| h_seaad_003 | Layer V excitatory neurons show selectively enhanced vulnerability through dysre | 0.63 | 0.75 | SLC17A7 | promoted | 2026-04-04 | SDA-2026-04-04-analysis_sea_ad_001 |
| h-6eb5dfe99b | Chaperone-Degradation Coupling Prevents Aggregate Persistence by Shunting Seeds | 0.63 | 0.68 | STUB1 (CHIP), UPS pathway | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062052-28cbc764 |
| h-trem2-8df94363 | TREM2 R47H Variant Correction — AAV-Mediated Rescue of Common Risk Allele | 0.63 | 0.70 | TREM2 | promoted | 2026-04-04 | SDA-2026-04-02-gap-001 |
| h-2531ed61 | Disease-Associated Microglia Metabolic Reprogramming | 0.63 | 0.70 | TREM2 | promoted | 2026-04-12 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-1ac3dd5b75 | C1Q-Triggered NLRP3 Inflammasome Assembly in Plaque Macrophages | 0.63 | 0.65 | C1QA/C1QC | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062122-b65f8ebc |
| h-fd52a7a0 | FOXO3-Longevity Pathway Epigenetic Reprogramming | 0.63 | 0.40 | FOXO3 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-bc5f270e |
| h-8d124bccfe | Enteric Nervous System Dysfunction as Self-Reinforcing Pathological Loop | 0.63 | 0.65 | SNCA/GFAP/VIP/nNOS/CHAT | proposed | 2026-04-26 | SDA-2026-04-26-gut-brain-pd-ffdff6f4 |
| h-aa33319bb9 | Autophagosome-Lysosome Fusion Defects as Primary Driver of α-Synuclein Propagati | 0.63 | 0.75 | VPS41, STX17, HOPS complex, TRPML1 (MCOLN1) | proposed | 2026-04-22 | SDA-2026-04-02-gap-2026-04-01-gap-006 |
| h-348264d348 | Pericyte senescence is sufficient to weaken the BBB even without classic amyloid | 0.63 | 0.61 | CDKN2A, CDKN1A, IL6, CXCL8, TGFB1 | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-de5dfc4391 |
| h-1e980cc6cb | Intestinal Permeability Defects → Systemic LPS Translocation → Microglial Primin | 0.63 | 0.68 | Tight junction complex (CLDN1, OCLN, TJP1), LBP, CD14, TLR4, | proposed | 2026-04-22 | sda-2026-04-01-gap-20260401-225155 |
| h-a3a1a15a56 | Butyrate-Producing Commensal Depletion Creates Vicious Cycle: HDAC3 Overactivity | 0.63 | 0.72 | HDAC3, TREM2, PGC-1α, NLRP3, HIF1α | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260425-225305 |
| h-4a83434d37 | Epigenetic Bivalency at CDKN2A Locus Distinguishes Senescent from Activated Micr | 0.63 | 0.72 | CDKN2A, H3K9me3, DREAM complex (LIN9, LIN37, RBL2) | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-6af4ba5f |
| h-0bed611702 | Nrf2 Pathway Activation Compensates for Progranulin Haploinsufficiency in FTD-GR | 0.63 | 0.60 | NFE2L2 | proposed | 2026-05-10 | SDA-2026-05-10-gap-test-20260425-224949 |
| h-9d22b570 | Programmable Neuronal Circuit Repair via Epigenetic CRISPR | 0.63 | 0.30 | NURR1, PITX3, neuronal identity transcription factors | proposed | 2026-04-02 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-c883a9eb10 | Combine Anti-AQP4 Autoimmunity Control with Astrocyte-Endfoot Repair in NMOSD | 0.63 | 0.60 | AQP4, IL6R, CD19, C5 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-7e1dc0b2 |
| h-7eea3c3380 | Treat Glymphatic Failure by Coupling AQP4-Targeted Therapy to Sleep/Noradrenergi | 0.63 | 0.58 | AQP4, ADRA2, LC | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-7e1dc0b2 |
| h-0ca883fab0 | C1q has spatially distinct functions, with synapse-bound C1q primarily nucleatin | 0.63 | 0.64 | C1QA,C1QB,C1QC,C4A,C4B,C3,ITGAM,ITGB2,LAIR1 | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-afba1a80bd |
| h-658e41c70e | CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracellular Tau Seeds, Prev | 0.63 | 0.68 | CX3CR1 | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-052358 |
| h-319955cb66 | Targeting Synaptic Vesicle Release Machinery to Block Tau Exocytosis | 0.63 | 0.65 | SNAP25 | proposed | 2026-04-22 | SDA-2026-04-04-gap-tau-prion-spreading |
| h-bbc6ede91c | PINK1/Parkin-pathway mitophagy impairment in sporadic Parkinson's disease | 0.63 | 0.64 | PINK1; PARK2; MFN2; OPTN | proposed | 2026-04-30 | SDA-2026-04-30-gap-test-20260425-224949 |
| h-815e1cb9c9 | Hierarchical Phase Separation with Scaffold Cores | 0.63 | 0.62 | Ddx6, 4E-T, FMRP, TIA1, G3BP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041428-53b81741 |
| h-ff7cdd9b05 | APOE4-microglial complement signaling causes cholinergic-enriched synaptic vulne | 0.63 | 0.67 | APOE, C1QA, C1QB, C1QC, C3, ITGAM | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-e849205bca |
| h-d44394f958 | Steric Occlusion of G3BP1 Oligomerization Interface | 0.63 | 0.68 | G3BP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041423-2d1db50c |
| h-652a706ec8 | Restoration of V-ATPase function reverses lysosomal acidification defect in AD n | 0.63 | 0.68 | ATP6V1A, ATP6V0C | proposed | 2026-04-22 | SDA-2026-04-04-gap-lysosomal-cathepsin-ad |
| h-05b40151e8 | Partial OSK Reprogramming Reverses Epigenetic Aging Without Dedifferentiation | 0.63 | 0.75 | Oct4; Sox2; Klf4; TP53 | proposed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| h-e9db71317e | ATXN2 Antisense Oligonucleotides Reduce Dipeptide Repeat Proteins in C9orf72-ALS | 0.63 | 0.55 | ATXN2 | proposed | 2026-05-10 | SDA-2026-05-10-gap-test-20260425-224949 |
| h-0d576989 | Selective Cholinergic Protection via APP Pathway Modulation | 0.63 | 0.65 | APP | proposed | 2026-04-04 | SDA-BIOMNI-CLINICAL-b7a71edd |
| SDA-2026-04-16-hyp-9 | APOE4-Driven Astrocyte Senescence as Primary Target | 0.63 | 0.46 | APOE,CDKN1A,BCL2L1 | proposed | 2026-04-16 | SDA-2026-04-04-gap-senescent-clearance-neuro |
| h-40ad6ac6 | Gut-Brain Axis M-Cell Modulation | 0.63 | 0.56 | GP2, SPIB | proposed | 2026-04-04 | SDA-2026-04-04-gap-neuroinflammation-microglial-20260404 |
| h-e23f05fb | Multi-Modal CRISPR Platform for Simultaneous Editing and Monitoring | 0.63 | 0.30 | Disease-causing mutations with integrated reporters | proposed | 2026-04-02 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-trem2-883b6abd | TREM2 Antagonism in Late-Stage Tauopathy — Reducing Neuroinflammatory Amplificat | 0.63 | 0.58 | TREM2 | proposed | 2026-04-04 | SDA-2026-04-02-gap-001 |
| h-4a31c1e0 | Quantum Coherence Disruption in Cellular Communication | 0.63 | 0.57 | TUBB3 | debated | 2026-04-02 | sda-2026-04-01-gap-009 |
| h-6f1e8d32 | Cardiovascular-Neuroinflammatory Dual Targeting | 0.63 | 0.50 | TNF/IL6 | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-1e70cd6400 | Rutin stabilizes a non-nucleating tau conformer through direct MAPT repeat-domai | 0.63 | 0.55 | MAPT | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260411-085530-9015d285-debate |
| h-065716ca | TREM2 Super-Agonist Induction of DAM Program | 0.63 | 0.22 | TREM2 | proposed | 2026-04-21 | SDA-2026-04-16-gap-20260416-220243 |
| h-a635d4e5 | Default Mode Network Circuit Stabilization | 0.63 | 0.55 | VIP | proposed | 2026-04-04 | SDA-2026-04-03-26abc5e5f9f2 |
| h-1f7e4943f9 | VEGF-family genetic control of vascular-neuronal coupling in vulnerable hippocam | 0.63 | 0.62 | VEGF | proposed | 2026-04-28 | a7f528aa-20c4-409d-a8c3-e2662850e63d |
| h-54c3df2f08 | early PD proteogenomic hubs that are both causal enough and accessible enough to | 0.63 | 0.62 | SNCA | proposed | 2026-04-28 | 8ec36980-febb-4093-a5a1-387ea5768480 |
| h-aad6475a2e | DPP6-linked neuronal regulatory networks controlling synaptic excitability and c | 0.63 | 0.62 | DPP6 | proposed | 2026-04-28 | 457c5bc3-21d8-42a3-bb99-b0fc6f3f9554 |
| h-b43242fa6b | RNA-binding protein condensate maturation from reversible phase separation to am | 0.63 | 0.62 | TDP-43 | proposed | 2026-04-28 | 0ed3c364-07fd-4620-8e90-8bd33c14e370 |
| h-bb29eefbe7 | RNA-binding protein condensate maturation from reversible phase separation to am | 0.63 | 0.62 | FUS | proposed | 2026-04-28 | 52661eaf-79f8-4647-8f48-3389f5af4d59 |
| h-f5a04f2c9c | m6A-dependent control of alpha-synuclein transcript fate and aggregation kinetic | 0.63 | 0.62 | m6A | proposed | 2026-04-28 | b7f886d9-da3f-4e0d-a8a8-9c262e268796 |
| h-f90159a23e | mutant FUS effects split between motor-neuron intrinsic stress and glial/NMJ inf | 0.63 | 0.62 | FUS | proposed | 2026-04-28 | 687fb884-6d31-47c3-a83f-074bad980db6 |
| h-8f6fd1d64f | CCL2-CCR2 myeloid signaling as a selective driver of fast-fatigable motor-neuron | 0.63 | 0.62 | CCL2-CCR2 | proposed | 2026-04-28 | f7f8019f-08f6-428b-adff-85e8ea202b60 |
| h-9192d8f97e | PD genetic aging variants accelerating cell-type-specific epigenetic clock traje | 0.63 | 0.62 | PD- | proposed | 2026-04-28 | bf5094c7-8ae0-4331-9871-d6f3078387c5 |
| h-13c4be94d5 | sex-divergent microglial activation states and X-linked immune escape genes as p | 0.63 | 0.62 | amyloid-beta | proposed | 2026-04-28 | dfb32151-9c40-452d-8063-0c57bae5c3d6 |
| h-fa69d9c90d | APOE ε4-driven microglial lipid handling as proximal driver in Non-Neuronal Tran | 0.63 | 0.62 | RNA- | proposed | 2026-04-28 | db9a224d-3ebb-429c-8f02-b703d71ca211 |
| h-efbedb10 | Peripheral-to-Central Inflammation Circuit Breaker | 0.63 | 0.61 | IL1B | proposed | 2026-04-16 | SDA-2026-04-16-gap-bbb-tjp-20260416041707 |
| h_seaad_001 | Microglial TREM2 downregulation impairs damage-associated response in late-stage | 0.63 | 0.82 | TREM2 | promoted | 2026-04-04 | SDA-2026-04-04-analysis_sea_ad_001 |
| h-var-a065d9bdf2 | TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration | 0.63 | 0.72 | TREM2 | archived | 2026-04-07 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |