protein 1,100 words KG: P62 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

p62 - Sequestosome 1 (SQSTM1)

🔬 Protein Info
Gene SymbolP62
Full Namep62 - Sequestosome 1 (SQSTM1)
Protein TypeProtein
FunctionCargo Recognition: UBA domain binds polyubiquitinated proteins
Molecular Weight62 kDa
PathwaysAUTOPHAGY, Adaptive Immunity, Akt, Angiogenesis, Apoptosis
UniProt IDQ13501
GeneCardsP62
Human Protein AtlasP62
Associated DiseasesALS, ALZHEIMER'S DISEASE, Aging, Alzheimer, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsRAPAMYCIN, rapamycin
InteractionsACTB, APOA1, ULK1, ABCA1, ABCG1, APOE
KG Connections2889 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (8)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived

Related Experiments (2)

iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85

See Also (6)

ADRB2 Gene
gene · KG edge: therapeutic_target
ADAM8 Gene
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates
ABCG1 Gene
gene · KG edge: interacts_with
ABCD3 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

P62 associated_with APOE
P62 associated_with PTEN
P62 associated_with JUN
P62 associated_with NRF2
P62 co_discussed SQSTM1
P62 co_discussed ULK1
P62 co_discussed PINK1
P62 co_discussed RIPK3
P62 co_discussed TFEB
P62 co_discussed SOD1