| Gene Symbol | PPP1R1B |
| Full Name | Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B |
| Chromosome | 17q21.31 |
| Protein Type | Phosphatase |
| Function | DARPP-32 is a bifunctional signaling protein that acts as both a protein phosphatase 1 (PP1) inhibitor and a protein kinase A (PKA) substrate. |
| Primary Expression | the striatum (caudate nucleus and putamen), with highest levels in medium spiny neurons |
| Subcellular Localization | nucleus accumbens, olfactory tubercle, and cerebral cortex |
| Molecular Weight | 32 kDa |
| Pathways | Synaptic Plasticity |
| UniProt ID | Q9UDW6 |
| NCBI Gene ID | 5500 |
| Ensembl ID | ENSG00000131759 |
| OMIM | 168600 |
| GeneCards | PPP1R1B |
| Human Protein Atlas | PPP1R1B |
| Associated Diseases | neurodegeneration |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsHPASTRING |