| Gene Symbol | P-TAU231 |
| Appears early in AD pathogenesis | Elevations detectable before clinical symptoms |
| Correlates with tau NFT burden | Strong correlation with neurofibrillary tangle density |
| Reflects pretangle formation | May detect pretangle tau changes not visible on PET |
| Preclinical AD detection | Abnormal in cognitively normal individuals with amyloid pathology |
| Early MCI detection | More sensitive than p-tau 181 in early disease |
| Disease progression | Higher rate of change predicts faster decline |
| Research Use Only | Most p-tau 231 assays remain RUO |
| Clinical trials | Widely used as enrollment biomarker |
| Plasma version | Under development with several platforms in validation |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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