| h-97c6046c6b | H7: Aberrant RNA Template Switching Converts Granules to Aggregation Prone | 0.62 | 0.60 | G3BP1, DDX3X, DDX6 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041428-4c4414ad |
| h-SDA-2026-04-26-gap | Integrated Blood Panel of sPDGFRβ, sTM, and Circulating microRNA-320 Predicts Pr | 0.62 | 0.40 | PDGFRβ, THBD, mir320a/b/c | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-002803 |
| h-859dcabc7a | Selective p38γ MAPK Inhibition Reduces Pathological Tau Phosphorylation in Alzhe | 0.62 | 0.65 | MAPK12 | proposed | 2026-05-10 | SDA-2026-05-10-gap-test-20260425-224949 |
| h-SDA-2026-04-26-gap | Circulating Soluble PDGFRβ Reflects Pericyte Loss and Precedes Cognitive Decline | 0.62 | 0.40 | PDGFRβ | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-002803 |
| h-var-fd2fd0825b | APOE4-Targeted Ultrasonic Lipidation Enhancement for Gamma Oscillation Restorati | 0.62 | 0.41 | APOE/PVALB | proposed | 2026-04-16 | |
| h-SDA-2026-04-26-gap | RNA-Binding Protein Sequestration and 3′UTR Dysregulation | 0.62 | 0.52 | ELAVL1 (HuR), FMR1 (FMRP), TARDBP (TDP-43); GW182 (TNRC6A) | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260412-094853-199f4f1b |
| h-SDA-2026-04-26-gap | Ribosome Stalling and Collision-Induced Translational Repression | 0.62 | 0.52 | GBA mRNA; ZNF598, GIGYF2, RQC components | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260412-094853-199f4f1b |
| h-5dbfd3aa | Heat Shock Protein 70 Disaggregase Amplification | 0.62 | 0.70 | HSPA1A | debated | 2026-04-02 | sda-2026-04-01-gap-006 |
| h-513a633f | Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics | 0.62 | 0.45 | ANXA1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-691b42f1 |
| h-5a752d3628 | Galectin-3 deletion attenuates NLRP3 inflammasome activation downstream of lysos | 0.62 | 0.70 | LGALS3 | proposed | 2026-04-22 | SDA-2026-04-04-gap-lysosomal-cathepsin-ad |
| SDA-2026-04-16-hyp-4 | Autophagy-Senescence Axis Therapeutic Window | 0.62 | 0.70 | ATG7,BCL2,BCL2L1 | promoted | 2026-04-16 | SDA-2026-04-04-gap-senescent-clearance-neuro |
| h-ebea83c410 | ATF4-DDIT3 stress signaling indirectly represses MAPT transcription during prote | 0.62 | 0.59 | ATF4 | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260411-083749-7d0cea3d-debate |
| h-dca3e907 | Serine/Arginine-Rich Protein Kinase Modulation | 0.62 | 0.40 | SRPK1 | debated | 2026-04-02 | sda-2026-04-01-gap-006 |
| h-d9604ebf | Myelin Sulfatide Restoration | 0.62 | 0.70 | GAL3ST1 | promoted | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-e5a1c16b | TFEB-PGC1α Mitochondrial-Lysosomal Decoupling | 0.62 | 0.50 | TFEB | proposed | 2026-04-02 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-a87702b6 | Cholesterol-CRISPR Convergence Therapy for Neurodegeneration | 0.62 | 0.40 | HMGCR, LDLR, APOE regulatory regions | proposed | 2026-04-02 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-var-f4b4d4de63 | Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening | 0.62 | 0.65 | PVALB | proposed | 2026-04-07 | SDA-2026-04-03-26abc5e5f9f2 |
| h-6e76ba3638 | TOM/TIM Complex Disruption Triggering Mitochondrial Integrated Stress Response ( | 0.62 | 0.55 | TOMM40, TOMM70, CLPP | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062141-739c7f1c |
| h-9a108e26 | Pharmacological Enhancement of APOE4 Glycosylation | 0.62 | 0.58 | ST6GAL1, FUT8 | debated | 2026-04-02 | sda-2026-04-01-gap-010 |
| h-1e28311b | Microglial ACE Enhancement for Amyloid Clearance | 0.62 | 0.40 | ACE | proposed | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-ee1df336 | Vagal Afferent Microbial Signal Modulation | 0.62 | 0.70 | GLP1R, BDNF | proposed | 2026-04-02 | SDA-2026-04-01-gap-20260401-225155 |
| h-40fbbb01 | SYNJ1 Aggregation and Solubility Loss Impairs PI(4,5)P2 Cycling at Synaptic Term | 0.62 | 0.62 | SYNJ1, INPP5A, PIK3CA, PLCG1 | proposed | 2026-04-16 | SDA-2026-04-16-gap-debate-20260411-065018-92a34465 |
| h-346639e8 | Designer TRAK1-KIF5 fusion proteins accelerate therapeutic mitochondrial deliver | 0.62 | 0.30 | TRAK1_KIF5A | debated | 2026-04-02 | sda-2026-04-01-gap-v2-89432b95 |
| h-6657f7cd | Sphingolipid Metabolism Reprogramming | 0.62 | 0.30 | CERS2 | debated | 2026-04-02 | sda-2026-04-01-gap-005 |
| h-aecdf76b | Microglial xCT/SLC7A11 Selective Inhibition to Reduce Non-Cell-Autonomous Glutam | 0.62 | 0.62 | SLC7A11 | proposed | 2026-04-16 | SDA-2026-04-16-gap-ferroptosis-als-d2fb6bf796ed |
| h-aefb475d5c | Tau fibrils expose neuronal phosphatidylserine and heat-shock protein 70, drivin | 0.62 | 0.65 | Phosphatidylserine, TIMD4, HSPA1A/HSPA1B, SCARF1, LRP8 | proposed | 2026-04-22 | SDA-2026-04-02-gap-synaptic-pruning-microglia |
| h-e8432692ff | Nuclear TDP-43 Depletion Drives Synaptic Splicing Dysregulation in ALS-FTD | 0.62 | 0.20 | TARDBP, splicing targets (Sortilin1, Synaptojanin1) | proposed | 2026-04-22 | SDA-2026-04-02-gap-2026-04-01-gap-006 |
| h-c5dd93610a | Locus coeruleus degeneration gates whether cholinergic dysfunction or amyloid/ta | 0.62 | 0.58 | DBH, ADRB1, ADRB2 | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-e849205bca |
| h-8af96e9ea0 | NLRP3 Inflammasome Priming Converts SCFA-Sensitive Pyroptosis into Chronic IL-1β | 0.62 | 0.70 | NLRP3, CASP1, GSDMD, IL1B, IL1R1, C3, C1QA, GPR109A (HCAR2) | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260425-225305 |
| h-019c56c1 | Cross-Cell Type Synaptic Rescue via Tripartite Synapse Restoration | 0.62 | 0.65 | SYN1, SLC1A2, and CX3CR1 | proposed | 2026-04-04 | SDA-2026-04-03-gap-seaad-v2-20260402032945 |
| h-28c25ed899 | OPC Maturation Block via PDGFRA/LXRβ | 0.62 | 0.60 | PDGFRA | proposed | 2026-04-28 | SDA-2026-04-28-gap-methodol-20260427-041425-9e73b245 |
| h-3a8f13ac | Senescence-Associated Epigenetic Phenotype (SEP) | 0.62 | 0.65 | Senescence-Associated Epigenetic Phenotype | proposed | 2026-04-25 | SDA-2026-04-19-gap-epigenetic-comparative-ad-pd-als |
| h-65a83ac920 | CX3CR1-Targeted HDAC3 Knockdown in Microglia via AAV9 Delivery | 0.62 | 0.72 | HDAC3 (class I histone deacetylase) | proposed | 2026-04-21 | SDA-2026-04-08-gap-debate-20260406-062039-47e9c8cf |
| h-b7248a5c60 | TET Enzyme-Mediated 5hmC Restoration as Neuronal Rejuvenation Strategy | 0.62 | 0.65 | TET2; TET3 | proposed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| h-a62fe64a | TREM2 Agonism to Reprogram Infiltrated Monocytes Toward Neuroprotective Phenotyp | 0.62 | 0.70 | TREM2 | promoted | 2026-04-13 | SDA-2026-04-13-gap-debate-20260411-064946-4940f331 |
| h-7094b1202c | LRRK2 Kinase Inhibition Reduces α-Synuclein Spread via Lysosomal Enhancement | 0.62 | 0.75 | LRRK2 | proposed | 2026-04-26 | test-hypothesis-fixtures-v1 |
| h-0addc33bbe | Enhanced MCU Activity Primes mPTP Opening in Motor Neurons | 0.62 | 0.60 | MCU complex (MICU1/MICU2), mitochondrial calcium regulatory | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-611cf046 |
| h-ce92f26308 | SUV39H1 Restoration Represses Aberrant Transposon Expression in Aging Neurons | 0.62 | 0.62 | SUV39H1 (KMT1A) | proposed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| h-9318aa358d | C1Q-Induced Foam Cell Formation via Scavenger Receptor Upregulation | 0.62 | 0.58 | C1QA/C1QC | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062122-b65f8ebc |
| h-f0e5efbf54 | CDK5 Inhibition Blocks Activity-Dependent Tau Propagation | 0.62 | 0.68 | CDK5 | proposed | 2026-04-28 | SDA-TEST-PREREG-003 |
| h-b4e8a2f6f9 | Selective cathepsin B inhibition prevents cathepsin leakage-mediated NLRP3 infla | 0.62 | 0.65 | CTSB | proposed | 2026-04-22 | SDA-2026-04-04-gap-lysosomal-cathepsin-ad |
| h-gwas-trem2-abi3-ph | TREM2-ABI3 actin-phagocytosis coupling is a higher-yield AD target than either l | 0.62 | 0.62 | TREM2/ABI3 | proposed | 2026-04-26 | |
| h-5faf622cdc | Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau Release from Hypers | 0.62 | 0.65 | GRIN2B | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-052358 |
| h-a5186bb8 | H7: Enteric Nervous System Alpha-Synuclein Propagation Blocker via Gut Barrier R | 0.62 | 0.72 | IL-22, REG3G, zonulin | promoted | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-093924-7330920b |
| h-a93292f54f | Metabolic Rewiring via SPP1-Induced HIF1α Glycolytic Shift | 0.62 | 0.62 | HIF1A (HIF1α), MTOR (mTORC1), EGLN1 (PHD2) | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-062118-e3613755 |
| h-a00d94b8c8 | Synaptic RNA Metabolism Dysregulation | 0.62 | 0.75 | TARDBP | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062202-5c32c50a |
| h-0bac1b92f6 | Complement C1q/C3 Blockade for Alzheimer's Disease | 0.62 | 0.65 | C1QA | proposed | 2026-05-06 | SDA-2026-05-06-gap-test-20260425-224949 |
| h-bc635955 | CSF Biomarker-Guided ABCA7 Therapeutic Dosing | 0.62 | 0.70 | ABCA7 with biomarker-guided dosing | promoted | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-180532-e8930cb8 |
| h-6b394be1 | Lysosomal pH Restoration Upstream of TFEB | 0.62 | 0.60 | ATP6V1A | proposed | 2026-04-04 | SDA-2026-04-03-gap-debate-20260403-222617-8eb5bdbc |
| h-f811f090ac | LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target | 0.62 | 0.58 | TLR4/NFKB1/NLRP3 | proposed | 2026-04-26 | SDA-2026-04-26-gut-brain-pd-ffdff6f4 |