gene 3,363 words KG: EPHA6 2026-03-25
kind:genesection:genesstate:published
Contents

EPHA6 — Ephrin Type-A Receptor 6

🧬 Gene Info
Gene SymbolEPHA6
Full NameEPH Receptor A6
Chromosome3q21.1
Protein TypeReceptor
Functionis a member of the Eph family of receptor tyrosine kinases that play critical roles in development and plasticity of the central nervous system[@kawasaki2006].
Primary ExpressionCortex, hippocampus, cerebellum, basal ganglia
Molecular Weight110 kDa
Amino Acids550 aa
Exons17
UniProt IDQ9Y232
NCBI Gene ID28534
Ensembl IDENSG00000048028
GeneCardsEPHA6
Human Protein AtlasEPHA6
Alternative NamesEphrin Type-A Receptor 6, EHK-2, EK8
Associated DiseasesAlzheimer's Disease, Parkinson's Disease
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
TREM2-Dependent Microglial Senescence Transition
Score: 0.69

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 4 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses