pathway

Synaptic Plasticity

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Synaptic Plasticity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1707Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Synaptic Plasticity is a biological pathway involved in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 516 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Synaptic Plasticity
Key Genes/Proteins	BDNF, NEUROINFLAMMATION, OXIDATIVE STRESS, ALZHEIMER'S DISEASE, NEURODEGENERATION, ALZHEIMER
Related Diseases	Als, Neurodegeneration, Neuroinflammation, Inflammation, Alzheimer
Linked Hypotheses	6 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Synaptic_Plasticity["Synaptic Plasticity"] -->|"interacts"| Complement["Complement"]
    Synaptic_Plasticity["Synaptic Plasticity"] -->|"interacts"| Nf__b["Nf-Kappab"]
    MAP2["MAP2"] -->|"contributes to"| Synaptic_Plasticity["Synaptic Plasticity"]
    MAP1B["MAP1B"] -->|"contributes to"| Synaptic_Plasticity["Synaptic Plasticity"]
    MAP6["MAP6"] -->|"associated"| Synaptic_Plasticity["Synaptic Plasticity"]
    JUN["JUN"] -->|"regulates"| Synaptic_Plasticity["Synaptic Plasticity"]
    style Synaptic_Plasticity fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (198)

Target	Relation	Type	Str
Sustained Antidepressant Effects	causes	phenotype	0.90
Cognitive Impairment	associated_with	disease	0.90
Drug-Resistant Epilepsy	associated_with	disease	0.85
Chronic Inflammatory Pain-Related Depression	involved_in	disease	0.85
Depression	involved_in	disease	0.85
Depressive Behavior	mediates	phenotype	0.85
Insomnia	associated_with	disease	0.80
Depression-Like Phenotype	protects_against	phenotype	0.80
Complement	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
SYNAPSE	activates	concept	0.50
SYNAPTIC PRUNING	activates	concept	0.50
Traumatic Brain Injury	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
disease	activates	disease	0.50
Long-Term Potentiation	activates	pathway	0.50
DOPAMINE	regulates	concept	0.50
SEROTONIN	regulates	concept	0.50
Astrocyte	activates	cell_type	0.50
Astrocyte	regulates	cell_type	0.50
disease	associated_with	disease	0.50
EXTRACELLULAR MATRIX	associated_with	concept	0.50
ALZHEIMER'S	activates	concept	0.50
Cognitive Impairment	activates	phenotype	0.50
Reactive Oxygen Species	activates	process	0.50
NEURONS	activates	concept	0.50
DOPAMINERGIC	activates	concept	0.50
GLIOSIS	activates	concept	0.50
Neuroprotection	activates	process	0.50
IGF-1	activates	concept	0.50
Neurogenesis	inhibits	pathway	0.50
DENDRITE	activates	concept	0.50
SYNCRIP	associated_with	concept	0.50
Erk Signaling	associated_with	pathway	0.50
APP/PS1	activates	concept	0.50
Neuron	activates	cell_type	0.50
CHOLESTEROL METABOLISM	activates	concept	0.50
SYNAPSE	regulates	concept	0.50
Cognitive Impairment	inhibits	phenotype	0.50
disease	regulates	disease	0.50
WNT SIGNALING	regulates	concept	0.50
disease	inhibits	disease	0.50
ALZHEIMER'S	inhibits	concept	0.50
APP/PS1	interacts_with	concept	0.50
Cortex	inhibits	brain_region	0.50
CEREBRAL CORTEX	inhibits	concept	0.50
SYNAPSE	interacts_with	concept	0.50
Neuron	interacts_with	cell_type	0.50
GLUTAMATE	interacts_with	concept	0.50

Incoming (1509)

Source	Relation	Type	Str
BDNF	activates	gene	1.00
Als	regulates	disease	1.00
Neurodegeneration	activates	disease	1.00
Als	activates	disease	1.00
Neuroinflammation	activates	disease	1.00
Inflammation	activates	disease	1.00
Alzheimer	activates	disease	1.00
Alzheimer	therapeutic_target	disease	1.00
NEUROINFLAMMATION	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
NEURODEGENERATION	activates	gene	1.00
ALZHEIMER	activates	gene	1.00
ALZHEIMER	therapeutic_target	gene	1.00
TRKB	activates	gene	1.00
Als	therapeutic_target	disease	1.00
INFLAMMATION	activates	gene	1.00
AKT	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
NEURODEGENERATION	regulates	gene	1.00
EXERCISE	activates	gene	1.00
Neurodegeneration	regulates	disease	0.95
IGF2	mediates	protein	0.95
Channelrhodopsin-2	inhibits	protein	0.95
Astrocytes	modulates	cell_type	0.95
Microglia	regulates	cell_type	0.95
Calcium Homeostasis	regulates	process	0.95
RLN	regulates	protein	0.95
Complement System	involved_in	pathway	0.95
RLN1	regulates	protein	0.95
BDNF	modulates	protein	0.95
Autophagy	involved_in	process	0.95
Cytoskeleton Disruption	associated_with	mechanism	0.95
Synaptic Pruning	regulates	process	0.90
NEUROTROPHINS	associated_with	protein	0.90
MTOR	involved_in	gene	0.90
Physical Exercise	modulates	process	0.90
Astrocytes	involved_in	cell_type	0.90
Calcium	regulates	compound	0.90
Autophagy	regulates	pathway	0.90
Ionotropic Astrocytes	suppresses	cell_type	0.90
Activated Microglia	modulates	cell_type	0.90
Berberine	protects_against	compound	0.90
BDNF	mediates	protein	0.90
BDNF/TRKB/CREB Signaling Pathway	regulates	pathway	0.90
Synaptic Serotonin Levels	regulates	biomarker	0.90
PSEN1	regulates	protein	0.90
APLP1	regulates	protein	0.90
APLP2	regulates	protein	0.90

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sleep Spindle-Synaptic Plasticity Enhancement	0.491	neurodegeneration	Sleep disruption as cause and consequenc

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Effects of caffeine on sleep and cognition. [PMID:21531247]	Snel J, Lorist MM	Prog Brain Res	2011	1
Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and [PMID:19536808]	Kunttas-Tatli E, Bose A, Kahali B, Bisho	Genesis	2009	1
CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the [PMID:41654970]	Lu W, Kawatani K, Ren Y	Alzheimers Res Ther	2026	0
Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536]	Zheng ZW, Min PX, Luo YL, Mao XF, Zhang	Neuron	2026	0
Presynaptic P/Q calcium channel deficit promotes postsynaptic excitability remod [PMID:41932329]	Thompson SJ, Miao QL, Sonig A, Noebels J	Neuron	2026	0
Estradiol modulates neuronal network hyperexcitability in select NDD risk genes. [PMID:41757108]	Pruitt A, Yang L, Lee S, Balafkan N, Sea	bioRxiv : the preprint server	2026	0
Vitamin D supplementation and COVID-19 risk: a population-based, cohort study. [PMID:34273098]	["Oristrell J", "Oliva J", "Casado E", "	Journal of endocrinological in	2022	0
Intracellular calcium homeostasis and its dysregulation underlying epileptic sei [PMID:36403388]	Zhou X, Chen Z, Xiao L, Zhong Y, Liu Y,	Seizure	2022	0
Homeostatic plasticity and burst activity are mediated by hyperpolarization-acti [PMID:33547341]	Rátkai A, Tárnok K, Aouad HE, Micska B,	Scientific reports	2021	0
Machine learning reveals bilateral distribution of somatic L1 insertions in huma [PMID:33432196]	["Zhu X", "Zhou B", "Pattni R", "Gleason	Nature neuroscience	2021	0
Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. [PMID:34381213]	["Su Z", "Zhang K", "Kappel K", "Li S",	Nature	2021	0
Prevalence and follow-up of potentially inappropriate medication and potentially [PMID:32641251]	["van Loveren F", "van Berlo-van de Laar	Journal of geriatric oncology	2021	0
Neuronal Cav3 channelopathies: recent progress and perspectives. [PMID:32638069]	Lory P, Nicole S, Monteil A	Pflugers Archiv : European jou	2020	0
Single-cell epigenomic analyses implicate candidate causal variants at inherited [PMID:33106633]	["Corces M", "Shcherbina A", "Kundu S",	Nature genetics	2020	0
Reciprocal associations between depression, anxiety and work-related injury. [PMID:31685530]	["Gerasimaviciute V", "B\u00fcltmann U",	Injury prevention : journal of	2020	0
On-surface synthesis of planar dendrimers via divergent cross-coupling reaction. [PMID:31160575]	["Li D", "Li S", "Xie Y", "Hua X", "Long	Nature communications	2019	0
STAT4 Directs a Protective Innate Lymphoid Cell Response to Gastrointestinal Inf [PMID:31562212]	["Dulson S", "Watkins E", "Crossman D",	Journal of immunology (Baltimo	2019	0
Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of ep [PMID:29728119]	["Ayg\u00f6ren-P\u00fcrs\u00fcn E", "Mag	Orphanet journal of rare disea	2018	0
Predictors of Extended Length of Hospital Stay Following Surgical Repair of Cong [PMID:30171266]	["Azhar A", "Aljefri H"]	Pediatric cardiology	2018	0
Interstitial lung abnormalities and self-reported health and functional status. [PMID:29317545]	["Axelsson G", "Putman R", "Araki T", "S	Thorax	2018	0

Synaptic Plasticity

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Atypical Parkinsonism

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

Neuroresilience Mechanisms and Evidence

Frontotemporal Dementia (FTD) Mechanistic Pathway

CBS/PSP Treatment Rankings

GRIA3 Gene

Alzheimer's Disease

nct07165106

Microglial Cells — Cell Type Hierarchy