gene 554 words KG: LRP3
Contents

LRP3 — Low Density Lipoprotein Receptor-Related Protein 3

🧬 Gene Info
Gene SymbolLRP3
Full NameLow Density Lipoprotein Receptor-Related Protein 3
Chromosome19q13.31
Protein FamilyLDLR receptor family
Protein TypeReceptor
FunctionLRP-family proteins typically combine extracellular ligand-binding domains with transmembrane and cytoplasmic motifs that support ligand uptake, trafficking, and downstream signaling.[@herz2001] Withi
Primary ExpressionBrain (cortex, hippocampus), heart, skeletal muscle
Molecular Weight250 kDa
Amino Acids325 aa
UniProt IDO75074
NCBI Gene ID4037
Ensembl IDENSG00000186603
GeneCardsLRP3
Human Protein AtlasLRP3
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (45)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Purinergic Signaling Polarization Control
Score: 0.71
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Membrane Cholesterol Gradient Modulators
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Microbial Inflammasome Priming Prevention
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
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Related Analyses (22)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 4 hypotheses
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 4 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

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