gene 554 words KG: LRP3
Contents

LRP3 — Low Density Lipoprotein Receptor-Related Protein 3

🧬 Gene Info
Gene SymbolLRP3
Full NameLow Density Lipoprotein Receptor-Related Protein 3
Chromosome19q13.31
Protein FamilyLDLR receptor family
Protein TypeReceptor
FunctionLRP-family proteins typically combine extracellular ligand-binding domains with transmembrane and cytoplasmic motifs that support ligand uptake, trafficking, and downstream signaling.[@herz2001] Withi
Primary ExpressionBrain (cortex, hippocampus), heart, skeletal muscle
Molecular Weight250 kDa
Amino Acids325 aa
UniProt IDO75074
NCBI Gene ID4037
Ensembl IDENSG00000186603
GeneCardsLRP3
Human Protein AtlasLRP3
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (45)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
SASP-Mediated Complement Cascade Amplification
Score: 0.82
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.80
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
pg 1/3Next →

Related Analyses (22)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 4 hypotheses
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 4 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.