| Gene Symbol | DLST |
| Full Name | Dihydrolipoamide Succinyltransferase |
| Chromosome | 14q24.3 |
| Protein Type | Enzyme |
| Function | E1 component (OGDH): α-ketoglutarate dehydrogenase — decarboxylates α-ketoglutarate |
| Molecular Weight | 48 kDa |
| UniProt ID | [P36957](https://www.uniprot.org/uniprot/P36957) |
| Ensembl ID | ENSG00000135842 |
| GeneCards | DLST |
| Human Protein Atlas | DLST |
| Subunit structure | Forms a 24-mer core in the α-KGDH complex |
| Molecular weight | ~48 kDa per subunit |
| Catalytic function | Transfers the acyl group from the lipoyl moiety to CoA |
| Lipoate binding | Contains lipoyl-lysine domains that are essential for function |
| Associated Diseases | neurodegeneration |
| Interactions | CANCER |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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