gene 736 words KG: CDKL5
kind:genesection:entitiesstate:publishedtopic:neurodevelopmental-epilepsy
Contents

CDKL5

🧬 Gene Info
Gene SymbolCDKL5
Full NameCyclin-Dependent Kinase-Like 5
ChromosomeXp22.13
Protein FamilyCDK family (CDK1-18), MAPK/CDK group
Protein TypeKinase
Functionencodes a serine-threonine kinase expressed predominantly in the developing brain, particularly in neurons.
Primary ExpressionBrain (neurons, high in cortex, hippocampus, cerebellum); low elsewhere
Molecular Weight145 kDa
Amino Acids075 aa
PathwaysMAPK
UniProt IDQ6VAC4
NCBI Gene ID6792
Ensembl IDENSG00000008086
OMIM300203
GeneCardsCDKL5
Human Protein AtlasCDKL5
Associated Diseasesneurodegeneration
InteractionsERK, APOPTOSIS
KG Connections16 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (1)

HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.44

Related Analyses (13)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Mitochondrial transfer between neurons and glia
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (5)

Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation
validation · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (6)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Genes
index · KG edge: contributes_to
Neurogenesis
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates

Knowledge Graph (12 edges)

CDKL5 associated_with HCN1
CDKL5 associated_with KCNQ2
CDKL5 associated_with PLCB1
CDKL5 associated_with SCN1A
CDKL5 associated_with SCN2A
CDKL5 associated_with SCN8A
CDKL5 associated_with STXBP1
CDKL5 associated_with WWOX
CDKL5 activates ERK
CDKL5 activates Als