clinical 2,504 words KG: ent-gene-47202345 2026-03-28
kind:clinical-trialsection:clinical-trialsstate:publishedphase:phase-1-2intervention:adaptive-dbs
Contents

ARC-IM Adaptive Neurostimulation for Parkinson's Disease

🔬 Protein Info
Gene SymbolARC
Full NameIM Adaptive Neurostimulation for Parkinson's Disease
Chromosome8q24.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressioncortex and hippocampus with synaptic localization
PathwaysAkt, Complement, Endocytosis, Exocytosis, Long-Term Potentiation
UniProt IDQ7Z594
NCBI Gene ID23237
Ensembl IDENSG00000132740
OMIM602473
GeneCardsARC
Human Protein AtlasARC
Trial IDNCT06295614
SponsorEPFL / Neuroloop Collaboration
PhasePhase 1/2
Associated DiseasesALS, Alzheimer, Glaucoma, Macular Degeneration, Retinopathy
InteractionsNTS, NESTIN, PIK3R3, PI3K, PTEN, IL6
KG Connections248 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (29)

SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
PARP1 Inhibition Therapy
Score: 0.58
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51

Related Analyses (30)

TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · archived
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed

Related Experiments (30)

AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-47202345 data_in benchmark_ot_ad_answer_key:ARC
benchmark_ot_ad_answer_key:ARC data_in ent-gene-47202345