biomarker 1,534 words KG: PARKINSONS
Contents

tonsillar-alpha-synuclein-parkinsons

🔬 Protein Info
Gene Symbolparkinsons
Aliasesparkinsons
AccessibilityLocated in the oropharynx, tonsils are readily accessible for biopsy under local anesthesia
Lymphoid architectureThe follicular structure provides abundant immune cells that may sequester pathological proteins
InnervationRich autonomic innervation allows for potential early detection of nerve-related pathology
Minimal invasivenessCompared to gastrointestinal biopsies or cerebrospinal fluid collection
Stages 1-2Pathology limited to peripheral and lower brainstem regions
Stages 3-4Midbrain involvement (substantia nigra) with motor manifestations
Stages 5-6Neocortical spread with advanced cognitive decline
Associated DiseasesPARKINSON, disease
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph