| Gene Symbol | CAMK2A |
| Full Name | Calcium/Calmodulin-Dependent Protein Kinase II Alpha |
| Protein Type | Serine/Threonine Kinase |
| Function | Calcium/Calmodulin-Dependent Protein Kinase II alpha (CaMKIIα) is a serine/threonine kinase that serves as a central mediator of synaptic plasticity, learning, and memory |
| Molecular Weight | 54.1 kDa (monomer) |
| Pathways | Hepatic Mitochondrial Oxidation, Intrahepatic Lipolysis, Neuronal Regeneration, Neuroregeneration, epigenetic regulation |
| UniProt ID | [Q9UQM7](https://www.uniprot.org/uniprot/Q9UQM7) |
| GeneCards | CAMK2A |
| Human Protein Atlas | CAMK2A |
| Process | Mechanism |
| [LTP](/mechanisms/long-term-potentiation) induction | CaMKII autophosphorylation at T286 |
| LTD induction | Protein phosphatases reverse CaMKII action |
| [LTP](/mechanisms/long-term-potentiation) maintenance | Persistent CaMKII activity |
| Memory consolidation | CREB activation, gene transcription |
| Approach | Agent |
| Associated Diseases | ALS, Epilepsy, Ms, Parkinson |
| Known Drugs/Compounds | Cytosolic Calcium |
| Interactions | DLG4, FOS, PARP1, SYN1, NGF, SYNPO |
| SciDEX Hypotheses | CaMKII-Dependent Synaptic Circuit Amplification |
| KG Connections | 122 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |