| Gene Symbol | ent-gene-8cd44c77 |
| Morphology | agouti-related protein expressing neuron (source: Cell Ontology) |
| SCN neuron loss | Reduced vasopressin and VIP-expressing neurons |
| Circadian amplitude reduction | Weakened daily rhythms of cortisol, melatonin |
| Sleep fragmentation | Increased night-time awakenings, reduced slow-wave sleep |
| sundowning | Exacerbation of confusion in evening hours |
| AgRP/NPY neurons | Dysregulated in early AD, contributing to appetite changes |
| POMC neurons | Reduced in AD brains, affecting satiety signaling |
| Leptin resistance | Common in AD, linked to hypothalamic inflammation |
| Insulin resistance | Hypothalamic insulin signaling impaired in AD |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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