gene 2,037 words KG: ent-gene-5729de9a
Contents

ABCA1 Gene

🧬 Gene Info
Gene SymbolABCAB1
Full NameATP-Binding Cassette Transporter A1
Chromosome9q31.1
Protein TypeTransporter
Functionencodes a 2,261 amino acid membrane protein that serves as the primary regulator of cellular cholesterol and phospholipid efflux to apolipoproteins.
Primary Expressionastrocytes and microglia, where it supports:
Amino Acids261 aa
UniProt IDO95477
NCBI Gene ID19
Ensembl IDENSG00000165029
OMIM205400
GeneCardsABCAB1
Human Protein AtlasABCAB1
Cholesterol effluxExports excess cellular cholesterol to lipid-poor APOE and APOA-I
Phospholipid flippaseTranslocates phosphatidylcholine and phosphatidylethanolamine
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (22)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Orexin-Microglia Modulation Therapy
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
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Related Analyses (5)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ABCA1 rs2230806 polymorphism association with dementia risk
exploratory · proposed · Score: 0.90
Metal Ion Homeostasis Dysregulation in Alzheimer's Disease
validation · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 5 hypotheses
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 4 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 4 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 4 hypotheses

Knowledge Graph (8 edges)

h-bc8867b7ad targets ent-gene-5729de9a
ent-gene-5729de9a targeted_by h-bc8867b7ad
29563219 is lipidated via ent-gene-5729de9a
29563219 lipidates ent-gene-5729de9a
37166058 upregulated in ent-gene-5729de9a
h-3f4cb83e0c targets ent-gene-5729de9a
ent-gene-5729de9a targeted_by h-3f4cb83e0c
26538644 is a key regulator of ent-gene-5729de9a

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