concept

FRONTOTEMPORAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FRONTOTEMPORAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

526Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

FRONTOTEMPORAL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, interacts with. Associated with ALS, ALZHEIMER, ALZHEIMER'S DISEASE. Connected to 113 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	FRONTOTEMPORAL
Key Genes/Proteins	C9ORF72
Related Diseases	FTD, NEURODEGENERATION, ALZHEIMER'S, ALZHEIMER'S DISEASE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FRONTOTEMPORAL["<b>FRONTOTEMPORAL</b>"]
    FRONTOTEMPORAL -->|"interacts"| FTD["FTD"]
    FRONTOTEMPORAL -->|"interacts"| FUS["FUS"]
    FRONTOTEMPORAL -->|"interacts"| LC3["LC3"]
    FRONTOTEMPORAL -->|"interacts"| OPTN["OPTN"]
    FRONTOTEMPORAL -->|"interacts"| P62["P62"]
    FRONTOTEMPORAL -->|"interacts"| SQSTM1["SQSTM1"]
    FRONTOTEMPORAL -->|"interacts"| STING["STING"]
    FRONTOTEMPORAL -->|"interacts"| UBIQUITIN["UBIQUITIN"]
    FRONTOTEMPORAL -->|"activates"| ULK1["ULK1"]
    FRONTOTEMPORAL -->|"causes"| HIF1A["HIF1A"]
    FRONTOTEMPORAL -->|"activates"| JNK["JNK"]
    FRONTOTEMPORAL -->|"activates"| MAPK["MAPK"]
    ALS["ALS"] -->|"interacts"| FRONTOTEMPORAL
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"interacts"| FRONTOTEMPORAL
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| FRONTOTEMPORAL
    BECN1["BECN1"] -->|"interacts"| FRONTOTEMPORAL
    C9ORF72["C9ORF72"] -->|"interacts"| FRONTOTEMPORAL
    DEMENTIA["DEMENTIA"] -->|"interacts"| FRONTOTEMPORAL
    ALZHEIMER["ALZHEIMER"] -->|"activates"| FRONTOTEMPORAL
    AMPK["AMPK"] -->|"activates"| FRONTOTEMPORAL
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| FRONTOTEMPORAL
    BCL2["BCL2"] -->|"regulates"| FRONTOTEMPORAL

Outgoing (129)

Target	Relation	Type	Str
FTD	accumulates_in	disease	0.65
MOTOR NEURON	activates	cell_type	0.65
NEURON	activates	cell_type	0.65
NEURONS	activates	cell_type	0.65
NEURODEGENERATION	causes	disease	0.65
FTD	expressed_in	disease	0.65
NEURODEGENERATION	contributes_to	disease	0.65
MICROGLIA	contributes_to	cell_type	0.65
NEURON	contributes_to	cell_type	0.65
NEURON	accumulates_in	cell_type	0.65
NEURONS	accumulates_in	cell_type	0.65
FTD	interacts_with	disease	0.60
FUS	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
STING	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ULK1	activates	gene	0.60
HIF1A	causes	gene	0.60
JNK	activates	gene	0.60
MAPK	activates	gene	0.60
NLRP3	activates	gene	0.60
OPTN	activates	gene	0.60
P62	activates	gene	0.60
PARKIN	activates	gene	0.60
PARKINSON	activates	disease	0.60
PINK1	activates	gene	0.60
RB1	activates	gene	0.60
RIPK3	activates	gene	0.60
SNCA	activates	gene	0.60
SQSTM1	activates	gene	0.60
STING	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
FTD	causes	disease	0.60
MTOR	interacts_with	gene	0.60
NEURON	causes	cell_type	0.60
PINK1	interacts_with	gene	0.60
TARDBP	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
VCP	activates	gene	0.60
HTT	associated_with	gene	0.60
LC3	causes	gene	0.60
MOTOR NEURON	causes	cell_type	0.60
MTOR	causes	gene	0.60
FTD	associated_with	disease	0.60
NEURON	interacts_with	cell_type	0.60
NEURONS	causes	cell_type	0.60
FTD	regulates	disease	0.60

Incoming (397)

Source	Relation	Type	Str
FRONTAL	causes	brain_region	0.65
C9ORF72	associated_with	gene	0.65
ALZHEIMER'S	activates	disease	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
ALS	expressed_in	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	disease	0.65
DEMENTIA	expressed_in	disease	0.65
ALS	biomarker_for	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	biomarker_for	disease	0.65
DEMENTIA	biomarker_for	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	contributes_to	disease	0.65
DEMENTIA	regulates	disease	0.65
ALZHEIMER	associated_with	disease	0.65
ALZHEIMER'S	associated_with	disease	0.65
ALZHEIMER'S DISEASE	associated_with	disease	0.65
ALS	interacts_with	disease	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	disease	0.60
BECN1	interacts_with	gene	0.60
C9ORF72	interacts_with	gene	0.60
DEMENTIA	interacts_with	disease	0.60
ALS	activates	disease	0.60
ALZHEIMER	activates	disease	0.60
AMPK	activates	gene	0.60
BCL2	regulates	gene	0.60
CAT	causes	gene	0.60
ENDOTHELIAL	degrades	cell_type	0.60
ALS	causes	disease	0.60
DEMENTIA	causes	disease	0.60
ALS	treats	disease	0.60
AMYOTROPHIC LATERAL SCLEROSIS	transports	disease	0.60
ATAXIA	transports	disease	0.60
ATG7	transports	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	disease	0.60
C9ORF72	causes	gene	0.60
ALS	associated_with	disease	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.60
DEMENTIA	associated_with	disease	0.60
AMYOTROPHIC LATERAL SCLEROSIS	exacerbates	disease	0.60
ATAXIA	exacerbates	disease	0.60
DEMENTIA	exacerbates	disease	0.60
ALZHEIMER	treats	disease	0.60
ALZHEIMER'S	treats	disease	0.60
ALZHEIMER'S DISEASE	treats	disease	0.60
BECN1	co_discussed	entity	0.50
C9ORF72	co_discussed	entity	0.50
DEMENTIA	co_discussed	entity	0.50
ENDOTHELIAL	co_discussed	entity	0.50
ALS	co_discussed	entity	0.50
ALZHEIMER	co_discussed	entity	0.50
ALZHEIMER'S	co_discussed	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FRONTOTEMPORAL

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

primary-progressive-aphasia

Atypical Parkinsonism

calcium-dysregulation-comparison

Corticobasal Degeneration (CBD)

Therapeutics

Neurons — Cell Type Hierarchy

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

Frontotemporal Dementia (FTD)

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub