| Gene Symbol | ULK1 |
| Chromosome | 2q24 |
| Protein Family | Ser/Thr kinase (ULK family) |
| Protein Type | Kinase |
| Target Class | Kinase |
| Function | ULK1 is the initiating kinase for autophagy |
| Mechanism of Action | Small molecule activators or inhibitors of ULK1 kinase activity to modulate autophagy |
| Subcellular Localization | Cytoplasm, autophagosome |
| Druggability | Low (0.42) |
| Clinical Stage | Phase I |
| Molecular Weight | ~1,050 amino acids (~112 kDa) |
| Amino Acids | 050 aa |
| Pathways | AUTOPHAGY, Autophagy, Cell Cycle, Chaperone, Differentiation |
| UniProt ID | Q8N448 |
| GeneCards | ULK1 |
| Human Protein Atlas | ULK1 |
| Associated Diseases | AD, ALI, ALS, ALZHEIMER, AMI, ARM |
| Known Drugs/Compounds | RAPAMYCIN, Shikonin, echinacoside, statins, ALT001, rapamycin |
| Interactions | CLOCK, ATG5, EIF4EBP1, LC3, MTOR, ABCG1 |
| SciDEX Target | View Target Profile (1 clinical trials) |
| SciDEX Hypotheses | TFEB-Independent Autophagy Bypass |
| KG Connections | 2349 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |