| Gene Symbol | P62 |
| Full Name | p62 - Sequestosome 1 (SQSTM1) |
| Protein Type | Protein |
| Function | Cargo Recognition: UBA domain binds polyubiquitinated proteins |
| Molecular Weight | 62 kDa |
| Pathways | AUTOPHAGY, Adaptive Immunity, Akt, Angiogenesis, Apoptosis |
| UniProt ID | Q13501 |
| GeneCards | P62 |
| Human Protein Atlas | P62 |
| PB1 Domain (N-terminal, 1-122) | Mediates self-oligomerization through front-to-back interactions. Enables p62 to form helical filaments and phase-separated condensates that concentrate cargo for autophagy. |
| ZZ Zinc Finger Domain (122-195) | Binds to NEMO and RIPK1, linking p62 to NF-κB signaling. |
| TB Domain (195-255) | Involved in TRAF6 binding and NF-κB activation. |
| KEAP1-Interacting Region (KIR, 347-356) | Binds to KEAP1, competing with NRF2 and activating antioxidant responses. |
| UBA Domain (C-terminal, 386-440) | Ubiquitin-associated domain that binds polyubiquitin chains (preferentially K63-linked and K48-linked) on cargo proteins.[@lamark2013] |
| Associated Diseases | Aging, als, Alzheimer, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | rapamycin, RAPAMYCIN |
| Interactions | 6-OHDA, ABCA1, ABCD3, ABCG1, ACHE, ACOD1 |
| KG Connections | 2889 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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