | Test: TREM2 enhances amyloid clearance | 0.64 | 0.27 | TREM2 | proposed | 2026-04-17 | test-hypothesis-fixtures-v1 |
| h-d8f2bbc9 | Astrocyte Metabolic Reprogramming via APOE4 Correction | 0.64 | 0.70 | APOE | promoted | 2026-04-04 | SDA-2026-04-03-gap-seaad-v2-20260402032945 |
| h-a735b8480c | Layer-Specific Excitatory Neuron Vulnerability in Temporal Cortex | 0.64 | 0.65 | EIF2AK3 | proposed | 2026-04-28 | SDA-2026-04-28-gap-methodol-20260427-041425-9e73b245 |
| h-a2662cf8d8 | ER-Mitochondria Calcium Microdomains Couple Mitophagy and ER-Phagy Initiation | 0.64 | 0.65 | ITPR1 (IP3R1), VDAC1, MCU | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7 |
| h-dca86efa | TREM2-Dependent Microglial Phagocytosis Acts as a Strain Selection Filter | 0.64 | 0.62 | TREM2 | proposed | 2026-04-16 | SDA-2026-04-15-gap-debate-20260410-112730-24052bbe |
| h-3924cdba57 | TREM2 Agonism for Alzheimer's Disease | 0.64 | 0.70 | TREM2 | proposed | 2026-05-06 | SDA-2026-05-06-gap-test-20260425-224949 |
| h-76204e63a4 | Optogenetic PV Cell Activation Restores Gamma Power via PV Protein Upregulation | 0.64 | 0.68 | PVALB/GAD1 | proposed | 2026-04-28 | SRB-2026-04-28-h-var-e95d2d1d86 |
| h-a620b95b | CX3CL1-CX3CR1 Mimetic Therapy for Neuroprotection | 0.64 | 0.62 | CX3CL1-CX3CR1 Mimetic | proposed | 2026-04-25 | SDA-2026-04-17-gap-microglial-subtypes-pharmaco-202604170000 |
| SDA-2026-04-02-gap-t | HSP90-Tau Disaggregation Complex Enhancement | 0.63 | 0.46 | HSP90AA1 | proposed | 2026-04-16 | SDA-2026-04-04-gap-tau-prop-20260402003221 |
| h-917f37cf | DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxicity Without Directly | 0.63 | 0.55 | MAP2K7/MAP3K12 | promoted | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260410-100455-ff18091d |
| h-analogy-e866a41f | Gamma entrainment therapy to restore motor cortical inhibitory-excitatory balanc | 0.63 | 0.55 | PVALB | active | 2026-04-28 | |
| h-analogy-410d3197 | Closed-loop transcranial focused ultrasound targeting motor cortex SST interneur | 0.63 | 0.55 | SST | active | 2026-04-28 | |
| h-analogy-9377cede | TBK1 Insufficiency in Alzheimer Microglia Drives a Senescence-Like Inflammatory | 0.63 | 0.55 | TBK1 (or upstream regulator TREM2 as indirect proxy) | active | 2026-04-28 | |
| h-analogy-38e863ca | Closed-loop optogenetic targeting of PV interneurons to restore motor circuit in | 0.63 | 0.55 | | active | 2026-04-28 | |
| h-bf78d35ce1 | Thalamic Reticular Nucleus (TRN) GluN2B Hyperexcitability Disrupts AQP4 Polariza | 0.63 | 0.60 | GRIN2B (TRN neurons); AQP4 polarization via SNTA1 | proposed | 2026-04-28 | SRB-2026-04-28-h-var-e2b5a7e7db |
| h-246051ec90 | Liver-Derived Inflammatory Suppressors Downregulate Microglial IBA1 | 0.63 | 0.58 | STAT3/JAK1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041439-306c2cdb |
| h-f4e38f4d53 | G3BP1 NTF2L Domain-Mediated mRNP Scaffold Creates Core Exclusion Zone for Autoph | 0.63 | 0.52 | G3BP1 | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-041423-9c2c2ee3 |
| h-b2aeabb1 | Palmitoylethanolamide-Based Endocannabinoid Therapy | 0.63 | 0.43 | PPARA | proposed | 2026-04-16 | SDA-2026-04-16-gap-bbb-tjp-20260416041707 |