gene 3,101 words KG: COX14 2026-03-27
kind:genesection:genestopic:mitochondriatopic:complex-ivtopic:oxidative-phosphorylationtopic:alzheimerstopic:parkinsonsstate:published
Contents

COX14 — Cytochrome C Oxidase Assembly Factor 14

🧬 Gene Info
Gene SymbolCOX14
Full NameCytochrome C Oxidase Assembly Factor 14
Protein TypeEnzyme
FunctionCOX14 functions as a specialized assembly factor that stabilizes early assembly intermediates and facilitates the incorporation of subunits into the growing complex.
Ensembl IDENSG00000178826
GeneCardsCOX14
Human Protein AtlasCOX14
Transmembrane domainAnchors the protein to the inner mitochondrial membrane
Matrix-facing domainContains functional regions for assembly factor activity
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
APOE-Dependent Autophagy Restoration
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51

Related Analyses (3)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in