gene 1,736 words KG: ABHD12 2026-03-27
section:geneskind:genetopic:alzheimerstopic:parkinsons
Contents

ABHD12 Gene

🧬 Gene Info
Gene SymbolABHD12
Full NameAlpha/Beta Hydrolase Domain Containing 12
Chromosome20p11.21
Protein TypeHydrolase
Functionencodes a brain-enriched serine hydrolase enzyme that plays critical roles in lipid metabolism, endocannabinoid signaling, and neuroimmune function.
Primary Expressionthe central nervous system, particularly in neurons, microglia, and oligodendrocytes, where it hydrolyzes various lipid substrates including monoacylg
Exons14
UniProt IDQ9NWU1
NCBI Gene ID553155
Ensembl IDENSG00000153048
OMIM613599
GeneCardsABHD12
Human Protein AtlasABHD12
Gene Length27.3 kb
mRNA Length2.1 kb
Associated DiseasesFreezing Tolerance
InteractionsBRCA1
KG Connections6 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (21)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (2)

BRCA1 Gene
gene · KG edge: interacts_with
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (6 edges)

ABHD12 data_in benchmark_ot_ad_answer_key:ABHD12
ABHD12 interacts_with BRCA1
ABHD12 interacts_with HOS1
ABHD12 associated_with Freezing Tolerance
ABHD12 participates_in CBF Pathway
benchmark_ot_ad_answer_key:ABHD12 data_in ABHD12