gene 706 words KG: SIGMA1 2026-03-24
kind:genesection:genesstate:published
Contents

SIGMA1 Gene

🧬 Gene Info
Gene SymbolSIGMA1 (SIGMAR1)
Full NameSigma Non-Opioid Intracellular Receptor 1
Chromosome9p13.3
Protein TypeChaperone
FunctionThe Sigma-1 receptor exhibits diverse biological functions
Primary ExpressionEndoplasmic reticulum, plasma membrane, mitochondria-associated membranes
Molecular Weight25 kDa
Amino Acids223 aa
Gene TypeProtein coding
UniProt IDQ99720
NCBI Gene ID10280
Ensembl IDENSG00000147955
OMIM601978
E102QMissense
L95delDeletion
Associated DiseasesNeurodegenerative Diseases, disease
KG Connections24 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (7)

Alzheimer Indonesia
institution · KG edge: biomarker_for
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: biomarker_for
Neurons
entity · KG edge: associated_with
Motor Neuron Disease
redirect · KG edge: associated_with
Neuroinflammation PET Imaging in CBS/PSP
diagnostic · KG edge: biomarker_for

Knowledge Graph (12 edges)

SIGMA1 therapeutic_target NEUROGRANIN
SIGMA1 biomarker_for NEUROGRANIN
SIGMA1 biomarker_for TREM2
SIGMA1 therapeutic_target TREM2
SIGMA1 therapeutic_target Alzheimer
SIGMA1 therapeutic_target Neuroinflammation
SIGMA1 therapeutic_target Neuron
SIGMA1 biomarker_for NEUROINFLAMMATION
SIGMA1 biomarker_for ALZHEIMER
SIGMA1 associated_with AND