gene 946 words KG: STMNT2 2026-03-16
kind:genesection:genesstate:published
Contents

STMN2 Gene

🧬 Gene Info
Gene SymbolSTMN2
Chromosome8q21.13
FunctionLike other stathmin family members, it can sequester tubulin dimers, reducing the pool of free tubulin available for microtubule polymerization.
Primary ExpressionMotor Neurons, Cortical Neurons, Sensory Neurons, Developing CNS
Molecular Weight20 kDa
PathwaysAxonal Regeneration
UniProt IDQ9BZP8
NCBI Gene ID11147
Ensembl IDENSG00000138379
GeneCardsSTMN2
Human Protein AtlasSTMN2
AttributeValue
Gene NameStathmin-2 (SCG10)
Associated DiseasesALS, NEURODEGENERATION, frontotemporal dementia
InteractionsTDP-43, SMN, Rb, UNC13A, ALS, NEURODEGENERATIVE DISEASES
SciDEX HypothesesSTMN2 Restoration as a Prerequisite for Axon Growt
KG Connections124 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Arginine Methylation Enhancement Therapy
Score: 0.46
Cryptic Exon Silencing Restoration
Score: 0.46
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 3 hypotheses