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gap 1,503 words KG: DEMENTIA 2026-03-29
kind:gap-analysissection:gapsstate:published
Contents

Frontotemporal Dementia Knowledge Gaps

Knowledge Graph

Related Hypotheses (3)

Glymphatic-Mediated Tau Clearance Dysfunction
Score: 0.55Dual-Circuit Tau Vulnerability Cascade
Score: 0.50Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio
Score: 0.49

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedHow do pathological stress granules in neurodegeneration esc
neurodegeneration · failedRNA binding protein dysregulation across ALS FTD AD
neurodegeneration · failedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed

Related Experiments (5)

Tau depletion effects on neuronal development in primary cul
exploratory · proposed · Score: 0.90Microtubule domain analysis in adult axons
exploratory · proposed · Score: 0.80FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation
clinical · proposed · Score: 0.40Pre-Symptomatic Tau Detection in MAPT Mutation Carriers
clinical · proposed · Score: 0.40TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism an
validation · proposed · Score: 0.40

Knowledge Graph (12 edges)

DEMENTIA interacts_with FRONTOTEMPORAL
DEMENTIA interacts_with FTD
DEMENTIA interacts_with P62
DEMENTIA interacts_with SQSTM1
DEMENTIA interacts_with STING
DEMENTIA activates ULK1
DEMENTIA degrades ENDOTHELIAL
DEMENTIA causes HIF1A
DEMENTIA activates JNK
DEMENTIA activates NLRP3
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