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disease 1,344 words KG: ent-dise-408ea38b 2026-03-24
kind:diseasesection:diseasesstate:published
Contents

TREM2 Variants in Alzheimer's Disease

Disease Info
PhagocytosisClears Aβ plaques, cellular debris
SurvivalPromotes microglial survival
ProliferationSupports microglial expansion
Cytokine productionRegulates inflammatory responses
Lipid metabolismProcesses lipids and lipoproteins
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (30)

TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen
Score: 0.64TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene
Score: 0.61TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener
Score: 0.61TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.59TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging
Score: 0.59

Related Analyses (30)

Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · completedNeuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archivedNeuroinflammation and microglial priming in early AD
neurodegeneration · completedTREM2 Therapeutic Strategy Post-INVOKE-2
neurodegeneration · archivedMechanistic validation of SEA-AD differential expression hyp
neurodegeneration · failed

Related Experiments (30)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.40TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40TREM2 KO amyloid pathology study
validation · completed · Score: 0.75TREM2 KO amyloid pathology study
validation · completed · Score: 0.75

See Also (15)

Vascular Dementia Mechanisms — Overlap with Alzheimer's
mechanism · Pages share 18 hypothesesUbiquitin-Proteasome System Dysfunction in Alzheimer's
mechanism · Pages share 18 hypothesesTau Kinase Signaling Cascade in Alzheimer's Disease
mechanism · Pages share 18 hypothesesTau Kinase-Phosphatase Balance in Alzheimer's Disease
mechanism · Pages share 18 hypothesesSynaptic Loss in Alzheimer's Disease Pathway
mechanism · Pages share 18 hypotheses
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