concept

ENDOTHELIAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOTHELIAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1631Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ENDOTHELIAL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, causes. Associated with ALS, ALZHEIMER, ATHEROSCLEROSIS. Connected to 168 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ENDOTHELIAL
Key Genes/Proteins	STAT3, P53, STING, GPX4, TNF, ROS
Related Diseases	FRONTOTEMPORAL DEMENTIA
Linked Hypotheses	2 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Corticobasal Syndrome (CBS)

disease · 11374 words

→

Pathway Diagram

graph TD
    ENDOTHELIAL["<b>ENDOTHELIAL</b>"]
    ENDOTHELIAL -->|"causes"| INFLAMMATION["INFLAMMATION"]
    ENDOTHELIAL -->|"contributes to"| IMMUNE_RESPONSE["IMMUNE RESPONSE"]
    ENDOTHELIAL -->|"degrades"| FRONTOTEMPORAL["FRONTOTEMPORAL"]
    ENDOTHELIAL -->|"degrades"| FTD["FTD"]
    ENDOTHELIAL -->|"degrades"| GBA["GBA"]
    ENDOTHELIAL -->|"causes"| HIF1A["HIF1A"]
    ENDOTHELIAL -->|"activates"| JNK["JNK"]
    ENDOTHELIAL -->|"interacts"| LC3["LC3"]
    ENDOTHELIAL -->|"activates"| MAPK["MAPK"]
    ENDOTHELIAL -->|"activates"| NLRP3["NLRP3"]
    ENDOTHELIAL -->|"activates"| OPTN["OPTN"]
    ENDOTHELIAL -->|"activates"| P62["P62"]
    CD2AP["CD2AP"] -->|"causes"| ENDOTHELIAL
    ALS["ALS"] -->|"activates"| ENDOTHELIAL
    ALZHEIMER["ALZHEIMER"] -->|"activates"| ENDOTHELIAL
    AMPK["AMPK"] -->|"activates"| ENDOTHELIAL
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| ENDOTHELIAL
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ENDOTHELIAL
    BCL2["BCL2"] -->|"regulates"| ENDOTHELIAL
    BECN1["BECN1"] -->|"interacts"| ENDOTHELIAL
    CAT["CAT"] -->|"causes"| ENDOTHELIAL
    DEMENTIA["DEMENTIA"] -->|"degrades"| ENDOTHELIAL

Outgoing (277)

Target	Relation	Type	Str
T CELL	contributes_to	cell_type	0.65
NEUTROPHIL	increases	cell_type	0.65
STAT3	activates	gene	0.65
NEURON	expressed_in	cell_type	0.65
P53	interacts_with	gene	0.65
HIPPOCAMPUS	inhibits	brain_region	0.65
STING	increases	gene	0.65
P53	activates	gene	0.65
GPX4	interacts_with	gene	0.65
TNF	activates	gene	0.65
FRONTOTEMPORAL DEMENTIA	degrades	disease	0.65
ROS	activates	gene	0.65
STING	promotes	gene	0.65
METFORMIN	causes	drug	0.65
RAPAMYCIN	interacts_with	drug	0.65
GPX4	ubiquitinates	gene	0.65
UBIQUITIN	ubiquitinates	gene	0.65
ROS	causes	gene	0.65
ROS	promotes	gene	0.65
MICROGLIA	inhibits	cell_type	0.65
RESVERATROL	targets	drug	0.65
NAD	regulates	gene	0.65
NEURODEGENERATION	phosphorylates	disease	0.65
TAU	phosphorylates	gene	0.65
MICROGLIA	activates	cell_type	0.65
NOTCH	regulates	gene	0.65
FRONTOTEMPORAL	degrades	disease	0.60
FTD	degrades	disease	0.60
GBA	degrades	gene	0.60
HIF1A	causes	gene	0.60
JNK	activates	gene	0.60
LC3	interacts_with	gene	0.60
MAPK	activates	gene	0.60
NLRP3	activates	gene	0.60
OPTN	activates	gene	0.60
P62	activates	gene	0.60
PARKIN	activates	gene	0.60
PARKINSON	activates	disease	0.60
PINK1	activates	gene	0.60
RAS	degrades	gene	0.60
RB1	activates	gene	0.60
RIPK3	activates	gene	0.60
SNCA	activates	gene	0.60
SQSTM1	activates	gene	0.60
STING	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
STROKE	associated_with	disease	0.60
OCLN	causes	gene	0.60
PERICYTE	contributes_to	cell_type	0.60
PERICYTES	contributes_to	cell_type	0.60

Incoming (1354)

Source	Relation	Type	Str
ATHEROSCLEROSIS	causes	disease	0.65
CANCER	regulates	disease	0.65
ASTROCYTE	expressed_in	cell_type	0.65
ASTROCYTES	expressed_in	cell_type	0.65
ALZHEIMER	contributes_to	disease	0.65
ALZHEIMER'S	contributes_to	disease	0.65
ALZHEIMER'S DISEASE	contributes_to	disease	0.65
ATHEROSCLEROSIS	processes	disease	0.65
CD2AP	causes	gene	0.60
CD2AP	inhibits	gene	0.60
CD2AP	regulates	gene	0.60
ALS	activates	disease	0.60
ALZHEIMER	activates	disease	0.60
AMPK	activates	gene	0.60
BCL2	regulates	gene	0.60
BECN1	interacts_with	gene	0.60
CAT	causes	gene	0.60
DEMENTIA	degrades	disease	0.60
CLDN5	regulates	gene	0.60
AKT	activates	gene	0.60
CANCER	promotes	disease	0.60
DENDRITIC CELL	interacts_with	cell_type	0.60
ATG7	causes	gene	0.60
AKT	interacts_with	gene	0.60
BAX	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60
BECN1	activates	gene	0.60
CREB	activates	gene	0.60
ATHEROSCLEROSIS	contributes_to	disease	0.60
DIABETES	contributes_to	disease	0.60
AKT	causes	gene	0.60
AKT	targets	gene	0.60
ASTROCYTE	inhibits	cell_type	0.60
CHAT	interacts_with	gene	0.60
CHAT	causes	gene	0.60
APP	regulates	gene	0.60
BACE1	regulates	gene	0.60
ASTROCYTE	treats	cell_type	0.60
ASTROCYTES	treats	cell_type	0.60
ASTROCYTE	promotes	cell_type	0.60
ASTROCYTES	promotes	cell_type	0.60
CXCL10	promotes	gene	0.60
CD2AP	co_discussed	entity	0.50
ANGIOGENESIS	co_discussed	entity	0.50
AXON	co_discussed	entity	0.50
AUTOPHAGY	co_discussed	entity	0.50
BECN1	co_discussed	entity	0.50
DEMENTIA	co_discussed	entity	0.50
BBB	co_discussed	entity	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Synthetic Biology BBB Endothelial Cell Reprogramming	0.565	neurodegeneration	Blood-brain barrier transport mechanisms
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat	0.505	neurodegeneration	Perivascular spaces and glymphatic clear

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244]	Fei Y, Huang X, Ning F, Qian T, Cui J, W	Biomed Pharmacother	2024	1
Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induce [PMID:34217286]	Wang XY, Li XY, Wu CH, Hao Y, Fu PH, Mei	Respir Res	2021	1
The glycocalyx: a novel diagnostic and therapeutic target in sepsis. [PMID:30654825]	Uchimido R, Schmidt EP, Shapiro NI	Crit Care	2019	1
Pathogenic Significance of Serum Syndecan-1 and Syndecan-4 in Psoriasis. [PMID:41839009]	Yıldırım MA, Korkmaz S, Çelik HHA, Büyük	Cutis	2026	0
CD138 expression in the endometrium associates with endometrial timing and infla [PMID:41858134]	Odendaal J, Fishwick K, Correia GDS, Lee	Human reproduction (Oxford, En	2026	0
[Multicenter prospective study on the diagnostic value of syndecan-1 for necroti [PMID:41914411]	Yin XY, Zhao ZH, Wang Y, Cai N, Chen S	Zhongguo dang dai er ke za zhi	2026	0
Association of Viraemic Phase Viral Load, Antibody Responses, and Immune Biomark [PMID:41891425]	Alagarasu K, Gurav YK, Pulinchani A, Bac	Journal of medical virology	2026	0
Effect of Normothermic Machine Perfusion on Glycocalyx Shedding During Liver Tra [PMID:41847595]	Mathis S, Putzer G, Gasteiger L, Staier	Transplant international : off	2026	0
Cathepsin S is a novel target for age-related dry eye. [PMID:34910926]	["Yu Z", "Li J", "Govindarajan G", "Hamm	Experimental eye research	2022	0
Ageing alters the lipid sensing process in the hypothalamus of Wistar rats. Effe [PMID:33544062]	["Rodr\u00edguez M", "Pintado C", "Torri	Nutritional neuroscience	2022	0
Intrinsic functional neuron-type selectivity of transcranial focused ultrasound [PMID:33947867]	["Yu K", "Niu X", "Krook-Magnuson E", "H	Nature communications	2021	0
NK cells for cancer immunotherapy. [PMID:31907401]	["Shimasaki N", "Jain A", "Campana D"]	Nature reviews. Drug discovery	2020	0
Potent and specific MTH1 inhibitors targeting gastric cancer. [PMID:31164636]	["Zhou W", "Ma L", "Yang J", "Qiao H", "	Cell death & disease	2019	0
Clinical factors associated with worse quality-of-life scores in United States t [PMID:30898373]	["Goswami S", "Peipert B", "Mongelli M",	Surgery	2019	0
Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through [PMID:31393853]	["Parimon T", "Yao C", "Habiel D", "Ge L	JCI insight	2019	0
Arabidopsis Duodecuple Mutant of PYL ABA Receptors Reveals PYL Repression of ABA [PMID:29898403]	["Zhao Y", "Zhang Z", "Gao J", "Wang P",	Cell reports	2018	0
Cell transplantation therapy for spinal cord injury. [PMID:28440805]	["Assinck P", "Duncan G", "Hilton B", "P	Nature neuroscience	2017	0
Teacher development: a patchwork-text approach to enhancing critical reflection [PMID:24589866]	["Silva-Fletcher A", "May H", "Magnier K	Journal of veterinary medical	2014	0
Genetics and phosphoproteomics reveal a protein phosphorylation network in the a [PMID:23572148]	["Umezawa T", "Sugiyama N", "Takahashi F	Science signaling	2013	0
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. [PMID:22343897]	["Ichimura A", "Hirasawa A", "Poulain-Go	Nature	2012	0

ENDOTHELIAL

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

CBS/PSP Supplements Guide

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

neuroinflammation

CBS/PSP Treatment Rankings

Alzheimer's Disease

nct07165106

Astrocyte Reactivity Mechanism

williams-syndrome

Growth Factor Therapies

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases