protein

ADAM10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ADAM10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

331Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	ADAM10
Full Name	A Disintegrin And Metalloproteinase Domain 10
Aliases	Kuzbanian, CD156c
Chromosome	15q21.3
Function	Alpha-secretase, cleaves APP via non-amyloidogenic pathway
Molecular Weight	84.1 kDa
Amino Acids	748
Pathways	Non-amyloidogenic APP processing, Notch signaling
UniProt ID	O14672
NCBI Gene ID	102
Ensembl ID	ENSG00000137845
OMIM	602192
GeneCards	ADAM10
Human Protein Atlas	ADAM10
Protein Length	748 amino acids
Associated Diseases	AGING, ALS, Alzheimer, Cancer, Dementia
Interactions	CD44, MTOR, AKT, BACE1, NLGN3, Rb
KG Connections	331 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ADAM10 — AlphaFold O14672 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ADAM10["ADAM10"] -->|"biomarker for"| Alzheimer_s_Disease["Alzheimer's Disease"]
    style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ADAM10["ADAM10"] -->|"regulates"| Notch_pathway["Notch pathway"]
    style Notch_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    ADAM10["ADAM10"] -->|"activates"| NLGN3["NLGN3"]
    style NLGN3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ADAM10["ADAM10"] -->|"associated"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ADAM10["ADAM10"] -->|"associated"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ADAM10["ADAM10"] -->|"therapeutic target"| Inflammation["Inflammation"]
    style Inflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ADAM10["ADAM10"] -->|"therapeutic target"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    TREM2["TREM2"] -.->|"inhibits"| ADAM10["ADAM10"]
    style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    GENES["GENES"] -->|"therapeutic target"| ADAM10["ADAM10"]
    style GENES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CAPN1["CAPN1"] -->|"therapeutic target"| ADAM10["ADAM10"]
    style CAPN1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    TTR["TTR"] -->|"therapeutic target"| ADAM10["ADAM10"]
    style TTR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    LGALS3["LGALS3"] -->|"therapeutic target"| ADAM10["ADAM10"]
    style LGALS3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style ADAM10 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (223)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Alzheimer's Disease	biomarker_for	disease	0.95
Notch pathway	regulates	pathway	0.90
DAM microglia	expressed_in	cell_type	0.75
NLGN3	activates	protein	0.70
NLGN3	regulates	protein	0.70
CYP46A1	inhibits	gene	0.70
AMYLOID	regulates	protein	0.70
APP	degrades	gene	0.65
APP	inhibits	gene	0.65
BACE1	interacts_with	gene	0.65
Alzheimer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Aging	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Liver Cancer	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Cancer	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Autoimmune	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
Ischemia	activates	disease	0.65
Ms	activates	disease	0.65
ALS	activates	disease	0.65
Dementia	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Huntington	inhibits	disease	0.65
AMYLOID PLAQUES	interacts_with	phenotype	0.65
AMYLOID PLAQUES	produces	phenotype	0.65
AGING	causes	phenotype	0.65
AMYLOID	causes	protein	0.65
AMYLOID	produces	protein	0.65
EGFR	regulates	gene	0.60

Incoming (108)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
h-trem2-fe8c644a	targets_gene	hypothesis	0.90
ALZHEIMER'S DISEASE	associated_with	disease	0.74
APP	produces	gene	0.70
TNF	inhibits	gene	0.70
TNF	regulates	gene	0.70
TNF	degrades	gene	0.70
TREM2	protects_against	gene	0.70
TEMPORAL LOBE	causes	brain_region	0.70
TEMPORAL LOBE	activates	brain_region	0.70
APP	causes	gene	0.65
AXL	interacts_with	gene	0.65
CORTEX	activates	brain_region	0.65
ERK	treats	gene	0.65
NEURONS	inhibits	cell_type	0.65
ERK	causes	gene	0.65
MITOPHAGY	regulates	phenotype	0.65
APOPTOSIS	regulates	phenotype	0.65
TREM2	inhibits	gene	0.60
CAPN1	therapeutic_target	gene	0.60
TTR	therapeutic_target	gene	0.60
LGALS3	therapeutic_target	gene	0.60
CTSD	therapeutic_target	gene	0.60
GRB2	therapeutic_target	gene	0.60
TLR4	therapeutic_target	gene	0.60
NFE2L2	therapeutic_target	gene	0.60
RPS6KA1	therapeutic_target	gene	0.60
HIF1A	therapeutic_target	gene	0.60
GRIN1	therapeutic_target	gene	0.60
PLCB4	activates	gene	0.60
APLP2	activates	gene	0.60
APLP1	activates	gene	0.60
AKT	activates	gene	0.60
APP	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
HSP70	inhibits	gene	0.60
TAU	inhibits	gene	0.60
GFAP	activates	gene	0.60
NLGN3	inhibits	gene	0.60
SORL1	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
GRN	associated_with	gene	0.60
MTOR	activates	gene	0.60
GBA	associated_with	gene	0.60
DDX1	associated_with	gene	0.60
SYP	regulates	gene	0.60
BDNF	activates	gene	0.60
TRKB	inhibits	gene	0.60
ABCA7	biomarker_for	gene	0.60
SIRT1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ADAM10

Understanding Entity Pages

Wiki Pages (21)

ADAM10 — A Disintegrin And Metalloproteinase Domain 10

Epigenetic Alterations in Alzheimer's Disease

RNA Metabolism Dysregulation in Alzheimer's Disease

Beta-Secretase (BACE1) Protein

Genistein for Mild Cognitive Impairment (NCT07385937)

Amyloid-Beta Aggregation and Plaque Formation

Notch Signaling Pathway in Neurodegeneration

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

Amyloid Precursor Protein (APP)

TREM2 Signaling in Neurodegeneration

Gamma-Secretase Complex (γ-Secretase)

AP2M1 Gene

APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chain

NICASTRIN Gene

Neprilysin (NEP / CD10 / MME)

Amyloid-Beta (Aβ)

Neuritic Plaques

ADAM15 Protein

APP Protein

amyloid-cascade-hypothesis

Neuropeptide Y Signaling in Neurodegeneration