gene 968 words KG: PPP3CA 2026-03-24
kind:genesection:genesstate:published
Contents

PPP3CA (Calcineurin Aα) — Protein Phosphatase 3 Catalytic Subunit Alpha

🧬 Gene Info
Gene SymbolPPP3CA
AliasesCalcineurin
Chromosome4p16.3
Protein TypePhosphatase
Functionis a unique calcium/calmodulin-dependent phosphatase that plays critical roles in neuronal signal transduction, synaptic plasticity, gene transcription, and immune cell activation[@klee1979].
Primary Expressiona tissue-specific manner:
Molecular Weight59 kDa
Amino Acids521 aa
Exons14
GeneCardsPPP3CA
Human Protein AtlasPPP3CA
NFAT (Nuclear Factor of Activated T-cells)Gene transcription
Synapsin IVesicle trafficking
AMPA receptor subunitsReceptor trafficking
DARPP-32Dopamine signaling
Associated DiseasesAxon Repulsion, neurodegeneration
InteractionsNLRP3
KG Connections4 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph