gene 802 words KG: DDR2
Contents

DDR2 — Discoidin Domain Receptor 2

🧬 Gene Info
Gene SymbolDDR2
Full NameDiscoidin Domain Receptor 2
AliasesTKT, NTRKR3
Chromosome1q23.3
Protein TypeReceptor
FunctionCollagen binding induces DDR2 autophosphorylation and downstream signaling through
Primary ExpressionBrain, cartilage, bone, lung, kidney
Amino Acids896 aa
PathwaysMAPK pathway, PI3K
UniProt IDQ16832
NCBI Gene ID4921
Ensembl IDENSG00000137337
GeneCardsDDR2
Human Protein AtlasDDR2
Extracellular domainContains a DS (discoidin) domain that binds collagen
Associated DiseasesParkinson's disease
DatabasesGeneCardsHPASTRING

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Related Hypotheses (8)

APOE-Dependent Autophagy Restoration
Score: 0.85
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.82
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72

Related Analyses (7)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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